RESUMEN
To take advantage of high surface area of network conjugated microporous polymers, four linear or network conjugated polymers L-PDBT, L-PDBT-O, N-PDBT, and N-PDBT-O are designed in terms of water-compatibility, and it turned out that microporous network N-PDBT-O exhibited the highest hydrogen evolution rate (HER) at 366 µmol h-1 under visible light irradiation (λ > 420 nm, one of best reported pristine polymer-based photocatalysts), which is three times higher than the corresponding linear L-PDBT-O. Water contact angle measurements revealed that benzothiophene-sulfone-based conjugated polymers display better water compatibility and adsorption, and the synergic effect of better hydrophilic surface and higher surface area of N-PDBT-O might eventually lead to more exposed active sites in comparison to linear L-PDBT-O in the H2 evolution suspension system. The hydrophilicity-controlled strategy could be applied to design of other network conjugated microporous polymer photocatalysts in an attempt to improve the activity.
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Hidrógeno/química , Luz , Polímeros/química , Catálisis , Interacciones Hidrofóbicas e Hidrofílicas , Tamaño de la Partícula , Procesos Fotoquímicos , Polímeros/síntesis química , Porosidad , Sulfonas/química , Propiedades de Superficie , Tiofenos/químicaRESUMEN
A novel cellulose composite (denoted as PEI@MMA-1) with porous interconnected structure was prepared by adsorbing methyl cellulose (MC) onto microcrystalline cellulose (MCC) and cross-linking polyethyleneimine (PEI) with MCC by the action of epichlorohydrin, which had the excellent adsorption property, wettability and elasticity. The performances of PEI@MMA-1 composite for removing tetracycline (TC), Cu2+ and coexistent pollutant (TC and Cu2+ mixture) were systematically explored. For single TC or Cu2+ contaminant, the maximum adsorption capacities were 75.53 and 562.23 mg/g at 30 °C, respectively, while in the dual contaminant system, they would form complexes and Cu2+ could play a "bridge" role to remarkably promote the adsorption of TC with the maximum adsorption capacities of 281.66 and 253.58 mg/g for TC and Cu2+. In addition, the adsorption kinetics, isotherms and adsorption mechanisms of single-pollutant and dual-pollutant systems have been thoroughly investigated. Theoretical calculations indicated that the amide group of TC molecule with the assistance of Cu2+ interacted with the hydroxyl group of PEI@MMA-1 composite to enhance the TC adsorption capacity. Cycle regeneration and fixed bed column experiments revealed that the PEI@MMA-1 possessed the excellent stability and utility. Current PEI@MMA-1 cellulose composite exhibited a promising application for remediation of heavy metals and antibiotics coexistence wastewater.
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Celulosa/análogos & derivados , Cobre , Polietileneimina/análogos & derivados , Contaminantes Químicos del Agua , Cobre/química , Adsorción , Contaminantes Químicos del Agua/química , Tetraciclina/química , Antibacterianos , Iones , CinéticaRESUMEN
Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) are two major causative agents of hand, foot, and mouth disease (HFMD) in young children. However, the mechanisms regulating the replication and pathogenesis of EV71/CVA16 remain incompletely understood. We performed a genome-wide CRISPR-Cas9 knockout screen and identified Ragulator as a mediator of EV71-induced apoptosis and pyroptosis. The Ragulator-Rag complex is required for EV71 and CVA16 replication. Upon infection, the Ragulator-Rag complex recruits viral 3D protein to the lysosomal surface through the interaction between 3D and RagB. Disruption of the lysosome-tethered Ragulator-Rag-3D complex significantly impairs the replication of EV71/CVA16. We discovered a novel EV71 inhibitor, ZHSI-1, which interacts with 3D and significantly reduces the lysosomal tethering of 3D. ZHSI-1 treatment significantly represses replication of EV71/CVA16 as well as virus-induced pyroptosis associated with viral pathogenesis. Importantly, ZHSI-1 treatment effectively protects against EV71 infection in neonatal and young mice. Thus, our study indicates that targeting lysosome-tethered Ragulator-Rag-3D may be an effective therapeutic strategy for HFMD.
Asunto(s)
Enterovirus Humano A , Enfermedad de Boca, Mano y Pie , Proteínas no Estructurales Virales , Animales , Ratones , Apoptosis , Sistemas CRISPR-Cas , Enterovirus Humano A/genética , Lisosomas , Piroptosis , Proteínas no Estructurales Virales/genética , Replicación Viral , Enfermedad de Boca, Mano y Pie/virología , Modelos Animales de EnfermedadRESUMEN
PURPOSE: To discuss a new classification and the treatment principles of synovial chondromatosis (SC) in the inferior compartment of the temporomandibular joint (TMJ). PATIENTS AND METHODS: Five cases of SC in the inferior compartment were treated in an open manner between January 2008 and May 2011. Each case had different clinical and radiologic aspects and was treated with different surgical therapies. SC in the inferior compartment of the TMJ is classified into 3 stages. All patients were evaluated by computed tomography, magnetic resonance imaging, and clinical manifestations preoperatively and postoperatively. RESULTS: There were 3 kinds of manifestation modes from radiologic findings. Case 1 was in stage 1, in which multiple loose bodies are noted without bony erosion. This patient was treated by removal of loose bodies and affected synovium. Case 2 was in stage 2, in which multiple calcified nodules were conglutinated to the condyle; the condyle was enlarged with pressure erosions. This patient was treated by condylectomy and reconstruction with costochondral graft. Case 3, case 4, and case 5 were all in stage 3, in which the condyle was destroyed as a result of pressure erosions or by direct bony invasion of the mass and the inferior surface of the disc was involved. These patients were treated by condylectomy together with discectomy, as well as reconstruction with costochondral graft and pedicled deep temporal fascial fat flap. No recurrence occurred. The height of the ramus and the occlusion were maintained in the same condition as preoperatively. CONCLUSIONS: Our new classification of SC in the inferior compartment of the TMJ can better guide clinical treatment.
Asunto(s)
Condromatosis Sinovial/clasificación , Trastornos de la Articulación Temporomandibular/clasificación , Tejido Adiposo/trasplante , Adulto , Artroplastia de Reemplazo/métodos , Calcinosis/clasificación , Calcinosis/cirugía , Cartílago/trasplante , Condromatosis Sinovial/cirugía , Fascia/trasplante , Femenino , Estudios de Seguimiento , Humanos , Hipertrofia , Cuerpos Libres Articulares/clasificación , Cuerpos Libres Articulares/cirugía , Imagen por Resonancia Magnética , Masculino , Cóndilo Mandibular/patología , Cóndilo Mandibular/cirugía , Persona de Mediana Edad , Procedimientos de Cirugía Plástica/métodos , Sinovectomía , Disco de la Articulación Temporomandibular/patología , Disco de la Articulación Temporomandibular/cirugía , Trastornos de la Articulación Temporomandibular/cirugía , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
OBJECTIVE: This article studies the classification of traumatic temporomandibular joint (TMJ) ankylosis based on coronal computed tomographic (CT) scan and presents our treatment experience in the TMJ division of Shanghai Ninth People's Hospital. PATIENTS AND METHODS: From 2001 to 2009, 130 patients diagnosed with TMJ ankylosis were treated in the TMJ division. Among them, 84 patients with 124 joint injuries caused by trauma were treated first by our group of surgeons and were included in this study. All of them had CT scans, especially coronal reconstruction through the TMJ area before and after surgery. A new classification based on the coronal CT scan was proposed: type A1 is fibrous ankylosis without bony fusion of the joint; type A2 is ankylosis with bony fusion on the lateral side of the joint, while the residual condyle fragment is bigger than 0.5 of the condylar head in the medial side; type A3 is similar to A2 but the residual condylar fragment is smaller than 0.5 of the condylar head; type A4 is ankylosis with complete bony fusion of the joint. Our treatment protocol for type A1 ankylosis is fibrous tissue release or condylar head resection with costochondral graft (CCG) and temporalis myofascial flap (TMF). For type A2 and A3 ankylosis, the lateral bony fusion is resected, while the intact residual condylar fragment, displaced medially, is retained. We call it "lateral arthroplasty" (LAP). TMF or masseter muscle flap (MMF) is used as a barrier in the lateral gap between the TMJ fossa and the stump of the mandibular ramus. If the medial condylar fragment in type A3 ankylosis is too small to bear the load, it is resected with the bony mass. The joint is then reconstructed with CCG and TMF or MMF. For type A4 ankylosis, the bony fusion is completely removed and the joint is reconstructed with CCG and TMF or MMF. The result of the treatment was evaluated by CT scan and clinical follow-up. RESULTS: Among the 124 ankylotic joints, there were 14 type A1 ankylosis (11.3%); 43 type A2 ankylosis (34.7%); 46 type A3 ankylosis (37.1%); and 21 type A4 ankylosis (16.9%). Part of type A1, and all of type A2 and A3 ankylosis had the residual condylar head displaced medially, which accounted for 75% (93/124) of the TMJ ankylosis. Eighty-two joints (66.1%) had LAP treatment; 33 joints (26.6%) had CCG joint reconstruction; and 3 joints (2.4%) had TMJ fibrous tissue release. In our case, 1 joint (0.8%) had condylectomy and TMF; 3 joints (2.4%) with fibrous ankylosis had mouth opening treatment; and 2 joints had gap arthroplasty (1.6%). Forty-eight patients with 68 joints had long follow-ups from 10 months to 4 years. Among them, 4 of 17 joints reconstructed with CCG had reankylosis (23.5%), and 7 of 48 joints treated with LAP had reankylosis (14.6%). CONCLUSIONS: The new classification of TMJ ankylosis based on coronal CT scan is valuable in guiding clinical treatment. LAP with TMF is a good way to treat traumatic TMJ ankylosis when the medially displaced condylar head and disc are intact. CCG with TMF has a good result for type A4 ankylosis.
Asunto(s)
Anquilosis/cirugía , Trastornos de la Articulación Temporomandibular/cirugía , Articulación Temporomandibular/lesiones , Adolescente , Adulto , Anciano , Anquilosis/clasificación , Anquilosis/diagnóstico por imagen , Anquilosis/etiología , Anquilosis/patología , Niño , Preescolar , Femenino , Humanos , Masculino , Persona de Mediana Edad , Recurrencia , Articulación Temporomandibular/diagnóstico por imagen , Articulación Temporomandibular/patología , Articulación Temporomandibular/cirugía , Trastornos de la Articulación Temporomandibular/diagnóstico por imagen , Trastornos de la Articulación Temporomandibular/etiología , Trastornos de la Articulación Temporomandibular/patología , Tomografía Computarizada por Rayos X , Adulto JovenRESUMEN
Temporomandibular joint (TMJ) ankylosis during early childhood always produces alteration of the mandibular growth with facial asymmetry, chin deviation, and malocclusion. The younger the ankylosis happens, the more severe the facial deformity presents. When TMJ ankylosis occurs in infancy, there might be a delay in diagnosis and treatment. In this article, we describe a case of TMJ ankylosis in a 10-month-old boy. The etiology was indistinct. Surgical plan including modified gap arthroplasty, costochondral graft (CCG), temporalis fascial flap, was preformed to this patient. The joint and the mandibular ramus were restored. No severe complication occurred. There was no recurrence of ankylosis and further developing of mandibular asymmetry during 2-year follow-up period.
Asunto(s)
Anquilosis/cirugía , Asimetría Facial/cirugía , Enfermedades Mandibulares/cirugía , Trastornos de la Articulación Temporomandibular/cirugía , Artroplastia/métodos , Cartílago/trasplante , Fascia/trasplante , Estudios de Seguimiento , Humanos , Lactante , Masculino , Cóndilo Mandibular/cirugía , Rango del Movimiento Articular/fisiología , Procedimientos de Cirugía Plástica/métodos , Colgajos Quirúrgicos , Músculo Temporal/trasplanteRESUMEN
The rheological properties of nanocomposites consisting of organic modified attapulgite and polypropylene are investigated. The morphology of the nanocomposites was studied with scanning electron microscopy and X-ray diffraction. Linear dynamic viscoelasticity and steady state flow step of the nanocomposites are presented. For the nanocomposites, the deviation from linear behavior occurs earlier than pure polypropylene at the strain. The storage moduli, loss moduli and dynamic viscosities of the nanocomposites increase monotonically with organoclay concentration. However, the nanocomposites show greater shear thinning tendency than pure polypropylene because of the orientation of the organoclay fibers. Therefore, the nanocomposites have higher moduli but better processibility compared with pure polypropylene.
Asunto(s)
Compuestos de Magnesio/química , Nanocompuestos/química , Polipropilenos/química , Compuestos de Silicona/química , Microscopía Electrónica de Rastreo , Reología/métodos , Viscosidad , Difracción de Rayos XRESUMEN
PURPOSE: This article reports a modified preauricular approach for intracapsular condyle fracture (ICF) of the mandible and evaluates the stability of various internal fixation methods in the temporomandibular joint (TMJ) division of the Shanghai Ninth People's Hospital. MATERIALS AND METHODS: One hundred fifty-one patients with 208 ICFs diagnosed by panoramic radiograph and computed tomographic (CT) scan received open treatment in the TMJ division from 1999 to 2008. Their charts were reviewed. Classification of the fracture was based on coronal CT scan. Forty-three patients also underwent magnetic resonance imaging before the operation to check displacement of the disc. A modified preauricular approach was used for all patients. Various internal fixation methods from wire, to screw, to plate were evaluated for stability. RESULTS: There were 110 ICFs of type A fracture, 60 of type B fracture, 9 of type C fracture, 25 of type M fracture, and 4 fractures without displacement. A modified preauricular approach was used for open treatment, which can better expose and protect the TMJ and superficial temporal vessels. Wire and plate is the commonly used stable fixation method for type A, B, and M fractures, which accounted for 56.7% (101/178). Small fracture fragments were removed with disc repositioning for all type C fractures (n = 9) and some type B (n = 9) and M fractures (n = 5). Three type M fracture and 3 nondisplaced ICFs were treated closed. Eighty-nine patients with 115 ICFs had postoperative CT scan, which showed anatomic and nearly anatomic fracture reduction rates of 95.6%. Thirty-five patients with 44 ICFs had long-term follow-ups from 3 months to 5 years. Among them, 63.2% (n = 12/19) pediatric ICFs had continuous condyle growth after open reduction and rigid fixation; 92% adults had ICFs that healed well (n = 23/25). Postoperative complications were facial nerve injury (n = 3), TMJ clicking (n = 1), and condyle resorption that required plate removal (n = 4). CONCLUSION: A modified preauricular approach provides better exposure and protection of the TMJ and superficial temporal vessels. Wire and plate provides stable fixation for type A and some type B and M fractures. Open reduction and rigid fixation produce good results for adult patients.
Asunto(s)
Fijación Interna de Fracturas/métodos , Fijadores Internos , Cóndilo Mandibular/cirugía , Fracturas Mandibulares/cirugía , Procedimientos Ortopédicos/métodos , Adulto , Fenómenos Biomecánicos , Femenino , Estudios de Seguimiento , Fijación Interna de Fracturas/instrumentación , Humanos , Cápsula Articular/cirugía , Masculino , Cóndilo Mandibular/lesiones , Fracturas Mandibulares/clasificación , Estudios Retrospectivos , Articulación Temporomandibular/cirugía , Resultado del TratamientoRESUMEN
This study was aimed at elucidating the changes of mandible symmetry in a rabbit model with low estrogen levels induced by ovariectomy (OVX) combined with temporomandibular joint (TMJ) anterior disc displacement without reduction (ADDWoR). 32 growing rabbits were randomly allocated into 4 groups; OVX group, ADDWoR group, OVX+ ADDWoR group and control group. In OVX and OVX+ ADDWoR groups, bilateral OVX was performed and then the serum level of 17ß-estradiol was evaluated every week. In ADDWoR group and OVX+ ADDWoR group, the right TMJ was surgically opened and the disc was displaced anteriorly and the left TMJ was also surgically opened and closed without any manipulation of the disc. All rabbits had CT scan before and at the end of the study and the mandible measurements were performed on the 3D-reconstructed model. The mandible in ADDWoR group was consistently shorter on the right side resulting in a midline shift to the ipsilateral side. While in OVX+ ADDWoR group, the mandibular length of the right side was more shorter than in ADDWoR group, moreover, mandibular deviation was therefore more severe. In OVX group, there was no difference regarding the length of mandible compared to the control group. There was no difference regarding the mandibular length between left and right sides in the control group.
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Estrógenos/metabolismo , Cara/patología , Mandíbula/patología , Trastornos de la Articulación Temporomandibular/patología , Articulación Temporomandibular/patología , Animales , Peso Corporal , Estrógenos/sangre , Femenino , Mandíbula/cirugía , Conejos , Articulación Temporomandibular/cirugía , Trastornos de la Articulación Temporomandibular/sangre , Trastornos de la Articulación Temporomandibular/cirugíaAsunto(s)
Leucemia Mieloide Aguda/complicaciones , Cóndilo Mandibular/patología , Neoplasias Mandibulares/patología , Sarcoma Mieloide/patología , Trastornos de la Articulación Temporomandibular/patología , Adolescente , Antineoplásicos/uso terapéutico , Clavícula/diagnóstico por imagen , Clavícula/cirugía , Color , Femenino , Humanos , Leucemia Mieloide Aguda/tratamiento farmacológico , Leucemia Mieloide Aguda/enzimología , Mandíbula/diagnóstico por imagen , Mandíbula/cirugía , Neoplasias Mandibulares/complicaciones , Neoplasias Mandibulares/enzimología , Peroxidasa/análisis , Cintigrafía , Sarcoma Mieloide/complicaciones , Sarcoma Mieloide/enzimología , Trastornos de la Articulación Temporomandibular/complicaciones , Trastornos de la Articulación Temporomandibular/enzimologíaRESUMEN
PURPOSE: To describe a new glenoid fossa bone graft technique, and to evaluate its effect on the stability of stock fossa prosthesis implantation in total alloplastic joint replacement surgery. METHODS: Eight patients who underwent total joint replacement surgery with a Biomet stock prosthesis (Biomet, Warsaw, IN, USA) from November 2013 to April 2014 were included in this study. ProPlan CMF 1.4 software (Materialise NV, Leuven, Belgium) was used to choose the prosthesis size and place it in the right position. The depth of the fossa was measured, and the osteotomy line was designed to cut the bone which overlapped the fossa prosthesis. A bone graft, taken from the bottom of the articular eminence or the condylar neck, was used to fill in the fossa and make a flat plane in combination with the residual eminence for the positioning of the fossa prosthesis. The stability of the fossa prosthesis was evaluated both intra-operatively and postoperatively with computed tomography (CT) scanning after at least 6 months of follow-up. The bone contact area of the fossa prosthesis and the volume of the grafted bone were measured. RESULTS: Fossa prostheses were intra-operatively stable after bone grafting. All patients had stable occlusion after surgery and at follow-up. Postoperative measurement showed that the bone contact area with the fossa prosthesis increased from 52.8% to 88.5% after bone grafting. Postoperative CT measurements (at an average of 9 months after surgery) showed that the bone graft volume decreased by 11.1%. CONCLUSION: Bone grafts in the glenoid fossa help to improve the stability of Biomet stock fossa prosthesis implantation.
Asunto(s)
Trasplante Óseo/métodos , Prótesis Articulares , Implantación de Prótesis/métodos , Hueso Temporal/cirugía , Articulación Temporomandibular/cirugía , Adulto , Anciano , Oclusión Dental , Femenino , Estudios de Seguimiento , Humanos , Imagenología Tridimensional/métodos , Cuidados Intraoperatorios , Masculino , Persona de Mediana Edad , Osteotomía/métodos , Planificación de Atención al Paciente , Diseño de Prótesis , Retención de la Prótesis , Estudios Retrospectivos , Programas Informáticos , Cirugía Asistida por Computador/métodos , Hueso Temporal/diagnóstico por imagen , Articulación Temporomandibular/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Interfaz Usuario-ComputadorRESUMEN
OBJECTIVE: To present three modified techniques of total alloplastic temporomandibular joint replacement (TMJ TJR) and to evaluate the outcomes regarding prosthesis stability and heterotopic bone formation. MATERIAL AND METHODS: A total of 15 patients (19 joints), treated with the Biomet stock prosthesis from May 2006 to May 2013, were retrospectively analyzed. Surgical procedures were performed with the following three modifications: bone grafting of the glenoid fossa; salvage of TMJ discs; and harvesting of retro-mandibular subcutaneous fats. The glenoid fossa depth was measured preoperatively by Surgicase 5.0 software. All patients were evaluated by radiographic examination and surgical observation. RESULTS: The fossa was grafted with an autogenous bone in 15 joints (78.9%). In 4 joints (21.1%), only bone repair was performed. Radiographic evaluation revealed a good integration between the autogenous and host bones. All patients showed postoperative occlusal stability. In 5 joints (26.3%), the discs were salvaged. Both bleeding and operation time were reduced. Fat grafts were harvested in 17 joints (89.5%), in which there were no abnormalities in the periprosthetic bone structure. In 2 joints (10.5%), with no fat grafting, heterotopic bone formation was found. CONCLUSIONS: The modified techniques of TJR help to improve prostheses stability, reducing heterotopic bone formation and avoiding additional scars.
Asunto(s)
Artroplastia de Reemplazo/métodos , Articulación Temporomandibular/cirugía , Anciano , Autoinjertos/trasplante , Pérdida de Sangre Quirúrgica/prevención & control , Trasplante Óseo/métodos , Estudios de Cohortes , Femenino , Estudios de Seguimiento , Humanos , Prótesis Articulares , Masculino , Persona de Mediana Edad , Tempo Operativo , Osificación Heterotópica/prevención & control , Complicaciones Posoperatorias/prevención & control , Retención de la Prótesis , Radiografía Panorámica/métodos , Estudios Retrospectivos , Grasa Subcutánea/trasplante , Hueso Temporal/cirugía , Disco de la Articulación Temporomandibular/cirugía , Recolección de Tejidos y Órganos/métodos , Tomografía Computarizada por Rayos X/métodos , Resultado del TratamientoRESUMEN
PURPOSE: To evaluate the effect of total joint replacement in treatment of temporomandibular joint(TMJ) osteoarthropathy with stock prostheses. METHODS: Six female patients involving 10 joints (2 unilateral and 4 bilateral), with an average age of 59 years old, were involved in this study. Three patients (5 joints) were diagnosed as internal derangement in V stage depending on MRI, 3D-CT findings and clinical characteristics. The other 3 patients (5 joints) had histories of failed temporomandibular joint operation using costochondral graft or temporalis fascial flap. The maximal mouth opening was 1.9 cm on average (range, 1.0 to 2.9cm). All the joints were replaced with Biomet standard prosthesis under general anesthesia. RESULTS: The follow-up period was from 7 to 49 months (average, 17.5 months). All the operations were successfully performed. Heterotopic ossification happened in a bilateral case 1 year postoperatively. One patient with bilateral joint disease complained of severe uncomfortable feeling in the region of the ears and the temples, although there was no significant positive signs according to an ENT examination. Pain relief of the joint and mouth opening improvement were significant in 4 patients. No failure was noted secondary to infection or loosening of the prostheses. The occlusal relationship kept stable postoperatively in all cases. CONCLUSIONS: Total TMJ joint replacement with standard prosthesis is a good choice for TMJ reconstruction. It can significantly reduce joint pain and the mouth opening limitation resulted from osteoarthritis. Long-term result remains to be evaluated based on a long-term follow-up.
Asunto(s)
Rango del Movimiento Articular , Trastornos de la Articulación Temporomandibular , Artroplastia de Reemplazo , Femenino , Humanos , Prótesis Articulares , Persona de Mediana Edad , Colgajos Quirúrgicos , Articulación Temporomandibular , Resultado del TratamientoRESUMEN
INTRODUCTION: More than 200 cases of synovial chondromatosis (SC) in the TMJ were reported. Most of SC described exclusively involved the upper compartment of the joint. SC originally arising in the lower compartment is rarely found. MATERIAL AND METHODS: This article presents a 50-year-old man with a slow growing, pain, preauricular swelling in left side and the limitation of mouth-opening. Panoramic radiograph, CT scans and MR images were taken. An arthroscopic examination and a surgical intervention were performed. RESULTS: Panoramic radiograph and CT scans didn't reveal the calcifying lesions in left TMJ region. Sagittal MR images and the arthroscopic examination demonstrated distinct nodules within an extremely expanded lower joint compartment and a normal position of the articular disc. All loose bodies and grossly abnormal synovium were removed. The diagnosis of SC was confirmed by histologic examination. CONCLUSION: MRI and arthroscopy may be helpful diagnostically. Removal of all involved synovium, and loose cartilaginous bodies may be required for adequate treatment.
Asunto(s)
Condromatosis Sinovial/patología , Condromatosis Sinovial/cirugía , Trastornos de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/cirugía , Articulación Temporomandibular/patología , Artralgia/etiología , Artroscopía , Condromatosis Sinovial/complicaciones , Drenaje , Asimetría Facial/etiología , Humanos , Cuerpos Libres Articulares/etiología , Cuerpos Libres Articulares/cirugía , Imagen por Resonancia Magnética , Masculino , Cóndilo Mandibular/patología , Persona de Mediana Edad , Radiografía Panorámica , Rango del Movimiento Articular , Articulación Temporomandibular/cirugía , Tomografía Computarizada por Rayos XRESUMEN
PURPOSE: This study was aimed to set up a new method for reconstruction of maxillary defect with distraction osteogenesis through an animal experiment. METHODS: 11 adult goats were randomly divided into 2 groups (9 in the experimental group and 2 in the control group) in this study. 3 subgroups were set up in the experimental group based on the consolidation period. Other 2 goats were chosen as the control group. Maxillary defect was made firstly through partial maxillectomy for the experimental group. Length of the defects was from 12 to 14mm with an average of 12.7mm. A transport disc was then made through anterior Le Fort I osteotomy and it would be shifted backward for the closure of the defect. Only maxillary defect was made for the control group. Distraction was activated after a latency of 7 days at a rate of 0.4mm twice a day for 15-18 days. RESULTS: Bone defects in the maxilla were well repaired when the transport disc was distracted back to its original position. Radiology and histology demonstrated good new bone formation in the distraction gap. CONCLUSIONS: Transport distraction osteogenesis would be a reasonable method for reconstruction of maxillary defect.