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Aim: The aim of the study was to determine the effect of different anterior reference points during facebow transfer, on sagittal inclination of occlusal plane (SIOP) and horizontal condylar guidance (HCG) values obtained on arcon and nonarcon articulators. Materials and Methods: Facebow records of 25 participants were made and transferred to Hanau Wide-Vue (WV) and Hanau H2 (H2) articulators using conventional indirect transfer (CIT), superior annular groove (SAG), and inferior annular groove (IAG) as anterior reference points. Maxillary casts were mounted on each articulator followed by mandibular mountings. Protrusive interocclusal record was used to determine HCG, and SIOP was measured as an angle between the occlusal plane of mounted maxillary cast and upper member of the articulator. Both, HCG and SIOP were measured on a digital lateral cephalogram and the values obtained were compared with previously determined values from both the articulators. Intergroup comparison was done by analysis of variance and pair-wise comparison by Tukey post hoc test. Results: Values of SIOP significantly (P = 0.00) changed on both the articulators when CIT, SAG, and IAG were the anterior reference points. The ratio of SIOP and HCG on both articulators was comparable to that of the cephalogram for CIT, IAG, but it was substantially low for SAG. Conclusions: The variation of anterior reference point changes the value of SIOP recorded on Hanau WV and H2 articulators; however, it had no effect on HCG values recorded on both the articulators. The angle between SIOP and HCG changed with variations in superior-inferior position of the mountings on both articulators.
RESUMEN
OBJECTIVES: To explore the influence of treatment package time(TPT) in high-risk oral cavity squamous cell carcinoma(OCSCC) receiving adjuvant radiotherapy with concurrent chemotherapy(CRT). MATERIALS AND METHODS: We queried our multi-institutional OCSCC collaborative database for cases diagnosed between 2005 and 2015 who underwent surgery followed by adjuvant CRT. All patients had high-risk features: extranodal extension(ENE) and/or positive surgical margin(PM). TPT was days between surgery to last radiotherapy fraction. Kaplan-Meier curves, log-rank p-values and multivariate analysis(MVA) were used to investigate the impact of TPT on overall(OS), disease-free(DFS), locoregional failure-free(LRFS) and distant metastases-free(DMFS) survival. RESULTS: We identified 187 cases: median age 58 (range, 24-87 years), males 66%, and ever smokers 69%. ENE and PM were detected in 85% and 32%, and oral tongue and floor of the mouth constituted 49% and 18%, respectively. Median radiotherapy and cisplatin doses received were 66 Gy and 200 mg/m2. Overall, median TPT was 98 (range, 63-162 days). OS was worse for TPT > 90-days (n = 134) than TPT ≤ 90 (n = 53) at two-(65% vs. 71%) and five-years (45% vs. 62%); p = 0.05, with similar results for DFS. No influence on LRFS or DMFS was noted. More lymph nodes(LN) dissected(P = 0.039), T3-4 disease(P = 0.017), and unplanned reoperations(P = 0.037) occurred with TPT > 90-days. On MVA, TPT in 10-day increments was independently detrimental for OS (Hazard Ratio: 1.14; 95 %Confidence Interval [1-1.28]; P = 0.043), perineural invasion, age and positive LN (p < 0.05 for all). CONCLUSION: In one of the largest multi-institutional cohorts, TPT > 90-days predicted worse OS for high-risk OCSCC receiving adjuvant CRT. All efforts are needed to optimize perioperative care and baseline conditions for favorable outcomes.