1.
Chem Commun (Camb)
; 58(9): 1314-1317, 2022 Jan 27.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35005760
RESUMEN
Cell-penetrating poly(disulfide)s (CPDs) are promising vehicles for cytosolic delivery of proteins. However, currently available arginine-rich CPD has rarely been reported for systemic delivery due to its "always" positive charge. Herein, we developed pH-responsive CPDIMD that executes tumor targeting delivery via protonation of imidazole groups within the acidic tumor microenvironment.