Simultaneous Improvement of Oxidative and Hydrolytic Resistance of Polycarbonate Urethanes Based on Polydimethylsiloxane/Poly(hexamethylene carbonate) Mixed Macrodiols.

The degradation behaviors including oxidation and hydrolysis of silicone modified polycarbonate urethanes were thoroughly investigated. These polyurethanes were based on polyhexamethylene carbonate (PHMC)/polydimethylsiloxane (PDMS) mixed macrodiols with molar ratio of PDMS ranging from 5% to 30%. It was proved that PDMS tended to migrate toward surface and even a small amount of PDMS could form a silicone-like surface. Macrophages-mediated oxidation process indicated that the PDMS surface layer was desirable to protect the fragile soft PHMC from the attack of degradative species. Hydrolysis process was probed in detail after immersing in boiling buffered water using combined analytical tools. Hydrolytically stable PDMS could act as protective shields for the bulk to hinder the chain scission of polycarbonate carbonyls whereas the hydrolysis of urethane linkages was less affected. Although the promoted phase separation at higher PDMS fractions lead to possible physical defects and mechanical compromise after degradation, simultaneously enhanced oxidation and hydrolysis resistance could be achieved for the polyurethanes with proper PDMS incorporation.

Synthetic Lignin-Derived Therapeutic Nano Reagent as Intestinal pH-Sensitive Drug Carriers Capable of Bypassing the Gastric Acid Environment for Colitis Treatment.

Oral drug delivery is a common route for management of inflammatory bowel disease (IBD) but suffers from low bioavailability and systemic side effects during passage through the alimentary canal. Here, we present a therapeutic nano reagent of a ferulic acid-derived lignin nanoparticle (FALNP). We showed that FALNP with favorable antioxidant activity can regulate IBD. More importantly, the intestinal pH-responsive degradability of FALNP allows it to withstand the harsh gastric acid environment, bypass physiological barriers, and target the intestine for gastrointestinal delivery. In vivo experiments showed that oral administration of FALNP markedly relieved pathological symptoms in a mouse model of acute colitis by reducing oxidative stress and regulating the gut microbiome. By integrating anti-inflammatory medicine, FALNP also can be used as a bioactive carrier to exert a potent synergistic therapeutic effect. In addition to colitis, FALNP can be readily adaptable for use as a carrier platform for therapy of many other intestinal diseases.

Smartphone-assisted ratiometric fluorescence sensing platform and logical device based on polydopamine nanoparticles and carbonized polymer dots for visual and point-of-care testing of glutathione.

As a crucial biothiol, glutathione (GSH) plays a key role in the organisms. Monitoring GSH level is of great significance for disease diagnosis and biomedical research. In this work, polydopamine (PDA) nanoparticles-red fluorescent carbonized polymer dots (r-CPDs) based ratiometric fluorescence sensing platform was constructed and employed for GSH assay. Dopamine (DA) could be oxidized by cobalt oxyhydroxide (CoOOH) nanosheets and further polymerized into PDA nanoparticles with green fluorescence. However, in the presence of GSH, CoOOH nanosheets were reduced and decomposed, which prevented the production of PDA nanoparticles. In the sensing system, green-emitting PDA nanoparticles were employed as a response unit and r-CPDs were used as an internal reference unit. With the addition of GSH, the green fluorescence of PDA nanoparticles decreased as well as the red fluorescence of system remained relatively stable. Importantly, a distinct fluorescence color evolution from green to red was presented with a serious of GSH concentrations. Based on this, a portable smartphone-assisted ratiometric chromaticity analytical method was developed to achieve the on-site visual detection of GSH. Both the established ratiometric fluorescence and ratiometric chromaticity sensing methods for GSH assay have the merits of wide linear range, high sensitivity and excellent accuracy, which are suitable for the determination of GSH in human serum and exhibit great application potential in rapid and accurate monitoring of the GSH levels in clinical. Moreover, an ingenious logical device reflecting GSH levels was designed based on the two different fluorescence signals, which provided a new strategy for the intelligent online detection of GSH in complex biological matrices.

In situ hydrothermal synthesis of tetrazole coordination polymers with interesting physical properties.

Tetrazole compounds have been studied for more than one hundred years and applied in various areas. Several years ago Sharpless and his co-workers reported an environmentally friendly process for the preparation of 5-substituted 1H-tetrazoles in water with zinc salt as catalysts. To reveal the exact role of the zinc salt in this reaction, a series of hydrothermal reactions aimed at trapping and characterizing the solid intermediates were investigated. This study allowed us to obtain a myriad interesting metal-organic coordination polymers that not only partially showed the role of the metal species in the synthesis of tetrazole compounds but also provided a class of complexes displaying interesting chemical and physical properties such as second harmonic generation (SHG), fluorescence, ferroelectric and dielectric behaviors. In this tutorial review, we will mainly focus on tetrazole coordination compounds synthesized by in situ hydrothermal methods. First, we will discuss the synthesis and crystal structures of these compounds. Their various properties will be mentioned and we will show the applications of tetrazole coordination compounds in organic synthesis. Finally, we will outline some expectations in this area of chemistry. The direct coordination chemistry of tetrazoles to metal ions and in situ synthesis of tetrazole through cycloaddition between organotin azide and organic cyano group will be not discussed in this review.