Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review.

AIM: This article aimed to review the association of oral microbiota with digestive cancer (DC). BACKGROUND: Oral microbiota is one of the most complex ecosystems in our body. The mouth, from which the digestive system starts, may be a source of an abundant taxonomic group of microbiotas that travel to the digestive system followed by growth, reproduction, and settlement, forming a complex microecological environment causing systemic and gastrointestinal (GI) disease. REVIEW RESULTS: A total of 14 articles were chosen for review. Most studies were case-control. Both positive and negative associations were seen between oral microbiome and DC. CONCLUSION: Digestive cancer may be associated with distinctive oral microbial character. CLINICAL SIGNIFICANCE: The present systematic review enlightens the risk of digestive carcinoma with oral microbiota that may act as a biomarker for early diagnosis of DC in a more comfortable, acceptable, and noninvasive way. How to cite this article: Ikbal SKA, Yadav SK, Mehrotra R, et al. Oral Microbiota as a Diagnostic Biomarker of Digestive Cancer: A Systematic Review. J Contemp Dent Pract 2023;24(11):902-911.

Association of Serum Interleukin-10 Level with Glycemic Status to Predict Glycemic Alteration with Periodontitis: A Cross-Sectional, Observational Study.

Background and Aim: Studies showed bidirectional relationship between chronic periodontitis (CPD) and diabetes. This study was conducted to estimate the levels of serum interleukin (IL)-10 in patients with CPD and type 2 diabetes mellitus (T2DM) to evaluate the association of serum IL-10 levels with glycemic status and to evaluate the influence of periodontal inflammation on glycemic control. Setting and Design: A cross-sectional observational study. Materials and Methods: Eighty patients were divided into four groups consisting of 20 patients in each group. Group 1: healthy control, Group 2: T2DM without chronic periodontitis, Group 3: chronic periodontitis only (CPD), and Group 4: T2DM with chronic periodontitis (CPD). Plaque index, gingival index, pocket probing depth, clinical attachment loss, random blood sugar, and glycated hemoglobin (HbA1c) level were recorded for categorizing patients into aforestated groups. Serum IL-10 level was measured by ELISA kit. Statistical Analysis Used: ANOVA statistics and post hoc Tukey's test were performed for comparing individual groups. Results: IL-10 was detected lowest in Group 3 followed by Group 4. Highest level of IL-10 was found in the healthy group then in Group 2. Conclusion: IL-10 levels have an inverse relationship with HbA1c. Lowest level of IL-10 in CPD dictates periodontal inflammation itself influences in regulating serum IL-10 level and poor glycemic control. Serum IL-10 level may be one of the predictors of glycemia.