RESUMEN
Transforming growth factor-ß (TGF-ß) is released by activated platelets and induces the differentiation of T-helper 17 from naïve T cells. Contact between blood and cellulose acetate (CA) beads induces cytokine release, although their inflammatory effects on TGF-ß release are unclear. We aimed to clarify the effect of CA beads on the release of TGF-ß in vitro. We incubated peripheral blood with and without CA beads and measured platelets and TGF-ß. Compared with blood samples incubated without beads, the platelet count and amount of TGF-ß significantly decreased in blood samples incubated with CA beads. In conclusion, CA beads inhibited the release of TGF-ß from adsorbed platelets. The biological effects of this reduction of TGF-ß release during platelet adsorption to CA beads need further clarification.