Profiling patient-reported symptom recovery from oesophagectomy for patients with oesophageal squamous cell carcinoma: a real-world longitudinal study.

PURPOSE: Oesophageal squamous cell carcinoma (ESCC) patients have severe symptom burden after oesophagectomy; however, longitudinal studies of symptom recovery after surgery are scarce. This study used longitudinal patient-reported outcome (PRO)-based symptoms to identify severe symptoms and profile symptom recovery from surgery in patients undergoing oesophagectomy. METHODS: Oesophageal cancer patients (N = 327) underwent oesophagectomy were consecutively included between April 2019 and March 2020. Data were extracted from the Sichuan Cancer Hospital's Esophageal Cancer Case Management Registration Database. Symptom assessment time points were pre-surgery and 1, 3, 5, 7, 14, 21, 30, and 90 days post-surgery using the Chinese version of the MD Anderson Symptom Inventory. And each symptom was rated on an 11-point scale, with 0 being 'not present' and 10 being 'as bad as you can imagine'. The symptom recovery trajectories were profiled using mixed effect models and Kaplan-Meier analysis. RESULTS: The most-severe symptoms on day 1 after oesophagectomy were pain, fatigue, dry mouth, disturbed sleep, and distress. The severity of symptoms peaked on day 1 after surgery. The top two symptoms were fatigue (mean: 5.44 [SD 1.88]) and pain (mean: 5.23 [SD 1.29]). Fatigue was more severe 90 days after surgery than at baseline (mean: 1.77 [SD 1.47] vs 0.65 [SD 1.05]; P < .0001). Disturbed sleep and distress persisted from pre-surgery to 90 days post-surgery; average sleep recovery time was up to 20 days, and 50.58% of patients had sleep disturbances 90 days post-surgery. CONCLUSIONS: Early post-operative pain management after oesophagectomy should be considered. Characteristics and intervention strategies of post-operative fatigue, distress, and disturbed sleep in oesophageal cancer patients warrant further studies.

The cross-sectional effects of ribbon arch wires on Class II malocclusion intermaxillary traction: a three-dimensional finite element analysis.

BACKGROUND: The application of intermaxillary traction is often accompanied by the unexpected movement of dentition, especially anchorage teeth. The aim of this study was to comprehensively compare the influence of cross-sectional shape of ribbon arch wires with edgewise and round wires on intermaxillary traction in Class II malocclusion treatment using FEA simulation. METHODS: The dentofacial structure was simulated in finite element software. A retraction force of 1.5 N was applied to different cross-sectional orthodontic arch wires: a ribbon wire (0.025 × 0.017-in. and 0.025 × 0.019-in.), a rectangular wire (0.017 × 0.025-in. and 0.019 × 0.025-in.) and a round wire (Φ 0.018-in. and Φ 0.020-in.). RESULTS: Among the three groups, ribbon wire (0.025 × 0.017-in. and 0.025 × 0.019-in.) exhibited the lowest displacement in the X-axis (12.61 µm and 12.77 µm, respectively) and Z-axis (8.99 µm and 9.06 µm, respectively). However, the 0.025 × 0.017-in. ribbon wire showed the highest Y-axis displacement. In the round wire group, Φ 0.020-in. wire displayed less rotation than Φ 0.018-in. wire, where the sagittal, frontal and occlusal rotation of Φ 0.020-in. wire was almost half of that of Φ 0.018-in. wire. The movement of the first molar region was intermediate between the ribbon arch group and the round wire group. Notably, the values of the 0.025 × 0.017-in. arch wire displacement, which were higher than those of any other group, peaked at 0.019 mm in the central incisor region with a spike-like shape. The deformation range of the Φ 0.018-in. wire group was the largest in this study. CONCLUSIONS: The cross-section of the arch wire influenced force delivery in Class II intermaxillary traction. With the same shape, a larger cross-sectional area led to less mandibular dentition movement. For the rectangular arch wire and ribbon arch wire groups, since the height and width were inverted, the vertical displacement of anchorage teeth in the ribbon wire group was reduced, but the possibility of buccal tipping in mandibular anterior teeth also increased.

Advantages of Totally Stapled Collard Over Circular Stapled Technique for Cervical Esophagectomy Anastomosis.

BACKGROUND: The quality of life between the totally stapled Collard (TSC) and circular stapled (CS) techniques from the patient's perspective has not been assessed. This longitudinal patient-reported outcome and objective data assessment study aimed to compare the effects of TSC vs CS for cervical anastomosis with minimally invasive esophagectomy (MIE) on the quality of life. METHODS: This single-center, retrospective study included patients with esophageal cancer who underwent MIE and cervical anastomosis between April 2019 and February 2021; of whom, 105 and 216 patients received TSC and CS anastomosis, respectively. The objective metrics were evaluated based on postoperative complications. Patient-reported outcomes instruments using the European Organization for Research and Treatment of Cancer modules were assessed preoperatively. The Quality of Life Questionnaire (QLQ) Core 30 and the QLQ-Oesophagus Module 18 assessed the quality of life. Mixed-effects models examined changes in questionnaire scores. RESULTS: The stenosis rate in the TSC group was significantly lower than that in the CS group. There were no significant differences in other postoperative complications between the groups. In the QLQ Core 30 scale, the TSC group had better emotional function, less fatigue, less appetite loss, and better function than the CS group, with significant differences in different time points between the groups. QLQ-Oesophagus Module 18 revealed that the TSC group had significantly less appetite loss, dysphagia, dry mouth, pain, and obstruction, and better eating and speech than the CS group. CONCLUSIONS: TSC has significant advantages over the CS technique in lowering postoperative symptom burden and improving quality of life for cervical anastomosis on patient-reported outcomes.

WITHDRAWN: Minocycline hydrochloride combined with invisible and fixed orthodontic treatment improves periodontal health in periodontitis patients by reducing microRNA-146a levels.

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[Effect of different adduction methods of maxillary incisor in adolescents on the shape of alveolar bone].

PURPOSE: To explore the influence of different adduction methods of maxillary incisor in adolescents on the shape of alveolar bone. METHODS: Three hundred and twenty-eight maxillary incisors were collected from 82 patients with jaw protrusion deformity treated in Union Hospital of Fujian Medical University from June 2018 to June 2019. 135 incisors were included in the oblique adduction group, and 193 incisors were included in the root control adduction group. All patients took cone-beam CT(CBCT) to measure the adduction of the maxillary incisor and the changes in alveolar bone height, thickness, and bone density. Statistical analysis was performed with SPSS 18.0 software package. RESULTS: The length of the maxillary incisor to the mid-palatine vertical surface(IE-MP), the long axis of the maxillary incisor and the posterior inferior angle of the palatal plane (LAI-PP) in oblique adduction group were significantly greater than root control adduction group(P＜0.05). The length of the maxillary incisor from the apex of the maxillary incisor to the mid-palatine vertical surface(RA-MP) in the oblique adduction group was significantly smaller than the root control adduction group (P＜0.05). Postoperative L1, L2, L3, P1, T1 of the oblique adduction group were significantly lower than preoperative values(P＜0.05), and postoperative P2, P3, T2, and T3 were significantly higher than preoperative value(P＜0.05). Postoperative L1, L2, and L3 of the root control adduction group were significantly higher than those before operation (P＜0.05), and postoperative P1, P2, P3, T1, T2, and T3 were significantly lower than those before operation(P＜0.05). The changes of L2, L3, P3, T3 of the oblique adduction group were significantly higher than the control root adduction group(P＜0.05), and the changes of L1, P1, P2, T1, T2 of the oblique adduction group were all significantly lower than the control root adduction group(P＜0.05). There was no significant difference in bone mineral density of the upper and lower jaws between the two groups before and 6 months after operation(P＞0.05). CONCLUSIONS: When adolescents' maxillary incisors are retracted in a wide range, the labial apical area, the palatal alveolar ridge area of the oblique adduction group, and the palatal root neck of the root control adduction group are all high-risk areas for alveolar bone resorption.

Synthesis and growth mechanism of selenium nanowire bundles via a polymer-controlled chemical route.

This article describes a polymer-controlled chemical method for synthesis of trigonal selenium (t-Se) nanowire bundles in the presence of poly(vinyl alcohol) (PVA) at 100 degrees C. Electron microscope images show that Se nanowires have diameters of 30-50 nm and lengths of up to a few tens of micrometers. TEM images display the direct evidence for the growth process of single-crystalline Se nanowire bundles, which suggested that Se nanowire bundles were directly converted from the initial amorphous Se micro-particles in the presence of PVA. UV-Vis absorbance of t-Se nanowire bundles revealed that the bandgap and absorbance peaks displayed larger blue shifts relative to those of bulk t-Se.