RESUMEN
The photoelastic effect has many uses in mechanics today, but it is usually disregarded in flexible materials. Using 2-phenoxyethyl acrylate as a monomer and 4-cyano-4'-pentylbiphenyl (5CB) as a solvent, a multiple responsive photoelastic organogel (PO) with strong birefringence but low modulus is created. 5CB is a liquid crystal molecule that does not participate in the polymerization process and is always present as tiny molecules in the polymer. It endows the PO low modulus and high birefringence, as well as the ability to drive the birefringence using an electric field. This PO not only has high sensitivity and fast response as a photoelastic strain sensor, but also has a very sensitive response to heat, especially in the range of human body temperature. It also has a high dielectric constant and a strong correlation between the interference color and the applied electric field, allowing for easy writing and erasure of encrypted data. This unique multisignal response feature and low modulus that mimics human skin bring up new opportunities in the potential applications such as multiple information encryption, anticounterfeiting, and multifunctional wearable sensors.
Asunto(s)
Cristales Líquidos , Acrilatos , Compuestos de Bifenilo , Humanos , Cristales Líquidos/química , Nitrilos , Polímeros , SolventesRESUMEN
Considering the omnipresence of microplastics (MPs) in aquatic environments, they are expected to exert significatn impacts as carriers for diverse waterborne pollutants. In this work, the adsorptive behavior of two ionic components (i.e., sodium dodecyl benzene sulfonate (SDBS) and Cr(VI)) has been explored against the two types of MPs as model adsorbents, namely poly (ethylene terephthalate) (PET) and polystyrene (PS). The influence of key variables (e.g., pH, particle size, and dose of the MPs) on their adsorption behavior is evaluated from various respects. The maximum adsorption capacity values of SDBS on PET and PS are estimated to be 4.80 and 4.65 mgâ g-1, respectively, while those of Cr(VI) ions are significantly lower at 0.080 and 0.072 mgâ g-1, respectively, The adsorptive equilibrium of SDBS is best described in relation to pH and MP size by a Freundlich isotherm. In contrast, the adsorption behavior of Cr(VI) is best accounted for by a Langmuir isotherm to indicate its adsorption across at least two active surface sites.
Asunto(s)
Microplásticos , Contaminantes Químicos del Agua , Adsorción , Bencenosulfonatos , Cromo , Concentración de Iones de Hidrógeno , Cinética , Plásticos , Contaminantes Químicos del Agua/análisisRESUMEN
Effective treatment of brain metastases is hindered by the blood-brain barrier (BBB) and the rapid development of resistance to drug therapy. Moreover, the clinical application of general formulations is hampered by biological barriers and biological elimination. To tackle this challenge, we report a feasible approach for the assembly of polymer-covalent organic framework (COF) nanocomposites into 150 nm thin platelets as a drug delivery vehicle for enhanced retention in brain tumours. Using intravital imaging, we demonstrate that these polymer-COF nanocomposites are able to traverse the BBB in mice and achieve direct tumour accumulation in intracranial orthotopic models of brain metastasis from renal cancer (BMRC). These nanocomposites can target brain tumour cells and respond to tumour microenvironmental characteristics, including acidic and redox conditions. Intracranial tumour acidity triggers the breakdown of the nanoassemblies to polymer-COF nanocomposites due to the presence of borate bonds. Furthermore, in vivo studies on the nanocomposites showed enhanced brain tumour-targeting efficiency and therapeutic effects compared to those of free-drug dosing. Mice treated with drug-loaded polymer-COF nanocomposites also show protection from systemic drug toxicity and improved survival, demonstrating the preclinical potential of this nanoscale platform to deliver novel combination therapies to BMRC and other central nervous system (CNS) tumours.
Asunto(s)
Antineoplásicos/farmacología , Barrera Hematoencefálica/efectos de los fármacos , Neoplasias Encefálicas/tratamiento farmacológico , Neoplasias Renales/tratamiento farmacológico , Estructuras Metalorgánicas/farmacología , Nanocompuestos/química , Polímeros/farmacología , Animales , Antineoplásicos/química , Barrera Hematoencefálica/metabolismo , Barrera Hematoencefálica/patología , Neoplasias Encefálicas/metabolismo , Neoplasias Encefálicas/secundario , Línea Celular , Proliferación Celular/efectos de los fármacos , Ensayos de Selección de Medicamentos Antitumorales , Neoplasias Renales/metabolismo , Neoplasias Renales/patología , Estructuras Metalorgánicas/química , Ratones , Ratones Endogámicos BALB C , Neoplasias Experimentales/tratamiento farmacológico , Neoplasias Experimentales/metabolismo , Neoplasias Experimentales/patología , Tamaño de la Partícula , Polímeros/química , Propiedades de Superficie , Microambiente Tumoral/efectos de los fármacosRESUMEN
Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcumin derivatives (PEG-CCM) and amine-functionalized COFs (APTES-COF-1) for in vitro and in vivo drug delivery. The real-time fluorescence response shows efficient tracking of the COF-based materials upon cellular uptake and anticancer drug (doxorubicin (DOX)) release. Notably, in vitro and in vivo studies demonstrate that PEG-CCM@APTES-COF-1 is a smart carrier for drug delivery with superior stability, intrinsic biodegradability, high DOX loading capacity, strong and stable fluorescence, prolonged circulation time and improved drug accumulation in tumors. More intriguingly, PEG350-CCM@APTES-COF-1 presents an effective targeting strategy for brain research. We envisage that PEG-CCM@APTES-COF-1 nanocomposites represent a great promise toward the development of a multifunctional platform for cancer-targeted in vivo drug delivery.