Reactive template synthesis of polypyrrole nanotubes for fabricating metal/conducting polymer nanocomposites.

Unique nanocomposites of polypyrrole/Au and polypyrrole/Pt hybrid nanotubes are synthesized employing polypyrrole (PPy) nanotubes as an advanced support by solution reduction. The conducting polymer PPy nanotubes are fabricated by using pre-prepared MnO2 nanowires as the reactive templates. MnO2 nanowires induce the 1D polymerization of pyrrole monomers and the simultaneous dissolution of the templates affords the hollow tube-like structure. The loading content of metal nanoparticles in the nanocomposites could be adjusted by simply changing the amount of metal precursors. This work provides an efficient approach to fabricate an important kind of metal/conducting polymer hybrid nanotubes that are potentially useful for electrocatalyst and sensor materials.

X-ray-Triggered CO Release Based on GdW10/MnBr(CO)5 Nanomicelles for Synergistic Radiotherapy and Gas Therapy.

Carbon monoxide (CO) therapy has become a hot topic in the field of gas therapy because of its application prospect in the treatment of various diseases. Due to the high affinity for human hemoglobin, the main challenge of CO-loaded nanomedicine is the lack of selectivity and toxicity in the delivery process. Although many commercial CO-releasing molecules (CORMs) have been widely developed because of their ability to deliver CO, CORMs still have some disadvantages, including difficult on-demand controlled CO release, poor solubility, and potential toxicity, which are limiting their further application. Herein, an X-ray-triggered CO-releasing nanomicelle system (GW/MnCO@PLGA) based on GdW10 nanoparticles (NPs) (GW) and MnBr(CO)5 (MnCO) encapsulating in the poly(lactic-co-glycolic acid) (PLGA) polymer was constructed for synergistic CO radiotherapy (RT). The production of strongly oxidative superoxide anion (O2-•) active species can lead to cell apoptosis under the X-ray sensitization of GW. Moreover, strongly oxidative O2-• radicals further oxidize and compete with the Mn center, resulting in the on-demand release of CO. The radio/gas therapy synergy to enhance the efficient tumor inhibition of the nanomicelles was investigated in vivo and in vitro. Therefore, the establishment of an X-ray-triggered controlled CO release system has great application potential for further synergistic RT CO therapy in deep tumor sites.

Engineering anatase hierarchically cactus-like TiO2 arrays for photoelectrochemical and visualized sensing platform.

This work described that one-step synthesis three dimensional anatase hierarchically cactus-like TiO2 arrays (AHCT) and their application in constructing a novel photoelectrochemical (PEC) and visualized sensing platform based on molecular imprinting technique, which reports its result with the prussian blue (PB) electrode served as the electrochromic indicator for the detection of glycoprotein (RNase B). The AHCT arrays were perpendicularly grown on FTO substrate with tunable sizes, offering many advantages, such as large contact area, rapid charge electron separation and transport. A possible formation process of the interesting AHCT arrays has been investigated based on time-dependent experiment. In addition, the PEC and visualized sensing platform was constructed based on the molecularly imprinted polymer modified AHCT arrays. Specifically, in the proposed system, the more RNase B being, the more insulating layer was formed on the surface of AHCT arrays that impeded the harvesting of light and electron transfer, resulting in the reduction of photocurrent. When upon light illumination, the photogenerated electrons flow through an external circuit to PB, leading to the reduction of PB to prussian white (PW), which is transparent. The rate of decolourization of PB is proportional to the concentration of RNase B. In this way, a visualized PEC sensing platform that gives its quantitative information could be performed by monitoring the change of color intensity. Under optimal conditions, the protocol possessed a detection range of 0.5pM to 2µM (r=0.997) and the limit of detection was 0.12 pM toward RNase B. Our method eliminates the need for sophisticated instruments and high detection expenses, making it possible to be a reliable alternative in resource-constrained regions.