1.
ACS Comb Sci
; 14(8): 460-4, 2012 Aug 13.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22746181
RESUMO
An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally friendly manner.