WWOM VII: Effectiveness of topical interventions in the management of burning mouth syndrome: A systematic review.

OBJECTIVES: To assess the effectiveness of topical interventions in the management of burning mouth syndrome (BMS), based on the core outcome domains recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT). METHODS: A systematic literature review of RCTs on topical interventions for the management of BMS, published in PubMed, Web of Science, PsycInfo, Cochrane Database/Central, and Google Scholar through May 2021 was performed. RESULTS: Eight RCTs (n = 358 study participants) were included in this study. Due to underreporting of IMMPACT domains, publication bias, high degree of heterogeneity between studies, meta-analysis was not undertaken. Based on changes in visual analogue pain scores (ΔVAS), the most reported outcome, the effectiveness of the topical interventions was demonstrated; however, it is low level of evidence. CONCLUSIONS: High levels of variability (interventions, outcomes, outcome measurement tools, and intervention effects evaluated), heterogeneity, publication bias, and underreporting of IMMPACT domains were observed across the RCTs. This systematic review highlights the need for application of standardized outcome measures to future RCTs. At the present time, there is lack of moderate-strong evidence on short- and long-term outcomes to support or refute the use of any particular topical intervention in managing BMS. Future RCTs with standardized outcome measures are needed.

World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.

OBJECTIVE: To detail a scoping review on the global and regional relative frequencies of oral mucosal disorders in the children based on both clinical studies and those reported from biopsy records. MATERIALS AND METHODS: A literature search was completed from 1 January 1990 to 31 December 2018 using PubMed and EMBASE. RESULTS: Twenty clinical studies (sample size: 85,976) and 34 studies from biopsy services (40,522 biopsies) were included. Clinically, the most frequent conditions were aphthous ulcerations (1.82%), trauma-associated lesions (1.33%) and herpes simplex virus (HSV)-associated lesions (1.33%). Overall, the most commonly biopsied lesions were mucoceles (17.12%), fibrous lesions (9.06%) and pyogenic granuloma (4.87%). By WHO geographic region, the pooled relative frequencies of the most common oral lesions were similar between regions in both clinical and biopsy studies. Across regions, geographic tongue (migratory glossitis), HSV lesions, fissured tongue and trauma-associated ulcers were the most commonly reported paediatric oral mucosal lesions in clinical studies, while mucoceles, fibrous lesions and pyogenic granuloma were the most commonly biopsied lesions. CONCLUSIONS: The scoping review suggests data from the clinical studies and biopsy records shared similarities in the most commonly observed mucosal lesions in children across regions. In addition, the majority of lesions were benign in nature.

Eco-friendly profile of pegylated nano-graphene oxide at different levels of an aquatic trophic chain.

Nanographene oxide (nGO) has been recently proposed as a new antitumoral therapeutic agent, drug delivery carrier and gene transfection vehicle, among others. Treatment is carried out by hyperthermia induced by infrared irradiation. After treatment, the nanosystems will be inevitably excreted and released to the environment. To understand the potential impacts of pegylated nGO (nGO-PEG), three key species from different trophic levels were used: the green micro-algae Raphidocelis subcapitata (growth inhibition test), the cladocera Daphnia magna (acute and chronic tests), and the fish Danio rerio (fish embryo test). Besides a regular standard procedure to assess toxicity, and considering the mode of action of nGO-PEG in cancer treatment, a simultaneous infrared lamp exposure was carried out for D. magna and D. rerio. Additionally, and taking advantage of the phenotypic transparency of D. magna, nGO-PEG was fluorescently tagged to evaluate the potential uptake of nGO-PEG. The R. subcapitata growth inhibition test showed effects during the first 48 h, recovering till the end of the test (96 h). No acute or chronic effects were observed for D. magna, under standard or infrared light exposures although confocal microscope images showed nGO-PEG uptake. Very small percentages of mortality and abnormalities were observed in D. rerio exposed with and without the infrared lamp. Although low hazard may be expected for nGO-PEG in aquatic ecosystems, further studies with species with different life traits should be accomplished, in order to derive more accurate conclusions.

Planejamento em Implantodontia: uma visão contemporânea / Treatment planning in implantodontology: a contemporary view

O implante osseointegrável oferece a possibilidade de reabilitação protética do sistema estomatognático, permitindo o restabelecimento da função, estética e fonética adequadas, além de devolver ao paciente sua autoestima. Quando se pensa na reabilitação bucal com implantes, um aspecto marcante que não poderá seresquecido pelo profissional é que a sua posição é imutável, pois, depois de realizado o implante, muitas vezes, pode se impossibilitar o tratamento reabilitador. O tratamento reabilitador, através de implantes, deve ter início com a construção de próteses diagnósticas, quando o profissional poderá antever o resultado final, em que juntamente com os exames complementares, serão percebidas, observadas, evidenciadas a quantidade e aqualidade de tecido mole e tecido ósseo bem como a necessidade de modificações para atender o planejamentoprévio estabelecido pela prótese diagnóstica que foi transformada em guia ou gabarito cirúrgico, otimizando, assim, o resultado final do tratamento respeitando a posição, número e inclinação dos implantes. Conclui-se que a reabilitação oral, através de implantes, desde as mais simples às mais complexas, num contexto atual de excelência clínica, envolve a íntima relação de várias especialidades odontológicas, que devem estar em sintonia e participar ativamente no diagnóstico, planejamento e execução de cada caso.

Realidade odontológica do indivíduo da terceira idade / Dental reality of aged people

O objetivo deste trabalho foi avaliar aspectos pessoais, hábitos de freqüentar o dentista, freqüência e técnica de escovação entre os indivíduos da terceira idade atendidos no Serviço de Geriatria do Hospital Universitário Osvaldo Cruz, para tanto foram selecionados aleatoriamente 50 pacientes. Na metodologia empregada, utilizou-se entrevista associada ao exame clínico da cavidade oral. Através da análise Estatística Descritiva (média de tendência central, dispersão e proporção) das informações, observou-se que a média de idade foi 70,4 anos, sendo 56 por cento do gênero masculino e 44 por cento do gênero feminino; 85,7 por cento não tinham hábito de ir ao dentista; 75 por cento eram edentados totais, desses 56 por cento usavam prótese total, sendo que 42,9 por cento usavam apenas a prótese superior; 45 por cento faziam escovação duas vezes ao dia e desses apenas 16 por cento escovavam a língua; apenas 25 por cento apresentavam dentes naturais, fazendo-se uma média de 8 dentes por indivíduo, sendo que o maior número de dentes encontrava-se na arcada inferior e apenas 30 por cento na arcada superior. Concluindo-se que há necessidade do fortalecimento da conscientização e valorização por parte do idoso para freqüentar com periodicidade o cirurgião-dentista, como parte de um programa de saúde geral