Multi-scale hybrid modified coatings on titanium implants for non-cytotoxicity and antibacterial properties.

Titanium and its alloys are among the widely used materials in the biomedical field, but they have poor wear resistance and antibacterial properties. In the present study, anodization, photo-reduction, and spin-coating technologies were integrated to prepare a hybrid modified coating for bio-inert titanium implants, having excellent comprehensive performance. The surface roughness of Ti-35Nb-2Ta-3Zr was specifically optimized by surface modification leading to improved wear resistance. Ag ions are still detectable after 28 days of submersion in saline. The antibacterial rate of the composite coating group reaches 100% by plate counting due to the antibacterial mechanism of direct and indirect contact. Both bacteria morphology and fluorescence staining experiments confirm these results. Besides, no cytotoxicity was detected in our fabricated implants during the CCK-8 assay. Accordingly, fabrication of hybrid modified coatings on Ti-35Nb-2Ta-3Zr is an effective strategy for infection and cytotoxicity prevention. These hybrid modified coatings can be regarded as promising multifunctional biomaterials.

Influence of Nb on the ß→α″ martensitic phase transformation and properties of the newly designed Ti-Fe-Nb alloys.

A series of Ti-7Fe-xNb (x=0, 1, 4, 6, 9, 11 wt.%) alloys was designed and cast to investigate the ß→α″ martensitic phase transformation, ß phase stability, the resulting microstructure and mechanical properties. Phase analysis revealed that only Ti-7Fe-11Nb alloy shows a single body-centred cubic ß phase microstructure while the others are comprised of ß and orthorhombic α″ phases. Moreover, Nb addition up to 11 wt.% enhances the stability and volume fraction of ß phase in the microstructure, hence reducing the propensity of the alloy system to form α″ phase during quenching. Compressive yield strength and hardness of the alloys are (985-1847) MPa and (325-520) Hv respectively. Additionally, Ti-7Fe-11Nb possesses the lowest Young's modulus (84 GPa) and the highest deformability (42% strain) among the designed alloys due to the single ß phase microstructure. This high deformability is also corroborated by the large plastic deformation zone underneath the Vickers indenter. In contrast, the fractured surfaces of Ti-7Fe and Ti-7Fe-1Nb alloys after compressive tests mostly contain shallow dimples, verifying their low ductility. The good combination of mechanical properties obtained for Ti-7Fe-11Nb renders it more desirable than commonly used CP-Ti and Ti-6Al-4V materials and makes it a promising candidate for biomedical application.

Architectural design of diamond-like carbon coatings for long-lasting joint replacements.

Surface engineering through the application of super-hard, low-friction coatings as a potential approach for increasing the durability of metal-on-metal replacements is attracting significant attention. In this study innovative design strategies are proposed for the development of diamond-like-carbon (DLC) coatings against the damage caused by wear particles on the joint replacements. Finite element modeling is used to analyze stress distributions induced by wear particles of different sizes in the newly-designed coating in comparison to its conventional monolithic counterpart. The critical roles of architectural design in regulating stress concentrations and suppressing crack initiation within the coatings is elucidated. Notably, the introduction of multilayer structure with graded modulus is effective in modifying the stress field and reducing the magnitude and size of stress concentrations in the DLC diamond-like-carbon coatings. The new design is expected to greatly improve the load-carrying ability of surface coatings on prosthetic implants, in addition to the provision of damage tolerance through crack arrest.