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1.
Medicina (Kaunas) ; 60(2)2024 Feb 10.
Artículo en Inglés | MEDLINE | ID: mdl-38399593

RESUMEN

Background and Objectives: The surge in breast-related surgeries in Korea underscores the critical need for an accurate early diagnosis of silicone breast implant-related issues. Complications such as BIA-ALCL and BIA-SCC add complexity to breast health concerns, necessitating vigilant monitoring. Despite advancements, discrepancies persist between ultrasonographic and pathologic classifications of silicone implant ruptures, highlighting a need for enhanced diagnostic tools. This study explores the reliability of ultrasonography in diagnosing silicone breast implant ruptures and determining the extent of silicone migration, specifically with a focus on guiding potential capsulectomy based on pathology. Materials and Methods: A comprehensive review of medical records encompassing 5557 breast implants across 2790 patients who underwent ultrasound-assisted examinations was conducted. Among the screened implants, 8.9% (249 cases) were diagnosed with silicone breast implant rupture through ultrasonography. Subsequently, 89 women underwent revisional surgery, involving capsulectomy. The pathological analysis of 111 periprosthetic capsules from these cases aimed to assess the extent of silicone migration, and the findings were juxtaposed with the existing ultrasonographic rupture classification. Results: The diagnostic agreement between preoperative sonography and postoperative findings reached 100% for silicone breast implant ruptures. All eighty prosthetic capsules exhibiting a snowstorm sign in ultrasonography demonstrated silicone migration to capsules upon pathologic findings. Conclusions: High-resolution ultrasonography emerged as a valuable and reliable imaging modality for diagnosing silicone breast implant ruptures, with a notable ability to ascertain the extent of free silicone migration to capsules. This diagnostic precision is pivotal in informing decisions about potential capsulectomy during revisional surgery. The study advocates for an update to the current binary ultrasonographic classification, suggesting a more nuanced categorization into three types (subcapsular, intracapsular, and extracapsular) based on pathology.


Asunto(s)
Implantes de Mama , Femenino , Humanos , Implantes de Mama/efectos adversos , Siliconas/efectos adversos , Sistemas de Atención de Punto , Reproducibilidad de los Resultados , Falla de Prótesis , Ultrasonografía , Rotura , Imagen por Resonancia Magnética/métodos
3.
Langenbecks Arch Surg ; 408(1): 312, 2023 Aug 15.
Artículo en Inglés | MEDLINE | ID: mdl-37581699

RESUMEN

INTRODUCTION: In esthetic surgery, the use of silicone implants is a topic of hot discussion. MATERIAL AND METHODS: An analysis of 119 esthetic surgical interventions on the mammary gland was performed. A study of the immune and endocrine parameters after mammoplasty was carried out. RESULTS: The phenomenon of an increase in the levels of autoantibodies to the TSH receptor was revealed. The phenomenon of pre-operative growth of prolactin and TSH levels has been confirmed. An increase in thyroid autoimmunity after silicone mammoplasty is interpreted as a result of a silicone adjuvant action. An increase in the incidence of ASIA syndrome in patients who underwent breast surgery was registered. However, it was observed in both patients with silicone and non-silicone breast surgeries and therefore could not be solely explained by the use of silicone. Within 12 months following silicone mammoplasty, the patients with an increase of anti-TSH receptor autoimmunity nevertheless did not show any clinical and laboratory signs of overt thyroid disease, thus staying in a pre-nosological state. PRACTICAL RECOMMENDATIONS: Based on these results, we recommend the following for esthetic surgery: (a) all patients planned for silicone implant surgery should be examined for autoantibodies to the TSH receptor and (b) patients who have undergone breast endoprosthesis, starting 6 months after the operation, need long-term follow-up for thyroid status with mandatory testing for the level of these autoantibodies.


Asunto(s)
Autoinmunidad , Implantes de Mama , Humanos , Siliconas/efectos adversos , Implantes de Mama/efectos adversos , Glándula Tiroides , Autoanticuerpos
4.
Ophthalmic Plast Reconstr Surg ; 39(1): 81-87, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36136734

RESUMEN

PURPOSE: Exogenous silicone has been reported to migrate to anatomic sights far from an initial injection or implantation site; this phenomenon has been rarely described in the ocular adnexa, especially in the eyelids. We document 3 additional cases of distant migration of silicone implanted elsewhere in the body to the eyelids and review the prior literature on this uncommon event. METHODS: A retrospective chart review of 3 patients was conducted along with analysis of diagnostic histopathology. A comprehensive review of the literature regarding dissemination or migration of silicone to the eyelids in patients with either silicone breast implants or silicone facial filler use was performed. RESULTS: Cases of silicone migrating to the eyelids from silicone breast implants and silicone-based facial filler are outlined in Tables 1 and 2, respectively. There are 4 total reports of women with silicone breast implants, including the 2 described here, with evidence of migration of silicone to the eyelid. Similarly, 5 cases of silicone-based facial filler with resultant migration of filler to the eyelids were identified, including 2 of the cases presented in this report (1 patient had both silicone breast implants and silicone facial filler). CONCLUSION: Silicone is chemically inert, but is known to travel throughout the body, causing a resultant foreign body response in tissue that can adversely affect even the eyelids. Silicone has a relatively characteristic histologic appearance and diagnosis of silicone granuloma highlights the importance of obtaining a thorough clinical history, particularly regarding prior cosmetic injections or breast enhancement surgery. Foreign material/foreign body granuloma is important to consider in patients with deep eyelid nodules of unclear etiology.


Asunto(s)
Granuloma de Cuerpo Extraño , Siliconas , Humanos , Femenino , Siliconas/efectos adversos , Estudios Retrospectivos , Granuloma de Cuerpo Extraño/diagnóstico , Granuloma de Cuerpo Extraño/etiología , Granuloma de Cuerpo Extraño/patología , Párpados/patología , Prótesis e Implantes/efectos adversos
5.
Br J Neurosurg ; 37(5): 1016-1017, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-33119412

RESUMEN

PURPOSE: The purpose of this case report is to highlight silicone allergy as a rare cause of ventriculo-peritoneal shunt complication, often mimicking infection. MATERIALS AND METHODS: Information regarding the patient presented was obtained by review of their medical notes, both paper and electronically. A literature review was performed by searching Pubmed using the following terms; silicone allergy and shunt allergy, to identify similar publications. RESULTS: Nine publications between 1994 and 2019 formed the basis of the literature review. The primary aim was to identify clinical presentations that may help to identify silicone allergy as the cause of shunt complication. CONCLUSION: Silicone allergy is a rare cause of ventriculo-peritoneal (V-P) shunt failure and can mimic infection. This diagnosis should be consideredwith a predominantly lymphocytic CSF leucocytosis and no bacteriological evidence of a responsible organism, a peripheral eosinophilia and an intense fibrosis around a recently placed V-P shunt, as described in this case report.


Asunto(s)
Hidrocefalia , Hipersensibilidad , Humanos , Hidrocefalia/cirugía , Derivación Ventriculoperitoneal/efectos adversos , Hipersensibilidad/etiología , Hipersensibilidad/complicaciones , Tomografía Computarizada por Rayos X , Siliconas/efectos adversos
6.
Aesthet Surg J ; 43(1): 51-61, 2023 01 09.
Artículo en Inglés | MEDLINE | ID: mdl-35926836

RESUMEN

BACKGROUND: Some women with breast implants report systemic and cognitive symptoms known as breast implant illness (BII), which are very similar to those of fibromyalgia. Functional MRI (fMRI) has shown altered brain activity in fibromyalgia patients. OBJECTIVES: The aim of this pilot study was to investigate whether brain alterations could be observed in BII patients by fMRI. METHODS: Women aged 18 to 76 with silicone breast implants for cosmetic reasons were recruited through a Dutch online BII support organization (MKS) and through the Maastricht University Medical Center. Study participants comprised 12 women with BII and 12 women without symptoms. Participants completed questionnaires regarding demographic characteristics, medical history, psychosocial complaints (Four-Dimensional Symptom Questionnaire), cognitive failure (Mini-Mental State Examination), and pain intensity and pain-related disability (Chronic Pain Grade Scale). Subsequently, brain images of all participants were obtained by resting-state fMRI and diffusion tensor imaging in a 3-T MRI scanner (Siemens Medical System, Erlangen, Germany). RESULTS: Eleven BII patients and 12 healthy controls were included in the analysis. Baseline characteristics were similar in the 2 groups and the mean silicone exposure was 15 years. Patients scored significantly higher than controls on both pain intensity and disability. Patients scored worse on depression, somatization, distress, and anxiety compared with asymptomatic women. Mini-Mental State Examination scores were normal. However, the analyses of both functional connectivity and structural integrity showed no significant differences between the 2 groups. CONCLUSIONS: This pilot study showed no evidence of brain alterations in BII patients. However, patients scored significantly worse on psychosocial symptoms than controls. Psychological factors appear to play an important role in BII and should be further investigated.


Asunto(s)
Implantes de Mama , Dolor Crónico , Fibromialgia , Humanos , Femenino , Implantes de Mama/efectos adversos , Imagen por Resonancia Magnética , Fibromialgia/diagnóstico por imagen , Fibromialgia/etiología , Proyectos Piloto , Imagen de Difusión Tensora , Dolor Crónico/diagnóstico por imagen , Dolor Crónico/etiología , Neuroimagen , Siliconas/efectos adversos
7.
Orbit ; 42(4): 455-458, 2023 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-35576315

RESUMEN

Skin rejuvenation procedures have increasingly flooded the aesthetic market, one of which includes microneedling. In microneedling, multiple fine punctures of the skin are performed with a needle to induce neocollagenesis. Microneedling has increasingly been used to treat inflammatory acne, acne scarring, photodamaged skin, and even radiation dermatitis. We present a patient with a stable history of liquid injectable silicone (LIS) given 20 years prior who developed chronic periocular and facial hypersensitivity after undergoing microneedling at a medi-spa. Long-term steroids and immunosuppressants were needed for control. The patient's severe reaction and resistance to treatment highlights the potential complications of microneedling administered by a non-medical professional in the setting of prior injectable silicone.


Asunto(s)
Acné Vulgar , Técnicas Cosméticas , Hipersensibilidad Tardía , Humanos , Técnicas Cosméticas/efectos adversos , Siliconas/efectos adversos , Cicatriz/etiología , Acné Vulgar/terapia , Acné Vulgar/complicaciones , Hipersensibilidad Tardía/complicaciones , Resultado del Tratamiento
8.
Ann Chir Plast Esthet ; 68(4): 368-372, 2023 Aug.
Artículo en Francés | MEDLINE | ID: mdl-36966097

RESUMEN

Breast implant rupture is a common complication in plastic surgery, with various clinical presentations, due to silicone migration. In this article, we present the case of a patient with ruptured silicone implants, who developed siliconosis with rheumatoid polyarthritis, and evolved favourably after explantation surgery. The physiopathology of this disease, and the implication of silicone migration are still controversial, and yet to be confirmed.


Asunto(s)
Artritis , Implantes de Mama , Procedimientos de Cirugía Plástica , Humanos , Implantes de Mama/efectos adversos , Siliconas/efectos adversos , Rotura , Geles de Silicona/efectos adversos , Falla de Prótesis
9.
Laeknabladid ; 109(4): 186-191, 2023 Apr.
Artículo en Is | MEDLINE | ID: mdl-36988131

RESUMEN

For decades, breast implants have been available for breast reconstructions and breast augmentations to improve the patients' health-related quality of life. Silicone implants (SI) have been used since the middle of the last century for breast reconstruction, for example after breast cancer, for birth defects, gender confirmation procedures, or for breast augmentation. Every year, several hundred SI are performed in Iceland for these purposes, but no central register is maintained. It can be estimated that at least 1000 - 3000 women have SI in Iceland and that around 300 Icelandic patients get SI every year. This informal review article discusses the so-called ASIA syndrome, the immunological effects of silicone and the possible relationship of SI to autoimmune diseases, symptoms, and diagnosis. In the methodology, this paper does not rely on the strict conditions of systematic reviews, but the authors relied only on peer-reviewed sources through PubMed, UpToDate and Scopus. The keywords used are silicon, silicon implant, silicon particles, immune response, autoimmunity, autoinflammation, Autoimmune/inflammatory syndrome induced by aduvants, ASIA, ASIA syndrome, breast implant illness. The paper reviews known facts about the disease, its characteristics, and statistical aspects.


Asunto(s)
Enfermedades Autoinmunes , Implantes de Mama , Humanos , Femenino , Silicio/efectos adversos , Calidad de Vida , Revisiones Sistemáticas como Asunto , Implantes de Mama/efectos adversos , Enfermedades Autoinmunes/diagnóstico , Enfermedades Autoinmunes/inducido químicamente , Siliconas/efectos adversos , Síndrome
10.
Lupus ; 31(12): 1532-1535, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-36040116

RESUMEN

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld's syndrome, encompasses several autoimmune conditions/phenomena that are triggered following the exposure to materials with an adjuvant activity known to augment an antigen-driven immune response. In some inherently vulnerable patients, they act as second hits to trigger or unmask an autoimmune disorder which ranges from generalized non-specific constitutional symptoms, and autoantibody production, to a new onset, of a fully-fledged autoimmune syndrome. In this manuscript, we present a case of a 37-year-old lady who developed systemic lupus erythematosus characterized by mucocutaneous, musculoskeletal, hematological neurological, and renal involvement a few years after silicone breast implants.


Asunto(s)
Enfermedades Autoinmunes , Implantes de Mama , Lupus Eritematoso Sistémico , Adyuvantes Inmunológicos/efectos adversos , Adulto , Femenino , Humanos , Lupus Eritematoso Sistémico/complicaciones , Lupus Eritematoso Sistémico/diagnóstico , Siliconas/efectos adversos , Síndrome
11.
Artif Organs ; 46(12): 2400-2411, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35866431

RESUMEN

BACKGROUND: To determine suitable alternatives to human blood for in vitro dynamic thrombogenicity testing of biomaterials, four different animal blood sources (ovine, bovine, and porcine blood from live donors, and abattoir porcine blood) were compared to fresh human blood. METHODS: To account for blood coagulability differences between individual donors and species, each blood pool was heparinized to a donor-specific concentration immediately before testing in a dynamic flow loop system. The target heparin level was established using a static thrombosis pre-test. For dynamic testing, whole blood was recirculated at room temperature for 1 h at 200 ml/min through a flow loop containing a single test material. Four materials with varying thrombotic potentials were investigated: latex (positive control), polytetrafluoroethylene (PTFE) (negative control), silicone (intermediate thrombotic potential), and high-density polyethylene (HDPE) (historically thromboresistant). Thrombus weight and surface area coverage on the test materials were quantified, along with platelet count reduction in the blood. RESULTS: While donor-specific heparin levels varied substantially from 0.6 U/ml to 7.0 U/ml among the different blood sources, each source was able to differentiate between the thrombogenic latex and the thromboresistant PTFE and HDPE materials (p < 0.05). However, only donor ovine and bovine blood were sensitive enough to differentiate an increased response for the intermediate thrombotic silicone material compared to PTFE and HDPE. CONCLUSIONS: These results demonstrated that multiple animal blood sources (particularly donor ovine and bovine blood) may be suitable alternatives to fresh human blood for dynamic thrombogenicity testing when appropriate control materials and donor-specific anticoagulation levels are used.


Asunto(s)
Materiales Biocompatibles , Trombosis , Animales , Bovinos , Humanos , Materiales Biocompatibles/efectos adversos , Heparina/sangre , Látex/efectos adversos , Ensayo de Materiales/métodos , Polietileno/efectos adversos , Politetrafluoroetileno/efectos adversos , Ovinos , Siliconas/efectos adversos , Trombosis/etiología
12.
Am J Dermatopathol ; 44(6): 454-455, 2022 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-35220327

RESUMEN

ABSTRACT: Different adverse reactions to silicone present in cosmetic fillers, implants, or medical devices have been reported. The granulomatous reaction on the injection site due to catheters' silicone coating is an infrequent complication, which may be clinically difficult to suspect. Although the definitive diagnosis requires identification of the silicone with techniques such as X-ray spectroscopy, the possibility of involvement of silicone, as well as the histopathologic demonstration of granulomas with refractile, nonpolarizable, and nonstainable material strongly suggests this diagnosis. Moreover, the use of a low-diaphragm aperture or phase-contrast microscopy could be useful to demonstrate the presence of this, otherwise almost transparent, foreign body.


Asunto(s)
Técnicas Cosméticas , Granuloma de Cuerpo Extraño , Cánula/efectos adversos , Técnicas Cosméticas/efectos adversos , Granuloma de Cuerpo Extraño/etiología , Granuloma de Cuerpo Extraño/patología , Humanos , Punciones/efectos adversos , Siliconas/efectos adversos
13.
Ophthalmic Plast Reconstr Surg ; 38(6): e170-e173, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35699211

RESUMEN

Orbital implant extrusion is a known complication following evisceration and enucleation. In this case report, we present a 45-year-old woman who presented with a left silicone implant exposure and infection 2 years following evisceration with saddle nose on examination. CT of the maxillofacial bones without contrast showed bilateral soft tissue infiltration around the superior recti muscles, as well as a nasal septum perforation from extensive sinus disease. Left orbitotomy revealed a small fibrotic mass near the orbital roof. Biopsy and serology results were consistent with granulomatosis with polyangiitis.


Asunto(s)
Anoftalmos , Granulomatosis con Poliangitis , Implantes Orbitales , Femenino , Humanos , Persona de Mediana Edad , Enucleación del Ojo , Granulomatosis con Poliangitis/complicaciones , Granulomatosis con Poliangitis/diagnóstico , Implantes Orbitales/efectos adversos , Siliconas/efectos adversos , Evisceración del Ojo
14.
J Craniofac Surg ; 33(6): e552-e553, 2022 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-34907948

RESUMEN

ABSTRACT: Rhinoplasty via a closed approach is rarely performed due to provide limited exposure and inadequate operative field. Nevertheless, there are some cases in which closed approach is performed using L-shaped silicone implants. The authors recently encountered an interesting complication in a 33-year-old woman who had previously undergone rhinoplasty via a closed approach and who sought revision rhinoplasty at our institution. The authors accidently found a fractured silicone implant on lateral nasal x-ray. She had no nasal trauma history since previous rhinoplasty. The authors assumed that the silicone implant can be fractured as 1 of complications during the rhinoplasty via a closed approach.


Asunto(s)
Implantes Dentales , Fracturas Óseas , Rinoplastia , Adulto , Femenino , Humanos , Prótesis e Implantes , Reoperación , Rinoplastia/efectos adversos , Siliconas/efectos adversos
15.
Women Health ; 62(4): 302-314, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-35575123

RESUMEN

To evaluate the current state of the evidence regarding the association of silicone breast implantation with the onset of connective tissue diseases, constitutional symptoms, and rheumatic serological profile in adult women. A comprehensive search was carried out using MEDLINE, Embase, Web of Science and Scopus, from inception to September 2, 2020. Cohort studies assessing the clinical and serological profile of women with cosmetic breast implants were included. Meta-analyses were conducted using risk ratios. A total of 10 cohorts with overall moderate quality of evidence were included in this systematic review. Exposure to silicone breast implants was slightly associated with the development of rheumatoid arthritis [RR: 1.35; (95% CI 1.08 to 1.68); P = .008; I2 = 0%]. However, no significant differences were exhibited between the breast implant-exposed population and controls regarding the rest of the outcomes. In adult women, exposure to silicone breast implantation is not associated with the onset of constitutional symptoms and most connective tissue diseases. A marginal association with rheumatoid arthritis was exhibited, but the certainty of this result is jeopardized by the significant amount of self-reported data for this outcome. Further research is required to adequately explore the clinical significance of these results.


Asunto(s)
Artritis Reumatoide , Implantes de Mama , Enfermedades del Tejido Conjuntivo , Adulto , Artritis Reumatoide/epidemiología , Artritis Reumatoide/etiología , Implantes de Mama/efectos adversos , Enfermedades del Tejido Conjuntivo/diagnóstico , Enfermedades del Tejido Conjuntivo/epidemiología , Enfermedades del Tejido Conjuntivo/etiología , Consenso , Femenino , Humanos , Siliconas/efectos adversos
16.
Harefuah ; 161(6): 371-377, 2022 Jun.
Artículo en Hebreo | MEDLINE | ID: mdl-35734794

RESUMEN

INTRODUCTION: This article will review the complications of contact lenses (CL) according to the literature over the past few years including mechanical, inflammatory, allergic, toxic, metabolic, and infectious complications. There are CL complications that are not sight-threatening and there are severe complications that do threaten the sight. In general, any complication from CL that involves the cornea may endorse irreversible damage to sight. Most of the complications that involve the cornea are complications due to infectious backgrounds and are the most severe amongst CL wearers. The more continuous the CL wear is, the greater the danger to develop a complication. In the past it was assumed that switching from hydrogel CL to silicone hydrogel CL would reduce the incidence of CL complications, but this was not the case. From the point of view of wearing habits, the use of reusable CL (weekly or monthly) produced from more advanced raw materials did not reduce the percentage of complications. The complication may be due to incorrect CL compliance, incorrect use of the disinfecting solutions, incorrect compliance and cleaning of the CL. CL wearers aged between 15 to 19 years are the largest risk group to develop complications. Amongst younger aged wearers there is more precision due to parent supervision. The purchase of CL on-line has increased the percentage of complications because the patient purchasing the CL on-line does not attribute importance to the periodic examination by the professional eye therapist.


Asunto(s)
Lentes de Contacto , Adolescente , Adulto , Lentes de Contacto/efectos adversos , Humanos , Hidrogeles , Incidencia , Factores de Riesgo , Siliconas/efectos adversos , Adulto Joven
17.
J Autoimmun ; 120: 102631, 2021 06.
Artículo en Inglés | MEDLINE | ID: mdl-33799099

RESUMEN

IMPORTANCE AND OBJECTIVES: There is unmet medical need to understand the pathogenic mechanism of the panoply of clinical manifestations associated with silicone breast implants (SBIs) such as severe fatigue, widespread pain, palpitations, dry mouth and eyes, depression, hearing loss etc. We aimed to determine whether autoantibodies against the autonomic nervous system receptors can explain the enigmatic and subjective clinical manifestation reported by women with SBIs. RESULTS: Circulating level of autoantibodies against G protein-coupled receptors (GPCRs) of the autonomic nervous system (adrenergic, muscarinic, endothelin and angiotensin receptors) have been evaluated in symptomatic women with SBIs using an ELISA method. These women with SBIs addressed our clinic due to various subjective and autonomic-related manifestations such as chronic severe fatigue, cognitive impairment, widespread pain, memory loss, sleep disorders, palpitations, depression, hearing abnormalities etc. We report for the first time, a significant reduction in the sera level of anti-ß1 adrenergic receptor (p < 0.001), anti-angiotensin II type 1 receptor (p < 0.001) and anti-endothelin receptor type A (p = 0.001) autoantibodies in women with SBIs (n = 93) as compared with aged matched healthy women (n = 36). Importantly, anti-ß1 adrenergic receptor autoantibody was found to significantly correlate with autonomic-related manifestations such as: sleep disorders and depression in women with SBIs. CONCLUSIONS: Chronic immune stimulation by silicone material may lead to an autoimmune dysautonomia in a subgroup of potentially genetically susceptible women with SBIs. The appearance of autoantibodies against GPCRs of the autonomic nervous system serve as an explanation for the subjective autonomic-related manifestations reported in women with SBIs.


Asunto(s)
Enfermedades Autoinmunes/diagnóstico , Enfermedades Autoinmunes/etiología , Implantes de Mama/efectos adversos , Disautonomías Primarias/diagnóstico , Disautonomías Primarias/etiología , Siliconas/efectos adversos , Autoanticuerpos/sangre , Autoanticuerpos/inmunología , Autoantígenos/inmunología , Biomarcadores , Estudios de Casos y Controles , Manejo de la Enfermedad , Susceptibilidad a Enfermedades , Femenino , Humanos , Receptores Adrenérgicos beta 1/inmunología , Receptores Acoplados a Proteínas G/inmunología
18.
Dis Colon Rectum ; 64(4): 466-474, 2021 04 01.
Artículo en Inglés | MEDLINE | ID: mdl-33399411

RESUMEN

BACKGROUND: Anal inserts and percutaneous tibial nerve stimulation may be offered to those with fecal incontinence in whom other conservative treatments have failed. OBJECTIVE: We aimed to compare anal inserts and percutaneous tibial nerve stimulation. DESIGN: This was an investigator-blinded randomized pilot study. SETTINGS: The study was conducted at a large tertiary care hospital. PATIENTS: Adult patients with passive or mixed fecal incontinence were recruited. INTERVENTIONS: Patients were randomly assigned to receive either the anal inserts or weekly percutaneous tibial nerve stimulation for a period of 3 months. MAIN OUTCOME MEASURES: The primary end point was a 50% reduction of episodes of fecal incontinence per week as calculated by a prospectively completed 2-week bowel diary. Secondary end points were St Mark's incontinence score, International Consultation on Incontinence Questionnaire-Bowel scores (for bowel pattern, bowel control, and quality of life), use of antidiarrheal agents, estimates of comfort and acceptability. RESULTS: Fifty patients were recruited: 25 were randomly assigned to anal inserts and 25 were randomly assigned to percutaneous tibial nerve stimulation. All completed treatment. A significant improvement of scores in the 2-week bowel diary, the St Mark's scores and the International Consultation on Incontinence Questionnaire-Bowel scores, was seen in both groups after 3 months of treatment. A reduction of ≥50% fecal incontinence episodes was reached by 76% (n = 19/25) by the anal insert group, compared with 48% (n = 12/25) of those in the percutaneous tibial nerve stimulation group (p = 0.04). The St Mark's fecal incontinence scores and the International Consultation on Incontinence Questionnaire-Bowel scores for bowel pattern, bowel control, and quality of life (p = 0.01) suggest similar improvement for each group. LIMITATIONS: A realistic sample size calculation could not be performed because of the paucity of objective prospective studies assessing the effect of the insert device and percutaneous tibial nerve stimulation. CONCLUSIONS: Both anal insert and percutaneous tibial nerve stimulation improved the symptoms of fecal incontinence after 3 months of treatment. The insert device appeared to be more effective than percutaneous tibial nerve stimulation. Larger studies are needed to investigate this further. See Video Abstract at http://links.lww.com/DCR/B460. TRIAL REGISTRATION NUMBER: Clinicaltrials.gov No. NCT04273009. ESTUDIO PILOTO ALEATORIZADO DE INSERCIONES ANALES CONTRA LA ESTIMULACIN PERCUTNEA DEL NERVIO TIBIAL EN PACIENTES CON INCONTINENCIA FECAL: ANTECEDENTES:Las inserciones anales y la estimulación percutánea del nervio tibial (PTNS) se pueden ofrecer a las personas con incontinencia fecal que han fallado en otros tratamientos conservadores.OBJETIVO:Nuestro objetivo fue comparar inserciones anales y estimulación percutánea del nervio tibial.DISEÑO:Este fue un estudio piloto aleatorio ciego para investigadores.AJUSTE:El estudio se realizó en un hospital de atención terciaria.PACIENTES:Se reclutaron pacientes adultos con incontinencia fecal pasiva o mixta.INTERVENCIONES:Los pacientes fueron asignados al azar para recibir inserciones anales o estimulación del nervio tibial percutáneo semanal durante un período de tres meses.PRINCIPALES MEDIDAS DE RESULTADO:El principal resultado fue una reducción del 50% de los episodios de incontinencia fecal por semana, según lo calculado mediante un diario intestinal de dos semanas completado de forma prospectiva. Los criterios de valoración secundarios fueron la puntuación de incontinencia de St Mark, las puntuaciones del ICIQ-B (para patrón intestinal, control intestinal y calidad de vida), uso de agentes antidiarreicos, estimaciones de comodidad y aceptabilidad.RESULTADOS:Se reclutaron 50 pacientes: 25 fueron asignados al azar a inserciones anales y 25 a PTNS. Todo el tratamiento completado. Se observó una mejora significativa de las puntuaciones en el diario intestinal de dos semanas, la puntuación de St Mark y la puntuación del ICIQ-B en ambos grupos después de 3 meses de tratamiento. Se alcanzó una reducción de ≥ 50% de los episodios de incontinencia fecal en un 76% (n = 19/25) en el grupo de inserción anal, en comparación con el 48% (n = 12/25) de los del grupo de estimulación percutánea del nervio tibial (p = 0,04). Las puntuaciones de incontinencia fecal de St Mark, las puntuaciones del ICIQ-B para el patrón intestinal, el control intestinal y la calidad de vida (p = 0,01) sugieren una mejora similar para cada grupo.LIMITACIONES:No se pudo realizar un cálculo realista del tamaño de la muestra debido a la escasez de estudios prospectivos objetivos que evaluaran el efecto del dispositivo de inserción y la estimulación percutánea del nervio tibial.CONCLUSIONES:Tanto la inserción anal como la estimulación percutánea del nervio tibial mejoraron los síntomas de incontinencia fecal después de 3 meses de tratamiento. El dispositivo de inserción parecia ser más efectivo que la estimulación percutánea del nervio tibial. Se necesitan estudios más amplios para investigar esto más a fondo. Consulte Video Resumen en http://links.lww.com/DCR/B460.NÚMERO DE REGISTRO DE PRUEBA:Clinicaltrials.gov No. NCT04273009.


Asunto(s)
Incontinencia Fecal/prevención & control , Implantación de Prótesis/instrumentación , Nervio Tibial/fisiología , Estimulación Eléctrica Transcutánea del Nervio/métodos , Adulto , Anciano , Estudios de Casos y Controles , Incontinencia Fecal/terapia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Prótesis e Implantes/efectos adversos , Prótesis e Implantes/estadística & datos numéricos , Diseño de Prótesis/tendencias , Implantación de Prótesis/métodos , Implantación de Prótesis/estadística & datos numéricos , Calidad de Vida , Siliconas/efectos adversos , Encuestas y Cuestionarios , Estimulación Eléctrica Transcutánea del Nervio/estadística & datos numéricos , Resultado del Tratamiento
19.
J Clin Ultrasound ; 49(6): 610-613, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-33782976

RESUMEN

Silicone-induced lymphadenopathy is a rare complication associated with silicone breast implants. It is usually asymptomatic and found incidentally during imaging. We report a case of silicone lymphadenopathy in a patient who had undergone a mastectomy and breast reconstruction for breast cancer. During follow-up, a positron emission tomography-computed tomography examination revealed lymph nodes that were suspicious for cancer recurrence. However, sonography was able to correctly diagnose silicone-induced lymphadenopathy and exclude cancer metastasis.


Asunto(s)
Neoplasias de la Mama/diagnóstico , Linfadenopatía/inducido químicamente , Linfadenopatía/diagnóstico por imagen , Tomografía Computarizada por Tomografía de Emisión de Positrones , Siliconas/efectos adversos , Implantes de Mama/efectos adversos , Diagnóstico Diferencial , Humanos , Linfadenopatía/patología , Persona de Mediana Edad , Recurrencia , Ultrasonografía
20.
Arch Orthop Trauma Surg ; 141(1): 173-181, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33159549

RESUMEN

INTRODUCTION: The aim was to analyse complications after surface replacing and silicone proximal interphalangeal (PIP) joint arthroplasty. MATERIALS AND METHODS: All complications, reoperations (subsequent intervention without implant modification) and revisions (subsequent surgery with implant modification or removal) were extracted out of our registry for two cohorts: (1) Patients who received a surface replacing arthroplasty at the PIP joint using the CapFlex-PIP prosthesis and (2) patients who received a PIP silicone implant. Furthermore, radiographs were evaluated for deviations from the longitudinal finger axis. RESULTS: In our registry, 279 surface replacing implants and 424 silicone implants have been documented. The overall complication rate was 20% for surface replacements and 11% for silicone arthroplasties (p ≤ 0.01) with soft tissue-related events being the most prevalent in both groups. Reoperations were significantly more frequent after surface replacement (5.4%) than silicone arthroplasty (0.5%; p ≤ 0.001), while the revision rates did not differ significantly (4.4% and 3.3%, respectively; p = 0.542). Postoperative axis deviations were significantly less frequent in the surface replacement group (19% versus 58% for silicone arthroplasty; p ≤ 0.001). CONCLUSION: We recommend using a surface replacing implant in fingers with preoperative axis deviations and correctable anatomical situation, bearing in mind the higher risk of a second surgery. However, treatment outcomes also need to be considered before choosing one implant over another.


Asunto(s)
Artroplastia para la Sustitución de Dedos , Articulaciones de los Dedos/cirugía , Prótesis Articulares/efectos adversos , Complicaciones Posoperatorias , Siliconas/efectos adversos , Artroplastia para la Sustitución de Dedos/efectos adversos , Artroplastia para la Sustitución de Dedos/instrumentación , Artroplastia para la Sustitución de Dedos/métodos , Humanos , Reoperación , Resultado del Tratamiento
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