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1.
Zhongguo Dang Dai Er Ke Za Zhi ; 24(4): 366-371, 2022 Apr 15.
Artigo em Zh | MEDLINE | ID: mdl-35527409

RESUMO

OBJECTIVES: To investigate the influencing factors for the quality of bowel preparation before colonoscopy in children and the association of the interval from the last administration of laxative to the start of colonoscopy (shortly referred to as waiting time) with the quality of bowel preparation. METHODS: A retrospective analysis was performed for the children who were admitted to the Department of Gastroenterology, Children's Hospital of Nanjing Medical University, from January to November 2020, and received bowel preparation with polyethylene glycol electrolyte powder combined with diet control before colonoscopy. According to the score of Boston bowel preparation scale, they were divided into two groups: adequate bowel preparation group (n=337) and inadequate bowel preparation group (n=30). Related data were collected from the children in both groups, including general information, possible influencing factors for the quality of bowel preparation, adverse reactions associated with bowel preparation, duration of colonoscopy, and postoperative diagnosis. Univariate and multivariate analyses were used to explore the influencing factors for the quality of bowel preparation. RESULTS: The univariate analysis showed that age, body weight, and waiting time were associated with inadequate bowel preparation (P<0.05). The multivariate analysis showed that older age (OR=2.155, 95%CI: 1.087-4.273, P=0.028) and longer waiting time (OR=1.559, 95% CI: 1.191-2.041, P=0.001) were independent risk factors for inadequate bowel preparation. The receiver operating characteristic (ROC) curve analysis showed that the cut-off value of waiting time was 5.5 hours in determining whether bowel preparation was adequate or not, with a sensitivity of 90.0%, a specificity of 50.7%, and an area under the ROC curve of 0.708. After grouping based on waiting time, it was found that the incidence rate of inadequate bowel preparation in the ≥5.5 hours group was significantly higher than that in the <5.5 hours group [14.0% (27/193) vs 1.7% (3/174), P<0.001]. CONCLUSIONS: For children who use polyethylene glycol electrolyte powder combined with diet control for bowel preparation, older age is an independent risk factor for inadequate bowel preparation before colonoscopy, which may be associated with an insufficient dose of polyethylene glycol in older children. Longer waiting time is also an independent risk factor for inadequate bowel preparation, and it is recommended that the waiting time should not exceed 5.5 hours.


Assuntos
Catárticos , Colonoscopia , Criança , Dieta , Eletrólitos , Humanos , Polietilenoglicóis/efeitos adversos , Pós , Estudos Retrospectivos
2.
J Pak Med Assoc ; 70 [Special Issue](9): 84-87, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33177733

RESUMO

OBJECTIVE: To investigate the clinical efficacy of percutaneous vertebroplasty (PVP) on osteoporotic vertebral compression fracture and relevant issues. METHODS: The data of 80 patients with osteoporotic vertebral compression fracture admitted to Orthopaedics Department, Huanggang Central Hospital from September 2013 to September 2015 was selected for analysis. The data selection was done from December 2018 to February 2019 Under local anaesthesia and C-arm X-ray fluoroscopy, percutaneous kyphoplasty was performed by puncturing into unilateral (or bilateral) pedicle(s) percutaneously and fixing with bone cement. The degree of lower back pain and the recovery of vertebral height in patients were observed and recorded before surgery, 24 hours and 3 months after surgery. RESULTS: All of the 80 patients had a successful surgery. After 24 hours of surgery, 47 (58.75%) patients had no lower back pain, 33 (41.25%) had mild dull pain locally; 74 (92.50%) patients were able to have out-of-bed activity on Day1 after surgery, and 6 (7.50%) patients were able to have out-of-bed activity on Day 3 after surgery. The visual analogue scale (VAS) score and percentage of injured vertebra height to original vertebra height 24 hours and 3 months after surgery were significantly better than those before surgery (P<0.01). The VAS score 3 months after surgery was significantly superior to the VAS score 24 hours after surgery (P<0.01). Compared with 24 hours after surgery, the injured vertebra height was lost 3 months after surgery, but it was not statistically significant (P>0.05). There were no complications, such as infection, haematoma, spinal nerve injury and bone cement toxicosis. CONCLUSIONS: In the treatment of thoracolumbar osteoporotic vertebral compression fracture, PVP can effectively relieve pain, restore vertebral height partially and the efficacy is satisfactory.


Assuntos
Fraturas por Compressão , Cifoplastia , Fraturas por Osteoporose , Fraturas da Coluna Vertebral , Vertebroplastia , Cimentos Ósseos/uso terapêutico , Fraturas por Compressão/cirurgia , Humanos , Fraturas por Osteoporose/cirurgia , Estudos Retrospectivos , Fraturas da Coluna Vertebral/cirurgia , Resultado do Tratamento
3.
Arch Insect Biochem Physiol ; 89(2): 69-86, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25611813

RESUMO

Brown planthopper (BPH) is a damaging insect pest of rice. We used suppression subtractive hybridization (SSH) and mirror orientation selection to identify differentially regulated genes in salivary glands of BPH after feeding on resistant and susceptible varieties. The forward SSH library included 768 clones with insertions ranging from 250 to 1000 bp. After differential screening, a total of 112 transcripts were identified, which included 27 upregulated genes and seven downregulated genes. Several of these transcripts showed sequence homology to known proteins such as trehalase, mucin-like protein, vitellogenin, calcium ion binding protein, and eukaryotic initiation factor-like protein. About half of the transcripts, however, did not match to any sequences in the protein databases currently available. Functional annotation of the transcripts showed gene ontology association with metabolism, signal transduction, and regulatory responses. Notably, many known functional genes were predicted to be secreted proteins. Also, gene expression profiles of the salivary glands of BPH feeding on resistant rice (B5) and susceptible rice (TN1) varieties were compared. Our data provide a molecular resource for future functional studies on salivary glands and will be useful for elucidating the molecular mechanisms between BPH feeding and rice varieties with BPH resistance differences.


Assuntos
Hemípteros/metabolismo , Herbivoria/fisiologia , Oryza/fisiologia , Animais , Perfilação da Expressão Gênica , Regulação da Expressão Gênica , Biblioteca Gênica , Saliva/química , Glândulas Salivares/metabolismo , Técnicas de Hibridização Subtrativa
4.
Shanghai Kou Qiang Yi Xue ; 32(3): 225-229, 2023 Jun.
Artigo em Zh | MEDLINE | ID: mdl-37803973

RESUMO

PURPOSE: To evaluate the shaping ability and microcrack formation of ProTaper Next (PTN) and XP-endo Shaper (XPS) systems in the mesial curved root canals of mandibular molars by using micro-CT scans. METHODS: Sixteen mandibular molars with two independent mesial root canals and curvature ranging from 25° to 35° were randomly divided into two groups. The preparation time was recorded. Pre-and-postoperative images were scanned by micro-CT. The following parameters were evaluated: canal transportation, centering ratio, changes in canal volume, canal/root width ratio and microcrack formation. SPSS 22.0 software package was used to analyze the data. RESULTS: Significant difference (P<0.05) was found for canal transportation at the section of 1, 3, 5, 7 mm from the apical foramen and centering ratio at the section of 1, 3, 7 mm from the apical foramen, where XPS files were superior. There was no significant difference for centering ratio at the section of 5 mm from the apical foramen(P>0.05). XPS groups significantly consumed less time during the preparation(P<0.05). There was no significant difference between the two groups for the increase amount of volume, and canal/root width ratio(P>0.05). Both instruments did not induce new microcrack after preparation. CONCLUSIONS: PTN and XPS can both shape curved canals effectively and safely. XPS showed better centering ability and reduced preparation time during preparation.


Assuntos
Níquel , Preparo de Canal Radicular , Cavidade Pulpar/diagnóstico por imagem , Desenho de Equipamento , Preparo de Canal Radicular/métodos , Titânio , Microtomografia por Raio-X/métodos
5.
Shanghai Kou Qiang Yi Xue ; 31(1): 6-11, 2022 Feb.
Artigo em Zh | MEDLINE | ID: mdl-35587660

RESUMO

PURPOSE: To evaluate the safety and effectiveness of passive ultrasonic irrigation(PUI) in curved root canals, and debris cleaning ability and the amount of root canal transportation of passive ultrasonic irrigation(PUI) in curved root canals. METHODS: A total of 36 mesially curved root canals of mandibular molars with a curvature above 25° were selected. The root canals were prepared with XP-endo Shaper root canal file. The samples were divided into A1 group (curved length>3 mm, syringe irrigation), B1 group(curved length>3 mm, PUI+K file), C1 group(curved length>3 mm, PUI+irrisafe), A2 group (curved length<3 mm, syringe irrigation), B2 group (curved length<3 mm, PUI+K file), and C2 group (curved length<3 mm, PUI+ irrisafe) (n=6). Micro-CT scans were performed on all samples before and after irrigation, and the volume increase in the root canal after irrigation and the transportation of the root canal were calculated. SPSS 22.0 software package was used to analyze the data. RESULTS: In the apical area of the root canal with a curved length greater than 3 mm, the root canal volume increase in the PUI+irrisafe group was significantly greater than that of the PUI+K file and syringe irrigation (P<0.05), and at 5 mm section, the transportation of the root canal formed by PUI+irrisafe was significantly lower than that of the PUI+K file (P<0.05), but there was no significant difference from syringe irrigation (P>0.05); in root canals with a curved length less than 3 mm, root canal volume increment of the file group was significantly greater than that of syringe irrigation (P<0.05), but there was no significant difference between the root canal transportation and syringe irrigation(P<0.05). CONCLUSIONS: In root canals with larger curved length, passive ultrasonic irrigation combined with a pre-curved file can obtain a better cleaning effect, while in root canals with smaller curved length, both K file and pre-curved file with passive ultrasonic irrigation are safe and effective.


Assuntos
Cavidade Pulpar , Preparo de Canal Radicular , Cavidade Pulpar/diagnóstico por imagem , Dente Molar , Irrigantes do Canal Radicular/efeitos adversos , Preparo de Canal Radicular/efeitos adversos , Tratamento do Canal Radicular , Ultrassom
6.
J Environ Sci (China) ; 22(11): 1657-65, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21235151

RESUMO

The performance of combined Fenton oxidation and membrane bioreactor (MBR) process for the advanced treatment of an effluent from an integrated dyeing wastewater treatment plant was evaluated. The experimental results revealed that under the optimum Fenton oxidation conditions (initial pH 5, H2O2 dosage 17 mmol/L, and Fe2+ 1.7 mmol/L) the average total organic carbon (TOC) and color removal ratios were 39.3% and 69.5% after 35 min of reaction, respectively. Results from Zahn-Wallens Test also represented that Fenton process was effective to enhance the biodegradability of the test wastewater. As for the further purification of MBR process, TOC removal capacity was examined at different hydraulic retention times (HRT) of 10, 18 and 25 hr. Under the optimum HRT of 18 hr, the average TOC concentration and color of the final MBR effluent were 16.8 mg/L and 2 dilution time, respectively. The sludge yield coefficient was 0.13 g MLSS/g TOC and TOC degradation rate was 0.078 kg TOC/(m3 x day). The final effluent of MBR can meet the reuse criteria of urban recycling water - water quality standard for miscellaneous water consumption GBT18920-2002.


Assuntos
Reatores Biológicos , Membranas Artificiais , Eliminação de Resíduos Líquidos/métodos , Purificação da Água/métodos , Oxirredução
7.
J Int Med Res ; 48(2): 300060519835084, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30880529

RESUMO

Percutaneous vertebroplasty (PVP) is a minimally invasive treatment that has been widely used for the treatment of osteoporotic vertebral compression fractures and vertebral tumors. However, the maximum number of vertebral segments treated in a single PVP remains controversial. Furthermore, PVP may cause complications, including cement leakage, pulmonary embolism, bone cement toxicity, and spinal nerve-puncture injury. We report the rare case of a patient who underwent multilevel PVP for vertebral metastases, with no bone cement leakage or spinal cord injury, but who developed temporary paraparesis.


Assuntos
Fraturas por Compressão , Fraturas por Osteoporose , Fraturas da Coluna Vertebral , Vertebroplastia , Cimentos Ósseos/efeitos adversos , Fraturas por Compressão/diagnóstico por imagem , Fraturas por Compressão/cirurgia , Humanos , Paraparesia/etiologia , Estudos Retrospectivos , Fraturas da Coluna Vertebral/diagnóstico por imagem , Fraturas da Coluna Vertebral/cirurgia , Resultado do Tratamento , Vertebroplastia/efeitos adversos
8.
Angew Chem Int Ed Engl ; 48(29): 5287-90, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19544334

RESUMO

Making connections: A hydroxy-centered trinuclear nickel cluster has been employed to construct a highly connected, highly symmetric framework with a uninodal nine-connected topology. An array of triakis tetrahedra leads to a biporous intersecting-channel system (see picture).


Assuntos
Radical Hidroxila/química , Níquel/química , Polímeros/química , Adsorção , Ácidos Carboxílicos/química , Cristalografia por Raios X , Modelos Moleculares , Estrutura Molecular , Porosidade , Piridinas/química
9.
Medicine (Baltimore) ; 98(8): e14634, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30813202

RESUMO

BACKGROUND: The purpose of this meta-analysis was to compare the effectiveness and safety of cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures. METHODS: We searched PUBMED, EMBASE, Cochrane Library, and Google Scholar from their inception to February 2016. All RCTs comparing cemented with uncemented hemiarthroplasty for displaced femoral neck fractures were eligible. The participants who underwent primary hemiarthroplasty for unilateral femoral neck fracture were older than 55 and the mean age of more than 75 years old. For the trials before 2006 used old designed prostheses, so we excluded trails before 2006 which used old designed prostheses. Outcomes of interest include postoperative hip function, Harris hip score (HHS), mortality, reoperation rate, complications, operation time, intraoperative blood loss. Two reviewers independently evaluated the included studies and extracted data into RevMan. Quality Assessments were classified by agreement of 2 authors based on the Cochrane tool. RESULTS: Seven trials were eligible. Postoperative hip function at 12 months cemented hemiarthroplasty was better than that in uncemented hemiarthroplasty (OR = 0.52, 95% CI, 0.31-0.88; P = .01). Postoperative fractures rates in cemented hemiarthroplasty were lower than that in uncemented hemiarthroplasty (OR = 0.09, 95% CI, 0.02-0.38; P = .001). Also, the interoperative fracture rates in cemented hemiarthroplasty were lower than that in uncemented hemiarthroplasty (OR = 0.29, 95% CI, 0.13-0.68; P = .004). Shorter operation time was achieved in uncemented hemiarthroplasty than that in cemented hemiarthroplasty (WMD = 8.22 min, 95% CI, 5.57-10.86 min; P<.00001). There was no significant difference between the 2 groups with HHS, mortality, wound infection, dislocation, general complications, reoperation rate, and intraoperative blood loss. CONCLUSION: The available evidence indicates that compared with uncemented hemiarthroplasty cemented hemiarthroplasty achieved better postoperative hip function, less postoperative, and interoperative fractures in displaced femoral neck fracture. Uncemented hemiarthroplasty achieved shorter operation time. There was no difference between the 2 groups with HHS at 1 year, mortality, and complications.


Assuntos
Cimentos Ósseos/uso terapêutico , Fraturas do Colo Femoral/cirurgia , Hemiartroplastia , Complicações Pós-Operatórias , Fraturas Mal-Unidas , Hemiartroplastia/efeitos adversos , Hemiartroplastia/métodos , Humanos , Avaliação de Resultados em Cuidados de Saúde , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Ensaios Clínicos Controlados Aleatórios como Assunto
10.
J Chromatogr A ; 1565: 130-137, 2018 Aug 31.
Artigo em Inglês | MEDLINE | ID: mdl-29941198

RESUMO

In this paper, a novel embeded elliptic cylindrical posts (ECPs) with large surface area and wide effective width, which could support more stationary phase and decrease the pressure drop, is applied on the micro-fabricated gas chromatographic (µGC) column. Compared with µGC column with cylindrical posts (CPs), the surface area and effective width of µGC column with ECPs are increased by 29% and 30%. Separation experiments are performed under the same head pressure at column inlet: in experiments of separating mixture 1, the column efficiency of the µGC column with ECPs for C9 has a 76% improvement, and the separation resolution between C8 and C9 also has a 34% improvement; in experiments of separating mixture 2, seven kinds of analytes can be identified by the µGC column with ECPs less than ten minutes, while, only six kinds can be identified by the µGC column with CPs in almost the same time. In detail, the column efficiency of the µGC column with ECPs for toluene has a 129% improvement, and the separation resolution between benzene and toluene also has a 56.4% improvement. Hence, the µGC column with the inner structures of ECPs is a valid means to improve column efficiency and resolution in a lower pressure drop.


Assuntos
Cromatografia Gasosa/instrumentação , Cromatografia Gasosa/métodos , Dimetilpolisiloxanos/química , Processamento de Imagem Assistida por Computador , Microscopia Eletrônica de Varredura , Microtecnologia
11.
Pain Res Manag ; 2017: 3926318, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28239257

RESUMO

Percutaneous vertebroplasty (PVP) has been shown to release spinal pain and stabilize the vertebral body. PVP is suggested as an alternative treatment in spinal metastasis. Although cervical metastases is less prevalent than thoracic and lumbar spine, PVP procedure in cervical vertebrae remains technical challenging. We retrospectively analyzed the data from patients (n = 9) who underwent PVP using anterolateral approach to treat severe neck pain and restricted cervical mobility from metastatic disease. Patients were rated using modified Tokuhashi score and Tomita score before the procedure. Visual analog scale (VAS), neck disability index (NDI), analgesic use, and imaging (X-ray or CT) were evaluated before PVP and 3 days, 3 months, and 6 months after PVP. All patients were in late stage of cancer evaluated using modified Tokuhashi and Tomita score. The cement leakage rate was 63.6% (14 of the 22 vertebrae) with no severe complications. VAS, NDI, and analgesic use were significantly decreased 3 days after the procedure and remained at low level until 6 months of follow-up. Our result suggested PVP effectively released the pain from patients with cervical metastasis. The results warrant further clinical investigation.


Assuntos
Vértebras Cervicais/cirurgia , Discotomia Percutânea/métodos , Cervicalgia/cirurgia , Vertebroplastia/métodos , Idoso , Cimentos Ósseos/uso terapêutico , Avaliação da Deficiência , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Cervicalgia/diagnóstico por imagem , Cervicalgia/etiologia , Medição da Dor , Estudos Retrospectivos , Neoplasias da Coluna Vertebral/complicações , Neoplasias da Coluna Vertebral/secundário , Tomografia Computadorizada por Raios X , Resultado do Tratamento
12.
Exp Ther Med ; 5(1): 128-132, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23251253

RESUMO

Langerhans cell histiocytosis (LCH) is extremely rare in the lumbar spine of adults. The radiological features typically manifest as vertebral tumors. The exact etiology of LCH remains unknown. Langerhans cells may cause local or systemic effects. The most frequent sites of these bony lesions are the skull, femur, mandible, pelvis and spine. To date, only 3 spinal LCH cases treated by percutaneous vertebroplasty (PVP) have been reported. The present study reports a case of LCH of the fourth lumbar vertebra (L4) in a 51-year-old male with a 10-day history of low back pain, limited waist motion and right lower limb numbness. The patient was treated using PVP. The use of PVP for treating LCH of the spine was successful. The present study provides an up-to-date literature overview of LCH.

13.
Glycobiology ; 17(6): 568-77, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17317719

RESUMO

Ganglioside GM3, one of the sialic acid containing glycosphingolipids, is known to form clusters in lipid microdomains, which serve as platforms for effective signal transduction. In an attempt to clarify the GM3 cluster effect, we enzymatically synthesized GM3 mimetic polymer (GM3-p), with an acrylamide backbone from LacCer mimetic polymer (LacCer-p). Interestingly, GM3-p, but not LacCer-p, reversibly inhibited proliferation of NIH3T3 cells, which are normally resistant to exogenously added GM3. Moreover, we found that the introduction of carbonic acid into the acrylamide chain aided well-oriented cluster formation and enhanced the inhibitory effect of GM3-p. Since sialyllactosyl polymer and GM4 mimetic polymer, but not GM2 mimetic polymer, also inhibited cell proliferation, sialic acid-galactose units must be essential for the biological activity of GM3-p. These results suggest that the formation of sialic acid-galactose clusters is necessary for the suppressive effect of GM3-p. GM3-p treatment did not affect the serum-dependent activation of ERK1/2 or c-fos expression, but caused a reduction in the gene and/or protein expression of cyclin D1, cyclin E, cyclin-dependent kinase (cdk)4, and cdk2, which are involved in the cell cycle. Therefore, GM3-p inhibits cell proliferation by reducing cyclin D1-cdk4 and cyclin E-cdk2 complexes without affecting growth factor signaling from serum to c-fos.


Assuntos
Biomimética , Proliferação de Células/efeitos dos fármacos , Gangliosídeo G(M3)/química , Ácido N-Acetilneuramínico/farmacologia , Polímeros/química , Animais , Sobrevivência Celular/efeitos dos fármacos , Relação Dose-Resposta a Droga , Camundongos , Células NIH 3T3
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