RESUMO
BACKGROUND: The aim of this research was to analyse the current literature on displaced dental implants in the mandibular body, including local and systemic variables related to their cause, and to identify the most frequent location. METHODS: The study conducted a search of three databases (Pubmed, Scopus, and Web of Science) using specific index terms such as 'dental implant', 'displacement', 'dislocation', 'displaced', and 'mandible'. The analysis focused on the direction of displacement and the characteristics of the bone tissue (bone quality, density, and quantity) in cases where dental implants were displaced. RESULTS: A total of 371 articles were obtained. Thirteen of these articles were selected and read in full. To define bone quality, the Lekholm and Zarb classification, modified by Rosas et al., was used. The type II-B bone, which is characterized by thick cortical bone surrounding cancellous bone with extremely wide medullary spaces, presented the largest number of complications. Twenty-two cases were found in which the displacement direction was horizontal. Of these, four were displaced vestibularly, fourteen lingually, and four remained in the center. Additionally, 24 cases presented vertical displacement, with 12 displaced towards the inferior border of the mandible, 9 towards the middle or adjacent to the inferior dental nerve canal, and 3 above the inferior dental nerve canal. CONCLUSION: The accidental displacement of implants within the mandibular body is associated with various risk factors, including the characteristics of the bony trabeculum and the size of the medullary spaces. It is reasonable to suggest that only an adequate pre-surgical diagnostic evaluation, with the help of high-resolution tomographic images that allow a previous evaluation of these structures, will help to have better control over the other factors, thus minimizing the risk of displacement.
Assuntos
Implantes Dentários , Mandíbula , Humanos , Implantes Dentários/efeitos adversos , Mandíbula/diagnóstico por imagem , Fatores de Risco , Migração de Corpo Estranho/prevenção & controle , Migração de Corpo Estranho/etiologia , Densidade Óssea , Falha de Restauração DentáriaRESUMO
Arthropod-borne viruses (arboviruses) require replication across a wide range of temperatures to perpetuate. While vertebrate hosts tend to maintain temperatures of approximately 37°C-40°C, arthropods are subject to ambient temperatures which can have a daily fluctuation of > 10°C. Temperatures impact vector competence, extrinsic incubation period, and mosquito survival unimodally, with optimal conditions occurring at some intermediate temperature. In addition, the mean and range of daily temperature fluctuations influence arbovirus perpetuation and vector competence. The impact of temperature on arbovirus genetic diversity during systemic mosquito infection, however, is poorly understood. Therefore, we determined how constant extrinsic incubation temperatures of 25°C, 28°C, 32°C, and 35°C control Zika virus (ZIKV) vector competence and population dynamics within Aedes aegypti and Aedes albopictus mosquitoes. We also examined fluctuating temperatures which better mimic field conditions in the tropics. We found that vector competence varied in a unimodal manner for constant temperatures peaking between 28°C and 32°C for both Aedes species. Transmission peaked at 10 days post-infection for Aedes aegypti and 14 days for Aedes albopictus. Conversely, fluctuating temperature decreased vector competence. Using RNA-seq to characterize ZIKV population structure, we identified that temperature alters the selective environment in unexpected ways. During mosquito infection, constant temperatures more often elicited positive selection whereas fluctuating temperatures led to strong purifying selection in both Aedes species. These findings demonstrate that temperature has multiple impacts on ZIKV biology, including major effects on the selective environment within mosquitoes.
Assuntos
Aedes/virologia , Aptidão Genética , Mosquitos Vetores/virologia , Seleção Genética , Temperatura , Infecção por Zika virus/transmissão , Zika virus/crescimento & desenvolvimento , Aedes/classificação , Aedes/genética , Animais , Chlorocebus aethiops , Saliva/virologia , Células Vero , Carga Viral , Infecção por Zika virus/virologiaRESUMO
BACKGROUND: It has been demonstrated that dental restorations with rough surfaces can have several disadvantages such as pigment retention or plaque accumulation, which can facilitate caries formation, color variation, loss of brightness, degradation of restoration, among others. The present study aimed to assess surface roughness in bulk fill and conventional nanohybrid resins with and without polishing, controlling the oxygen inhibited layer. METHODS: This in vitro and longitudinal experimental study consisted of 120 resin blocks of 6 mm diameter and 4 mm depth, divided into two groups: Bulk Fill (Tetric® N-Ceram Bulk-fill, Opus Bulk Fill APS, Filtek™ Bulk Fill) and conventional nanohybrid (Tetric® N-Ceram, Opallis EA2, Filtek™ Z250 XT). Each resin group was divided into two equal parts, placing glycerin only on one of them, in order to control the oxygen inhibited layer. Subsequently, the surface roughness was measured before and after the polishing procedure with Sof-Lex discs. The data were analyzed with the T-test for related measures, and for comparison between groups before and after polishing, the non-parametric Kruskal Wallis test with the Bonferroni post hoc was used, considering a significance level of p < 0.05. RESULTS: Before polishing, the resin composites with the lowest surface roughness were Opus Bulk Fill APS (0.383 ± 0.186 µm) and Opallis EA2 (0.430 ± 0. 177 µm) with and without oxygen inhibited layer control, respectively; while after polishing, those with the lowest surface roughness were Opus Bulk Fill APS (0.213 ± 0.214 µm) and Tetric N-Ceram (0.097 ± 0.099 µm), with and without oxygen inhibited layer control, respectively. Furthermore, before and after polishing, all resins significantly decreased their surface roughness (p < 0.05) except Opus Bulk Fill APS resin with oxygen inhibited layer control (p = 0.125). However, when comparing this decrease among all groups, no significant differences were observed (p < 0.05). CONCLUSION: The Opus Bulk Fill APS resin with oxygen inhibited layer control presented lower surface roughness both before and after polishing, being these values similar at both times. However, after polishing the other bulk fill and conventional nanohybrid resins with and without oxygen inhibited layer control, the surface roughness decreased significantly in all groups, being this decrease similar in all of them.
Assuntos
Polimento Dentário , Oxigênio , Resinas Compostas , Polimento Dentário/métodos , Humanos , Teste de Materiais , Propriedades de SuperfícieRESUMO
PURPOSE: Ranitidine has been found to have an impact on bone metabolism by suppressing osteoclastogenesis. We hypothesized that the use of ranitidine would impair bone healing and implant osseointegration. This study investigated the effect of postoperative administration of ranitidine on bone healing and osseointegration in rats. MATERIALS AND METHODS: Twenty-two Sprague-Dawley rats underwent surgery to create a unicortical bone defect in each tibia. A titanium implant was placed on the right tibial defect, whereas the contralateral defect was left unfilled. After surgery, the rats were randomly divided into 2 groups receiving a daily dose of ranitidine or saline solution for 14 days and then euthanized for assessment of bone healing and osseointegration using micro-computed tomography (CT) and histomorphometry. RESULTS: Micro-CT analysis of the bone defect showed a larger bone defect volume in the ranitidine group (0.82 ± 0.13 µL vs 0.66 ± 0.16 µL, P = .034), thinner cortical thickness (0.54 ± 0.07 mm vs 0.63 ± 0.11 mm, P = .026), and less bone regeneration at the defect site (40% ± 12% vs 57% ± 11%, P = .003). Implant-site micro-CT analysis showed less osseointegration in the ranitidine group (34.1% ± 2.7% vs 43.5% ± 2.1%, P = .014), and implant-site histologic analysis showed less medullary (P = .021), cortical (P = .001), and total (P = .003) bone-implant contact and less peri-implant bone volume-tissue volume (P = .002) in the ranitidine group. Histologic analysis for osteoclastic activity showed a lower number of osteoclasts in the ranitidine group (4.8 ± 2.4 mm-2 vs 9.1 ± 2.1 mm-2, P = .026). CONCLUSIONS: The postoperative use of ranitidine impaired bone healing and osseointegration.
Assuntos
Implantes Dentários , Osseointegração , Animais , Ranitidina , Ratos , Ratos Sprague-Dawley , Tíbia/diagnóstico por imagem , Tíbia/cirurgia , Titânio , Microtomografia por Raio-XRESUMO
A hydroxycinnamic acid derivative, namely ferulic acid (FA) has been successfully encapsulated in polymeric nanoparticles (NPs) based on poly(lactic-co-glycolic acid) (PLGA). FA-loaded polymeric NPs were prepared from O/W nano-emulsion templates using the phase inversion composition (PIC) low-energy emulsification method. The obtained PLGA NPs exhibited high colloidal stability, good drug-loading capacity, and particle hydrodynamic diameters in the range of 74 to 117 nm, depending on the FA concentration used. In vitro drug release studies confirmed a diffusion-controlled mechanism through which the amount of released FA reached a plateau at 60% after 6 hours-incubation. Five kinetic models were used to fit the FA release data as a function of time. The Weibull distribution and Korsmeyer-Peppas equation models provided the best fit to our experimental data and suggested quasi-Fickian diffusion behaviour. Moderate dose-response antioxidant and radical scavenging activities of FA-loaded PLGA NPs were demonstrated using the DPPHË assay achieving inhibition activities close to 60 and 40%, respectively. Cell culture studies confirmed that FA-loaded NPs were not toxic according to the MTT colorimetric assay, were able to internalise efficiently SH-SY5Y neuronal cells and supressed the intracellular ROS-level induced by H2O2 leading to 52% and 24.7% of cellular viability at 0.082 and 0.041 mg mL-1, respectively. The permeability of the NPs through the blood brain barrier was tested with an in vitro organ-on-a-chip model to evaluate the ability of the FA-loaded PLGA and non-loaded PLGA NPs to penetrate to the brain. NPs were able to penetrate the barrier, but permeability decreased when FA was loaded. These results are promising for the use of loaded PLGA NPs for the management of neurological diseases.
Assuntos
Nanopartículas , Neuroblastoma , Humanos , Copolímero de Ácido Poliláctico e Ácido Poliglicólico , Ácidos Cumáricos/farmacologia , Ácido Poliglicólico , Ácido Láctico , Barreira Hematoencefálica , Peróxido de Hidrogênio , Tamanho da Partícula , Portadores de Fármacos/farmacologiaRESUMO
Peru was the country with the highest COVID-19 case fatality rate worldwide during second wave of infection, with dentists and pre-professional students being susceptible to infection due to clinical procedures they perform. This situation could have generated some kind of psychological disorder within this group. Therefore, the present study aimed to assess how COVID-19 pandemic affected this population group during second wave, in relation to depression, anxiety and stress. This observational and cross-sectional study in 368 Peruvian dentists (186 students and 182 professionals), was carried out during August to November 2021. The DASS-21 Scale was used to diagnose depression, anxiety and stress. For the statistical analysis, Pearson's chi-square test was used, in addition to a logit model using odds ratio (OR) to evaluate depression, anxiety and stress with the following factors: gender, age group, marital status, monthly family income, children, academic level, history of COVID-19, COVID-19 symptomatology, close relative with COVID-19, living with vulnerable people and work dedication. In addition, predictive models were constructed considering all possible significant causes. A significance level of p < 0.05 was considered. Dental students and professionals presented significant differences in levels of depression, anxiety and stress (p < 0.001, p = 0.022, p = 0.001; respectively). Male students were 56% less likely to develop stress (OR 0.44; CI 0.22-0.85) compared to females; while those unmarried were 81% less likely to develop stress (OR 0.19; CI 0.04-0.85). Likewise, those with children were 83% less likely to develop stress (OR 0.17; CI 0.06-0.52) and 65% less likely to develop depression (OR 0.35; CI 0.15-0.80). In addition, COVID-19 asymptomatics were 60% less likely to develop depression (OR 0.40; CI 0.17-0.92). However, having relatives with COVID-19 caused almost three times the probability of developing depression (OR 2.96; CI 1.29-6.79) and twice the probability of developing stress (OR 2.49; CI 1.07-5.78). As for dental professionals, it was noticed that those unmarried had almost three times the probability of developing stress (OR 2.93; CI 1.38-6.23); while those who only worked had twice the probability of developing stress (OR 2.37; CI 1.17-4.78). Dental students had a higher prevalence of depression, anxiety and stress. In addition, having children and being asymptomatic were protective predictors for depression, while being male, unmarried and having children were protective predictors for stress. However, having a relative with COVID-19 was a risk predictor for depression and stress. In professionals, only working and being unmarried were risk predictors for stress.
Assuntos
COVID-19 , Pandemias , Ansiedade/psicologia , COVID-19/epidemiologia , Criança , Estudos Transversais , Depressão/psicologia , Feminino , Humanos , Masculino , SARS-CoV-2 , Estresse Psicológico/epidemiologia , Estresse Psicológico/psicologia , Estudantes de OdontologiaRESUMO
Fluoride intoxication has been shown to produce diverse deleterious metabolic alterations within the cell. To determine the effects of sodium fluoride (NaF) treatment on malondialdehyde (MDA) levels and on the activity of antioxidant enzymes in rat erythrocytes, Male Wistar rats were treated with 50 ppm of NaF or were untreated as controls. Erythrocytes were obtained from rats sacrificed weekly for up to eight weeks and the concentration of MDA in erythrocyte membrane was determined. In addition, the activity of the enzymes superoxide, dismutase, catalase, and glutathione peroxidase were determined. Treatment with NaF produces an increase in the concentration of malondialdehyde in the erythrocyte membrane only after the eight weeks of treatment. On the other hand, antioxidant enzyme activity was observed to increase after the fourth week of NaF treatment. In conclusion, intake of NaF produces alterations in the erythrocyte of the male rat, which indicates induction of oxidative stress.
Assuntos
Antioxidantes/metabolismo , Eritrócitos/metabolismo , Malondialdeído/metabolismo , Fluoreto de Sódio/metabolismo , Animais , Catalase/metabolismo , Masculino , Oxirredução , Estresse Oxidativo , Ratos , Superóxido Dismutase/metabolismoRESUMO
Fluoride is naturally present in the earth's crust and can be found in rocks, coal, and clay; thus, it can be found in small quantities in water, air, plants, and animals. Therefore, humans are exposed to fluoride through food, drinking water, and in the air they breathe. Flouride is essential to maintain bone strength and to protect against dental decay, but if it is absorbed too frequently, it can cause tooth decay, osteoporosis, and damage to kidneys, bones, nerves, and muscles. Therefore, the present work was aimed at determining the effect of intake of sodium fluoride (NaF) as an apoptosis inducer in leukocytes of rats treated for eight weeks with 1 or 50 parts per million (ppm) NaF. Expression of p53, bcl-2, and caspade-3 were used as apoptotic and general metabolism indicators of leukocyte-like indicators of the (INT) oxidation system. Male rats were exposed to NaF (1 and 500 ppm) for eight weeks, and then sacrificed weekly to obtain blood samples. Expression of p53, bcl-2, and caspase-3 were determined in leukocytes by Western blot, and general metabolism of leukocytes was analyzed with a commercial kit. We found changes in the expression of the proteins described, especially when the animals received 50 ppm of NaF. These results indicate that NaF intoxication can be an apoptosis inducer in rat leukocytes treated with the compound for eight weeks.
Assuntos
Apoptose , Leucócitos/efeitos dos fármacos , Fluoreto de Sódio/farmacologia , Animais , Proteínas Reguladoras de Apoptose/genética , Proteínas Reguladoras de Apoptose/metabolismo , Leucócitos/metabolismo , Masculino , Ratos , Ratos WistarRESUMO
International scientific experts in food, nutrition, dietetics, endocrinology, physical activity, paediatrics, nursing, toxicology and public health met in Lisbon on 2â»4 July 2017 to develop a Consensus on the use of low- and no-calorie sweeteners (LNCS) as substitutes for sugars and other caloric sweeteners. LNCS are food additives that are broadly used as sugar substitutes to sweeten foods and beverages with the addition of fewer or no calories. They are also used in medicines, health-care products, such as toothpaste, and food supplements. The goal of this Consensus was to provide a useful, evidence-based, point of reference to assist in efforts to reduce free sugars consumption in line with current international public health recommendations. Participating experts in the Lisbon Consensus analysed and evaluated the evidence in relation to the role of LNCS in food safety, their regulation and the nutritional and dietary aspects of their use in foods and beverages. The conclusions of this Consensus were: (1) LNCS are some of the most extensively evaluated dietary constituents, and their safety has been reviewed and confirmed by regulatory bodies globally including the World Health Organisation, the US Food and Drug Administration and the European Food Safety Authority; (2) Consumer education, which is based on the most robust scientific evidence and regulatory processes, on the use of products containing LNCS should be strengthened in a comprehensive and objective way; (3) The use of LNCS in weight reduction programmes that involve replacing caloric sweeteners with LNCS in the context of structured diet plans may favour sustainable weight reduction. Furthermore, their use in diabetes management programmes may contribute to a better glycaemic control in patients, albeit with modest results. LNCS also provide dental health benefits when used in place of free sugars; (4) It is proposed that foods and beverages with LNCS could be included in dietary guidelines as alternative options to products sweetened with free sugars; (5) Continued education of health professionals is required, since they are a key source of information on issues related to food and health for both the general population and patients. With this in mind, the publication of position statements and consensus documents in the academic literature are extremely desirable.
Assuntos
Bebidas/normas , Qualidade de Produtos para o Consumidor/normas , Inocuidade dos Alimentos , Alimentos/normas , Adoçantes não Calóricos/normas , Adoçantes Calóricos/normas , Valor Nutritivo , Animais , Bebidas/efeitos adversos , Glicemia/metabolismo , Consenso , Diabetes Mellitus/sangue , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/terapia , Ingestão de Energia , Alimentos/efeitos adversos , Rotulagem de Alimentos/normas , Humanos , Adoçantes não Calóricos/efeitos adversos , Adoçantes Calóricos/efeitos adversos , Obesidade/epidemiologia , Obesidade/fisiopatologia , Obesidade/terapia , Recomendações Nutricionais , Medição de Risco , Redução de PesoRESUMO
Arthropod-borne viruses (arboviruses), such as Zika virus, chikungunya virus, and West Nile virus (WNV), pose continuous threats to emerge and cause large epidemics. Often, these events are associated with novel virus variants optimized for local transmission that first arise as minorities within a host. Thus, the conditions that regulate the frequency of intrahost variants are important determinants of emergence. Here, we describe the dynamics of WNV genetic diversity during its transmission cycle. By temporally sampling saliva from individual mosquitoes, we demonstrate that virus populations expectorated by mosquitoes are highly diverse and unique to each feeding episode. After transmission to birds, however, most genetic diversity is removed by strong purifying selection. Further, transmission of potentially mosquito-adaptive WNV variants is strongly influenced by genetic drift in mosquitoes. These results highlight the complex evolutionary forces a novel virus variant must overcome to alter infection phenotypes at the population level.
Assuntos
Culicidae/fisiologia , Febre do Nilo Ocidental/transmissão , Vírus do Nilo Ocidental/genética , Animais , Aves , Culicidae/virologia , DNA Mitocondrial/genética , DNA Mitocondrial/metabolismo , Evolução Molecular , Variação Genética , Insetos Vetores/virologia , Fenótipo , RNA Viral/genética , RNA Viral/metabolismo , Saliva/virologia , Febre do Nilo Ocidental/patologia , Febre do Nilo Ocidental/veterinária , Vírus do Nilo Ocidental/fisiologiaRESUMO
The recent emergence of both chikungunya and Zika viruses in the Americas has significantly expanded their distribution and has thus increased the possibility that individuals may become infected by more than one Aedes aegypti-borne virus at a time. Recent clinical data support an increase in the frequency of coinfection in human patients, raising the likelihood that mosquitoes could be exposed to multiple arboviruses during one feeding episode. The impact of coinfection on the ability of relevant vector species to transmit any of these viruses (that is, their vector competence) has not been determined. Thus, we here expose Ae. aegypti mosquitoes to chikungunya, dengue-2 or Zika viruses, both individually and as double and triple infections. Our results show that these mosquitoes can be infected with and can transmit all combinations of these viruses simultaneously. Importantly, infection, dissemination and transmission rates in mosquitoes are only mildly affected by coinfection.
Assuntos
Aedes/virologia , Febre de Chikungunya/transmissão , Vírus Chikungunya , Coinfecção/virologia , Vírus da Dengue , Infecção por Zika virus/transmissão , Zika virus , Células A549 , Animais , Arbovírus , Febre de Chikungunya/virologia , Chlorocebus aethiops , Geografia , Humanos , Saliva , Células Vero , Infecção por Zika virus/virologiaRESUMO
AbstractStarting in 2013-2014, the Americas have experienced a massive outbreak of Zika virus (ZIKV) which has now reached at least 49 countries. Although most cases have occurred in South America and the Caribbean, imported and autochthonous cases have occurred in the United States. Aedes aegypti and Aedes albopictus mosquitoes are known vectors of ZIKV. Little is known about the potential for temperate Aedes mosquitoes to transmit ZIKV. Aedes vexans has a worldwide distribution, is highly abundant in particular localities, aggressively bites humans, and is a competent vector of several arboviruses. However, it is not clear whether Ae. vexans mosquitoes are competent to transmit ZIKV. To determine the vector competence of Ae. vexans for ZIKV, wild-caught mosquitoes were exposed to an infectious bloodmeal containing a ZIKV strain isolated during the current outbreak. Approximately 80% of 148 mosquitoes tested became infected by ZIKV, and approximately 5% transmitted infectious virus after 14 days of extrinsic incubation. These results establish that Ae. vexans are competent ZIKV vectors. Their relative importance as vectors (i.e., their vectorial capacity) depends on feeding behavior, longevity, and other factors that are likely to vary in ecologically distinct environments.
Assuntos
Aedes/virologia , Surtos de Doenças , Insetos Vetores/virologia , Infecção por Zika virus/epidemiologia , Zika virus/isolamento & purificação , Animais , Feminino , Humanos , América do Norte , Saliva/virologia , Infecção por Zika virus/virologiaRESUMO
Diastasis of the intermaxillary suture is an unusual complication of the transsphenoidal approach to the sella turcica. Over the 1977-1989 twelve-year-period, 192 procedures were performed at our Center. This complication occurred only once, in a senile patient with marked osteoporosis. It did not alter the course of the operation, nor did it create additional problems during the postoperative period.
Assuntos
Luxações Articulares/etiologia , Maxila/lesões , Complicações Pós-Operatórias , Adenoma/cirurgia , Idoso , Humanos , Masculino , Neoplasias Hipofisárias/cirurgia , Osso EsfenoideRESUMO
In order to compare the clinical utilization of diagnostic dyes to identify carious dentin, the present in vivo study compared two caries-detector dyes, acid red (1% acid red in propylene glycol wt/wt) and povidone-iodine (8% povidone-iodine in water wt/vol). A total of 221 cavities prepared by 19 senior dental students under the supervision of two teachers at the Universidad Nacional Autónoma de México Dental School were used. Dyes were applied double-blind under standardized conditions to at least two teeth of the same patient. Data were analyzed using the Mantel-Haenszel chi-square test and a test of proportions. Results showed that molars or premolars did not appear to be positively stained more frequently by one dye or another. Also, 36.7% of teeth tested positive to either one of the two dyes. Prudent utilization of either acid red or povidone-iodine appeared to be equally useful in assisting clinical decisions concerning cavity size while restoring dentinal lesions. However, povidone-iodine may be preferred in clinical settings where acid red is expensive and/or difficult to obtain. Further research is necessary to establish accurately the mechanism of staining by povidone-iodine.
Assuntos
Corantes , Testes de Atividade de Cárie Dentária , Cárie Dentária/diagnóstico , Distribuição de Qui-Quadrado , Preparo da Cavidade Dentária , Método Duplo-Cego , Humanos , Povidona-Iodo , Valor Preditivo dos Testes , Propilenoglicóis , Rodaminas , Sensibilidade e Especificidade , Resultado do TratamentoRESUMO
Chylothorax is a well-known, albeit infrequent, complication in certain neoplasias including lymphomas. The continuing loss of chyle leads to a profound deterioration in patients' nutritional and immunological status, prevented only by appropriate early nutritional support. There is currently some dispute over its handling, particularly with regard to the most appropriate type of nutritional support and the suitability of conservative treatment versus surgery. The present paper describes the case of a 41-year-old patient diagnosed as having secondary chylothorax following B-cell lymphoma where mixed nutritional support (fat-free enteral nutrition by mouth and total parenteral nutrition) was given, followed by talc pleurodesis, with optimal results. There is a review of the literature and a discussion of the most controversial aspects of its management.
Assuntos
Quilotórax/terapia , Linfoma de Células B/complicações , Apoio Nutricional , Adulto , Quilotórax/etiologia , Humanos , MasculinoRESUMO
Multidisciplinary experts in the areas of nutrition and health met in Chinchón, Madrid, on November 25-26, 2013 under the auspices of the Fundación para la Investigación Nutricional (Nutrition Research Foundation) and with the collaboration of the Madrid Regional Government's Health Ministry, the International Sweeteners Association and the Carlos III Health Institute CIBER of Physiopathology of Obesity and Nutrition. They analyzed the current status of scientific knowledge on low- and no-calorie sweeteners (LNCS) and developed a consensus Decalogue on their use; this constitutes the Chinchón Declaration. Sweeteners, including sugar, represent a subject of undeniable interest and are currently a popular topic, although areas relating to their safety and benefits remain unknown to segments of academia and the general public. The nature of LNCS makes them vulnerable to biased and even contradictory information. They are food additives that are broadly used as sugar substitutes to sweeten foods, medicines and food supplements when non-nutritional or non-caloric alternatives are needed. The Chinchón Decalogue is the outcome of a meeting for reflection and consensus by a group of experts with backgrounds in different scientific disciplines (toxicology, clinical nutrition, community nutrition, physiology, food science, public health, pediatrics, endocrinology and nutrition, nursing, pharmaceutical care and food legislation). The Decalogue includes different aspects of LNCS related to regulation, use, benefits and safety. In general, benefits of LNCS have been traditionally neglected in comparison with the tendency for emphasising unexisting or unproven possible risks. The need to strengthen research on LNCS in Spain was emphasized, as well as the need to educate both professionals and the public.
Expertos de carácter multidisciplinar de las áreas de conocimiento de la nutrición y la salud reunidos en Chinchón, Madrid, los días 25 y 26 de noviembre de 2013 , bajo los auspicios de la Fundación para la Investigación Nutricional y con la colaboración de la Consejería de Sanidad del Gobierno de la Comunidad de Madrid, la International Sweeteners Association y el CIBER de Fisiopatología de la Obesidad y la Nutrición del Instituto de Salud Carlos III, analizaron el estado actual del conocimiento científico en torno a los Edulcorantes sin y bajos en calorías (ESBC) y desarrollaron un Decálogo sobre su uso que constituye la Declaración de Chinchón. Los edulcorantes, incluido el azúcar, constituyen un elemento de indudable interés y actualidad, aunque no exento de desconocimiento por algunos sectores tanto académicos como de la población en general. La propia naturaleza de los ESBC los hace susceptibles de informaciones tergiversadas e incluso contradictorias. Son aditivos alimentarios ampliamente utilizados como sustitutivos del azúcar para endulzar alimentos, medicamentos y complementos alimenticios cuando se persiguen fines no nutritivos. El Decálogo de Chinchón es fruto de una reunión de reflexión y consenso por parte de un grupo de expertos procedentes de distintas disciplinas científicas (toxicología, nutrición clínica, nutrición comunitaria, fisiología, bromatología, salud pública, atención primaria, pediatría, endocrinología y nutrición, enfermería, atención farmacéutica y legislación alimentaria). El decálogo incluye diferentes aspectos de los EBSC relacionados con la legislación, uso, beneficios y seguridad. En general, los beneficios de los EBSC han sido tradicionalmente desatendidos en comparación con la tendencia de destacar posibles riesgos inexistentes o que no han sido probados. Hace especial hincapié en la necesidad de fortalecer la investigación de los EBSC en España, así como la necesidad de formar en este ámbito a los profesionales y a los consumidores en general.
Assuntos
Edulcorantes , Peso Corporal , Inquéritos de Saúde Bucal , História do Século XX , Humanos , Legislação sobre Alimentos , Edulcorantes/efeitos adversos , Edulcorantes/história , Paladar/fisiologiaRESUMO
Medical emergencies in the dentist's office are a primary concern for dental surgeons. Since each individual therapist is personally responsible for the management of those eventualities, they must be properly trained to handle them. Prevention is still the most effective method for avoiding them, with clinical examination as the prime basis for their management. Some current factors that increase the possibility of office emergencies include: a raise in life expectancy rates, thus increasing the number of patients with chronic diseases; multiple and complex therapeutic regimes; patients under dialysis, immunosuppression, transplants, etc. Apart from proper training of the dental surgeon in managing medical emergencies, he must have adequate equipment for treating such events. This article aims to offer dentists a practical guide to emergency equipment, which must always be at his immediate disposal, as well as some practical guidelines for the use of drugs and some recommendations regarding the organization of such equipment.
Assuntos
Consultórios Odontológicos , Emergências , Primeiros Socorros/instrumentação , Albuterol , Aminofilina , Clorfeniramina , Diazepam , Epinefrina , Glucose , Humanos , Hidrocortisona , IsossorbidaRESUMO
Para un estado óptimo de salud se requiere de un buen equilibrio de la condición oral. Una dieta balanceada comprende alimentos saludables y diversos, lo cual es clave para mantener un buen estado de salud bucodental, debería tomarse en consideración ellimitar el exceso de carbohidratos en las comidas. La dieta afecta la salud oral de muchas maneras como la generación de caries dental, defectos en el desarrollo del esmalte, erosión dental y enfermedad periodontal y esta situación podría afectar la salud general dando como resultado la aparición de enfermedades cardiovasculares o infecciosas, entre otras.
For an optimal health a good oral equilibrium is required. A balanced diet comprising of diverse and healthy foods is key to promoting good oral health, limitation of high carbohydrates intake should be taken into consideration. Diet affects oral health in many ways such as diet include dental caries, developmental defects of enamel, dental erosion and periodontal disease and this situation could affect general health in many ways like cardiovascular and infectious diseases.
Assuntos
Humanos , Dieta , Saúde Bucal , Cárie Dentária/etiologia , Cárie Dentária/prevenção & controle , Doenças Periodontais/complicações , Fatores de Risco , Sacarose Alimentar/efeitos adversosRESUMO
Las urgencias médicas en el consultorio dental son una preocupación para el cirujano dentista. Cada profesional es responsable del manejo de estas eventualidades, por lo que debe estar entrenado para afrontarlas. La prevención es el medio más eficaz para evitarlas, y el examen clínico constituye la base de su manejo. Algunos factores que incrementan la posiblidad de urgencias en la actualidad incluyen aumento en el promedio de vida, lo cual aumenta el número de pacientes con enfermedades crónicas, esquemas terapéuticos múltiples y complejos, pacientes sometidos a diálisis, inmunosupresión, trasplante, etc. Además del adiestramiento del cirujano dentista en el manejo de urgencias médicas, éste debe contar con un equipo que le permita enfrentar estas situaciones. El objetivo de este artículo es ofrecer al cirujano dentista una guía acerca del equipo con el cual debe contar en su consultorio, así como lineamientos en el uso de fármacos y recomendaciones para organizar el equipo