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1.
J Nanosci Nanotechnol ; 14(3): 2648-52, 2014 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24745278

RESUMEN

FePt-Fe3O4 core-shell nanoparticles functionalized with 3,4-dihydroxyphenylacetic acid (DOPAC) and dimercaptosuccinic acid (DMSA) ligands were synthesized and characterized. We found that the DOPAC ligand enhances the magnetic properties of the FePt-Fe3O4 particles, in comparison with the DMSA ligand, which induces the oxidation of the shell layer that causes a significant reduction of the saturation magnetization. The synthesized magnetic nanoparticles were evaluated for applications in magnetic hyperthermia and magnetic resonance imaging contrast enhancement.


Asunto(s)
Compuestos Férricos/química , Hierro/química , Nanopartículas del Metal/química , Platino (Metal)/química , Ácido 3,4-Dihidroxifenilacético/química , Materiales Biocompatibles , Medios de Contraste/química , Ligandos , Imagen por Resonancia Magnética , Magnetismo , Microscopía Electrónica de Transmisión , Oxígeno/química , Solubilidad , Espectroscopía Infrarroja por Transformada de Fourier , Succímero/química , Temperatura , Agua/química
2.
Nat Mater ; 9(2): 165-71, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19946279

RESUMEN

Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental works so far have used superparamagnetic materials. This report describes a first approach based on interfacing cells with lithographically defined microdiscs that possess a spin-vortex ground state. When an alternating magnetic field is applied the microdisc vortices shift, creating an oscillation, which transmits a mechanical force to the cell. Because reduced sensitivity of cancer cells toward apoptosis leads to inappropriate cell survival and malignant progression, selective induction of apoptosis is of great importance for the anticancer therapeutic strategies. We show that the spin-vortex-mediated stimulus creates two dramatic effects: compromised integrity of the cellular membrane, and initiation of programmed cell death. A low-frequency field of a few tens of hertz applied for only ten minutes was sufficient to achieve approximately 90% cancer-cell destruction in vitro.


Asunto(s)
Magnetismo , Neoplasias/patología , Neoplasias/terapia , Anticuerpos Monoclonales/metabolismo , Materiales Biocompatibles/química , Materiales Biocompatibles/metabolismo , Calcio/metabolismo , Muerte Celular , Línea Celular Tumoral , Membrana Celular/metabolismo , Humanos , Espacio Intracelular/metabolismo , Fenómenos Mecánicos , Imagen Molecular , Neoplasias/metabolismo
3.
Sci Rep ; 8(1): 2907, 2018 02 13.
Artículo en Inglés | MEDLINE | ID: mdl-29440698

RESUMEN

Colloidal gold nanoparticles (AuNPs) are of interest as non-toxic carriers for drug delivery owing to their advanced properties, such as extensive surface-to-volume ratio and possibilities for tailoring their charge, hydrophilicity and functionality through surface chemistries. To date, various biocompatible polymers have been used for surface decoration of AuNPs to enhance their stability, payloads capacity and cellular uptake. This study describes a facile one-step method to synthesize stable AuNPs loaded with combination of two anticancer therapeutics, -bleomycin and doxorubicin. Anticancer activities, cytotoxicity, uptake and intracellular localization of the AuNPs were demonstrated in HeLa cells. We show that the therapeutic efficacy of the nanohybrid drug was strongly enhanced by the active targeting by the nanoscale delivery system to HeLa cells with a significant decrease of the half-maximal effective drug concentration, through blockage of HeLa cancer cell cycle. These results provide rationale for further progress of AuNPs-assisted combination chemotherapy using two drugs at optimized effective concentrations which act via different mechanisms thus decreasing possibilities of development of the cancer drug resistance, reduction of systemic drug toxicity and improvement of outcomes of chemotherapy.


Asunto(s)
Antineoplásicos/química , Doxorrubicina/química , Portadores de Fármacos/química , Oro/química , Nanopartículas del Metal/química , Antineoplásicos/farmacología , Doxorrubicina/farmacología , Células HeLa , Humanos , Tamaño de la Partícula , Polietilenglicoles/química
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