Effect of non-surgical periodontal therapy on patients with type 2 diabetes mellitus.

UNLABELLED: The AIM of this study was to evaluate the effect of non-surgical therapy on clinical variables and glycemic control on type 2 diabetics with chronic periodontitis. PATIENTS AND METHODS: Forty six type 2 diabetics with chronic periodontitis were randomized into two groups (group A and group B). Treatment included scaling and root planning for group A plus systematic use of doxycycline in both groups. Assessment was made prior to and 16 weeks following the therapy. RESULTS: Analysis of data showed that both groups had clinical and glycated hemoglobin (HbAlc) improvement after the treatment. Group A had a statistically significant reduction of plaque index and bleeding on probing scores compared with controls (P < 0.05) at 16 weeks. CONCLUSION: These results suggest that non-surgical therapy is of value in maintaining periodontal health and may be beneficial in reducing blood glucose level in type 2 diabetics with chronic periodontitis.

Effects of surgical periodontal therapy on serum levels of TNF-alpha in patients with chronic periodontitis.

AIM: To find if serum levels of tumor necrosis factor-alpha (TNF-alpha) can change after a surgical periodontal treatment. PATIENTS AND METHODS: Moderate to severe periodontitis subjects who received basic periodontal treatment were included in the study and randomly divided into two groups. In group A, periodontal surgery was performed. In group B, supportive periodontal therapy was administered. Clinical parameters including probing pocket depth, plaque index and circulating serum TNF-alpha levels were assessed at baseline and 16 weeks following treatment. RESULTS: There was a significant improvement in periodontal health of the surgery group compared with the control subjects, with reduction in plaque index and pocket probing depths. The circulating levels of TNF-alpha decreased statistically significantly in the group A (P < 0.05). CONCLUSION: Surgical periodontal therapy can reduce the circulating serum levels of TNF-t.