Complications and Outcomes Associated With a Novel, Prefabricated, Articulating Spacer for Two-Stage Periprosthetic Joint Infection Treatment.

BACKGROUND: Various prefabricated articulating spacer options have been described for 2-stage treatment of chronic periprosthetic joint infection, but their results are poorly generalizable between designs due to differing antibiotic and material properties. This study reports outcomes for a novel, prefabricated, commercially available cement-on-cement articulating spacer. METHODS: A retrospective review of prospectively collected data for patients undergoing treatment with a prefabricated articulating cement spacer was performed. Outcomes were categorized as spacer complications, reimplantation rates, function, reinfection, and mortality. RESULTS: Seventy-six knees and 28 hips were analyzed. Spacer survival free of fracture, instability, or other implant-related complication until reimplantation was 100%. There were no bony or spacer fractures during the interstage or reimplantation. Reimplantation occurred in 84.6% of resected joints. Following spacer implantation, all but 1 patient was allowed to bear weight. The proportion of patients requiring an assistive device decreased from 67% prior to resection to 31% following reimplantation. Knee flexion improved from an average of 88.1° before resection to 111.9° following reimplantation. Eighty-seven percent of cases were infection free at mean follow-up of 16.6 ± 10.4 months. CONCLUSION: Study results demonstrate that this novel, prefabricated, articulating antibiotic spacer is safe, allows for good interstage function, and results in reasonable infection eradication rates at early term follow-up. LEVEL OF EVIDENCE: Therapeutic Level III.

Extensor Mechanism Reconstruction Using Marlex Mesh: Is Postoperative Casting Mandatory?

BACKGROUND: Extensor mechanism (EM) disruption after total knee arthroplasty is a catastrophic complication. Reconstruction using monofilament polypropylene mesh (Marlex Mesh; CR Bard, Franklin Lakes, NJ) has emerged as the preferred treatment, but reports are limited to the designing institution. This study describes a nondesigner experience and compares 2 postoperative immobilization strategies: long leg cast vs knee immobilizer. METHODS: A retrospective review of consecutive EM reconstructions between 2012 and 2019 was performed. Primary repairs and allograft reconstructions were excluded, leaving 33 knees (30 patients) who underwent Marlex reconstruction. Mean time from disruption to reconstruction was 14 months, and 14 of 33 (42%) had previous repair or reconstruction attempts. The mean age was 69 years, and mean body mass index was 35 kg/m2. Postoperatively, extension was maintained using a knee immobilizer in 19 of 33 (58%) patients, whereas 14 of 33 (42%) patients were long leg casted. Kaplan-Meier analysis determined all-cause survivorship free of mesh failure. RESULTS: At mean 25-month follow-up, 19 of 33 (58%) EM reconstructions were functioning. Excluding explanted infections (5 recurrent and 2 new), 19 of 26 (73%) EM reconstructions were in situ. Six-year survivorship was 69% and not influenced by immobilization type (cast: 67%, immobilizer: 71%; P = .74). Extensor lag was not associated with immobilization type, improving from a mean preoperative lag of 43° to a mean postoperative lag of 9°. Among successes, University of California at Los Angeles activity and Knee Injury and Osteoarthritis Outcome Score - Joint Replacement score improvements exceeded minimal clinically important difference (2.2-3.3 and 52.5-64.0, respectively). CONCLUSION: Marlex mesh EM reconstruction is a durable and reliable treatment with acceptable clinical results achievable outside the designer institution. Provided sufficient duration and compliance with postoperative immobilization, similar outcomes can be obtained with either a cast immobilizer or a knee immobilizer.

Enhanced Biomechanical Performance of a Modern Polyester Surgical Mesh for Extensor Mechanism Reconstruction in Total Knee Arthroplasty.

BACKGROUND: Extensor mechanism (EM) disruption following total knee arthroplasty is a devastating postoperative complication. Reconstruction with a synthetic mesh is one treatment option, although the optimal mesh material remains unknown. This study sought to compare the mechanical properties of 2 mesh material types that can be used for EM reconstruction. METHODS: Mechanical properties of a polypropylene mesh (Marlex mesh) and Ligament Advanced Reinforcement System (LARS) mesh were compared using force-displacement data from a material testing machine simulating knee movement during normal human gait. Tension to failure/ultimate tensile load, stiffness coefficients, axial strain, and cyclic hysteresis testing were measured and calculated. RESULTS: Compared to polypropylene mesh, LARS mesh demonstrated a significantly higher mean ultimate tensile load (2223 N vs 1245 N, P = .002) and stiffness coefficient (255 N/mm vs 14 N/mm, P = .035) in tension to failure testing, and significantly more energy dissipation (hysteresis) in hysteresis testing (771 kJ vs 23 kJ; P ≤ .040). LARS mesh also demonstrated significantly less maximum displacement compared to the polypropylene mesh (9.2 mm vs 90.4 mm; P ≤ .001). CONCLUSION: Compared to polypropylene mesh, LARS mesh showed superior performance related to force-displacement testing. The enhanced mechanical performance of LARS mesh may correlate clinically to fewer failures, increased longevity, and higher resistance to plastic deformation (extensor lag). Future research should evaluate survivorship and clinical outcomes of these meshes when used for EM reconstruction.

No Difference in Force Required for Intraprosthetic Dislocation of Mixed Manufacturer vs Same Manufacturer Dual Mobility Articulations.

BACKGROUND: To avoid the morbidity of removing well-fixed implants during revision surgery, the off-label practice of mixing femoral heads with dual mobility (DM) polyethylene liners from different manufacturers is commonly performed. The resistance to intraprosthetic dislocation, when the inner prosthetic head disengages from the polyethylene bearing, between mixed and same manufacturer constructs remains unknown. METHODS: Between January 2010 and July 2018, 168 DM liners were retrieved. Specimens were excluded for catastrophic wear (n = 14), previously levered-out (n = 17), and cases in legal proceedings (n = 8). Using a validated setup, 129 specimens were uniaxially loaded 100 mm from the femoral head until lever-out failure of the head from the liner. The difference in maximum lever-out force (LOF) was compared for same and mixed manufacturer retrievals (Student t-test). Multivariable regression analysis evaluated the influence of potential confounders (length of implantation, head size, head material, presence of skirt) on LOF. RESULTS: Ninety-seven same and 32 mixed manufacturer DM constructs were tested. The average LOF for same (272.6 ± 68.7 N) and mixed (299.2 ± 89.0 N) manufacturer specimens was not significantly different (P = .08). An inner head size of 22.2 mm was associated with 184.4-N increase in LOF (P < .001), the presence of a skirt was associated with 63.8-N increase in maximum LOF, and head material (ceramic vs metal) did not influence LOF. CONCLUSION: We found no difference in the force required to lever-out same and mixed manufacturer inner heads from DM liners, suggesting that mixing manufacturers when placing DM articulations on well-fixed femoral stems should not increase the risk of intraprosthetic instability.

The preoperative prediction of success following irrigation and debridement with polyethylene exchange for hip and knee prosthetic joint infections.

Although the criterion standard for the treatment of prosthetic joint infections (PJIs) is 2-stage revision with interim placement of an antibiotic-loaded spacer, irrigation and debridement with polyethylene exchange offer advantages such as fewer surgeries, reduced potential for intraoperative complications, and lower direct costs. The purpose of this study was to develop a tool to preoperatively predict the probability of successful infection eradication following irrigation and debridement with polyethylene exchange for hip or knee PJIs. A total of 10,411 surgical cases were retrospectively reviewed, and data were collected from 309 charts. Overall, 149 (48.2%) cases failed to eradicate the infection following irrigation and debridement with polyethylene exchange. Univariate analysis identified multiple variables independently associated with reinfection including duration of symptoms, preoperative inflammatory markers, and infecting organism. Logistic regression was used to generate a model (bootstrap-corrected concordance index of 0.645) to predict successful eradication of the infection, which was the basis for a nomogram. Using commonly obtained preoperative variables, the nomogram can be used to predict the probability of infection-free survival at 1, 2, 3, 4, and 5 years. Preoperative knowledge of the probability that a treatment strategy will eradicate a patient's PJI may improve risk assessment.