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1.
Mar Drugs ; 20(4)2022 Mar 29.
Artículo en Inglés | MEDLINE | ID: mdl-35447909

RESUMEN

Fucoxanthin (FX) is a marine carotenoid that has proven to be a promising marine drug due to the multiple bioactivities it possesses. However, the instability and poor bioavailability of FX greatly limit its application in pharmaceuticals or functional foods. In this study, the creative construction of a solid lipid nanoparticle-microcapsule delivery system using mixed lipids of palm stearin and cholesterol wrapped with gelatin/Arabic gum to load lipophilic FX was fabricated, aiming to improve the stability and bioavailability of FX. The results showed that the encapsulated efficiency (EE) and drug loading capacity (LC) of optimized FX microcapsules (FX-MCs) obtained were as high as 96.24 ± 4.60% and 0.85 ± 0.04%, respectively, after single-factor experiments. The average particle size was 1154 ± 54 nm with negative Zeta potential (-20.71 ± 0.93 mV) as depicted with size-zeta potential spectrometer. The differential scanning calorimeter (DSC) and thermogravimetric analyzer (TG) results indicated that FX-MC has a higher Tg and slower weight loss than FX monomers (FX crystal) and blank MCs. Besides, The Fourier transform infrared spectrometer (FTIR) confirmed the good double encapsulation of FX into the solid lipid and composite coacervate. Moreover, the encapsulated FX showed higher storage stability, sustained release (55.02 ± 2.80% release in 8 h), and significantly improved bioavailability (712.33%) when compared to free FX. The research results can provide a principle theoretical basis for the development and application of FX in pharmaceuticals or functional foods.


Asunto(s)
Nanopartículas , Disponibilidad Biológica , Cápsulas , Colesterol , Portadores de Fármacos/química , Liposomas , Nanopartículas/química , Tamaño de la Partícula , Xantófilas
2.
Yao Xue Xue Bao ; 48(10): 1602-10, 2013 Oct.
Artículo en Zh | MEDLINE | ID: mdl-24417089

RESUMEN

The aim of this study is to prepare self-microemulsifying drug delivery system (SMEDDS) of the mixture of paeonol (Pae) and borneol (Bor). Solubility test, ternary phase diagrams and simplex lattice method were employed to screen and optimize the formulation of the mixture of Pae and Bor-loaded SMEDDS. After formed into microemulsions, the particle diameter (PD) was determined and a TEM was employed to observe the microemulsions' morphology. The contents of Pae and Bor were determined by gas chromatography. As a result, while ethyl oleate (EO) as the oil phase, cremophor EL35 (EL35) as surfactant and Transcutol HP (HP) as cosurfactant, the range of the microemulsion on the ternary phase diagram was larger than other combinations. And at a ratio of 20:45:35, the microemulsions' PD was about 34 nm and the polydispersity index (PI) was about 0.2. There were 16% of Pae, 2% of Bor, 16% of EO, 37% of EL35 and 29% of HP in the prepared SMEDDS. The preparation process of the Pae and Bor-loaded SMEDDS based on Xingbi Fang is simple and feasible. This study provides a reference for the researches on the related traditional Chinese medicine and the related components.


Asunto(s)
Acetofenonas/administración & dosificación , Canfanos/administración & dosificación , Sistemas de Liberación de Medicamentos/métodos , Medicamentos Herbarios Chinos/administración & dosificación , Acetofenonas/toxicidad , Administración Intranasal , Animales , Bufonidae , Canfanos/toxicidad , Cilios/efectos de los fármacos , Combinación de Medicamentos , Medicamentos Herbarios Chinos/toxicidad , Emulsiones , Glicoles de Etileno/química , Femenino , Masculino , Mucosa Nasal/efectos de los fármacos , Ácidos Oléicos/química , Tamaño de la Partícula , Polietilenglicoles/química , Solubilidad , Tensoactivos/química
3.
Angiology ; 61(5): 427-36, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20395233

RESUMEN

To assess the effect of intensive statins therapy on the outcome of small-diameter vascular prosthesis, we investigated whether atorvastatin treatment (30 mg/d) could accelerate the re-endothelialization process and improve the patency rate in a canine infrarenal abdominal aorta-expanded polytetrafluoroethylene (ePTFE) bypass model. Furthermore, we also evaluated the effect of atorvastatin on the migratory and adherent capacity of circulating endothelial progenitor cells (EPCs) in vitro. Improved patency was confirmed by Doppler sonography and arteriography. Histological and scanning electron microscopy illustrated enhanced re-endothelialization process. Treatment with atorvastatin enhanced the circulating pool of EPCs with fortified migratory and adherent capacity. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis showed that atorvastatin treatment increased endothelial nitric oxide synthase (eNOS) and kinase insert domain receptor (KDR) messenger RNA (mRNA) expression in cultured EPCs and neointima. In conclusion, intensive statin therapy could be considered a favorable option to improve small-diameter vascular graft patency.


Asunto(s)
Anticolesterolemiantes/farmacología , Prótesis Vascular , Endotelio Vascular/efectos de los fármacos , Oclusión de Injerto Vascular/patología , Ácidos Heptanoicos/farmacología , Inhibidores de Hidroximetilglutaril-CoA Reductasas/farmacología , Politetrafluoroetileno , Pirroles/farmacología , Animales , Aorta Abdominal/patología , Aorta Abdominal/cirugía , Atorvastatina , Adhesión Celular/efectos de los fármacos , Movimiento Celular/efectos de los fármacos , Perros , Células Endoteliales/efectos de los fármacos , Células Endoteliales/patología , Masculino , Microscopía Electrónica de Rastreo , Óxido Nítrico Sintasa/análisis , Cuidados Posoperatorios , Diseño de Prótesis , Ajuste de Prótesis , Células Madre/efectos de los fármacos , Células Madre/patología , Receptor 2 de Factores de Crecimiento Endotelial Vascular/efectos de los fármacos , Grado de Desobstrucción Vascular/efectos de los fármacos
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