Normal and shear forces between boundary sphingomyelin layers under aqueous conditions.

Sphingomyelin is one of the predominant phospholipid groups in synovial joints, where lipids have been strongly implicated in the boundary lubrication of articular cartilage; however, little attention has been paid to its lubrication behavior. In this study, we demonstrate that sphingomyelin is an excellent boundary lubricant by measuring the normal and shear forces between sphingomyelin-layer-coated surfaces with a surface force balance under aqueous conditions. Slightly negatively-charged egg sphingomyelin vesicles were adsorbed on mica either by calcium bridging or by charge screening with high concentration monovalent salt. The normal force profiles between opposing egg sphingomyelin layers (vesicles or bilayers) show long-ranged weak repulsion and short-ranged strong repulsion on approaching. Friction coefficients, calculated from the highest load, were (7.2 ± 1.7) × 10-4 at contact stresses of 9.1 ± 0.7 MPa across 0.3 mM liposome dispersion in 0.03 mM Ca2+, and (0.8-3.5) × 10-3 at contact stresses of 7.6 ± 0.8 MPa across 0.3 mM liposome dispersion in 150 mM NaNO3. Similar or slightly lower friction coefficients of (5.3 ± 0.8) × 10-4 at 9.8 ± 0.2 MPa were obtained by replacing the liposome dispersion in 0.03 mM Ca2+ by water. Such low friction coefficients, attributed to the hydration lubrication mechanism, are comparable to those of phosphatidylcholine lipids, which have been widely recognized as excellent aqueous biolubricants. Therefore, we believe that sphingomyelin, in parallel with phosphatidylcholine, contributes to the remarkably good boundary lubrication in synovial joints.

Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective.

Oral cancer (OC), characterized by malignant tumors in the mouth, is one of the most prevalent malignancies worldwide. Chemotherapy is a commonly used treatment for OC; however, it often leads to severe side effects on human bodies. In recent years, nanotechnology has emerged as a promising solution for managing OC using nanomaterials and nanoparticles (NPs). Nano-drug delivery systems (nano-DDSs) that employ various NPs as nanocarriers have been extensively developed to enhance current OC therapies by achieving controlled drug release and targeted drug delivery. Through searching and analyzing relevant research literature, it was found that certain nano-DDSs can improve the therapeutic effect of drugs by enhancing drug accumulation in tumor tissues. Furthermore, they can achieve targeted delivery and controlled release of drugs through adjustments in particle size, surface functionalization, and drug encapsulation technology of nano-DDSs. The application of nano-DDSs provides a new tool and strategy for OC therapy, offering personalized treatment options for OC patients by enhancing drug delivery, reducing toxic side effects, and improving therapeutic outcomes. However, the use of nano-DDSs in OC therapy still faces challenges such as toxicity, precise targeting, biodegradability, and satisfying drug-release kinetics. Overall, this review evaluates the potential and limitations of different nano-DDSs in OC therapy, focusing on their components, mechanisms of action, and laboratory therapeutic effects, aiming to provide insights into understanding, designing, and developing more effective and safer nano-DDSs. Future studies should focus on addressing these issues to further advance the application and development of nano-DDSs in OC therapy.

Stepwise Energy Transfer: Near-Infrared Persistent Luminescence from Doped Polymeric Systems.

Organic near infrared (NIR) persistent-luminescence systems with bright and long-lived emission are highly valuable for applications in communication, imaging, and sensors. However, realizing these materials (especially lifetime over 0.1 s) is a challenge, mainly because of non-radiative quenching of their long-lived excitons. Herein, a universal strategy of stepwise Förster resonance energy transfer (FRET) for a bright NIR system with remarkable persistent luminescence (up to 0.2 s at 810 nm) is presented, based on a new triphenylene-dye-doped polymer (triphenylene-2-ylboronic acid@poly(vinyl alcohol) (TP@PVA)) with a persistent blue phosphorescence of 3.29 s. This persistent NIR luminescence is demonstrated for application not only in NIR anti-counterfeiting but also NIR bioimaging with penetrating a piece of skin as thick as 2.0 mm. By co-doping a red dye (such as Nile red) and an NIR dye Cyanine 7 (Cy7) into this doped PVA film, the shortage of spectral overlap between TP emission and Cy7 absorbance is successfully solved, through a stepwise FRET process involving triplet to singlet (TS)-FRET from TP to the intermediate red dye and then singlet to singlet (SS)-FRET to Cy7. It is noted that the efficiency of the upper TS-FRET is enhanced significantly by the lower SS-FRET, leading to high efficiencies for the continuous FRETs.

Nanocellulose, a tiny fiber with huge applications.

Nanocellulose is of increasing interest for a range of applications relevant to the fields of material science and biomedical engineering due to its renewable nature, anisotropic shape, excellent mechanical properties, good biocompatibility, tailorable surface chemistry, and interesting optical properties. We discuss the main areas of nanocellulose research: photonics, films and foams, surface modifications, nanocomposites, and medical devices. These tiny nanocellulose fibers have huge potential in many applications, from flexible optoelectronics to scaffolds for tissue regeneration. We hope to impart the readers with some of the excitement that currently surrounds nanocellulose research, which arises from the green nature of the particles, their fascinating physical and chemical properties, and the diversity of applications that can be impacted by this material.