Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
1.
Int J Paediatr Dent ; 22(3): 169-79, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-21999806

RESUMO

BACKGROUND: Mexican-American children have a higher caries prevalence than the U.S. average. The Mothers and Youth Access (MAYA) study was a randomized clinical trial initiated to address this problem. AIM: Comparison of the efficacy of two prevention interventions in reducing early childhood caries (ECC). DESIGN: All 361 randomized mother-child dyads received oral health counselling. Beginning at 4 months postpartum, intervention mothers received chlorhexidine (CHX) mouthrinse for 3 months beginning 4 months postpartum and children received fluoride varnish (FV) every 6 months from age 12-36 months. Control group children received FV if precavitated lesions developed. Salivary mutans streptococci (MS) and lactobacilli were assessed. RESULTS: No significant difference in children's 36-month caries incidence between groups; 34% in each group developed caries [(d(2+) fs) > 0]. About half of control group developed precavitated lesions and received therapeutic FV. Maternal MS levels declined during CHX use, but increased when discontinued. CONCLUSIONS: Maternal postpartum CHX regimen, oral health counselling and preventive child FV applications were not more efficacious than maternal counselling with child therapeutic FV for precavitated lesions for ECC prevention. FV for young children with brief maternal CHX use and oral health counselling may need to be combined with additional or longer-term therapies to significantly reduce ECC in high-risk populations.


Assuntos
Anti-Infecciosos Locais/uso terapêutico , Cariostáticos/uso terapêutico , Clorexidina/uso terapêutico , Aconselhamento , Cárie Dentária/prevenção & controle , Fluoretos Tópicos/uso terapêutico , Antissépticos Bucais/uso terapêutico , Adolescente , Adulto , Carga Bacteriana/efeitos dos fármacos , California , Pré-Escolar , Índice CPO , Feminino , Seguimentos , Humanos , Lactente , Lactobacillus/efeitos dos fármacos , Lactobacillus/isolamento & purificação , Americanos Mexicanos , Saliva/microbiologia , Streptococcus mutans/efeitos dos fármacos , Streptococcus mutans/isolamento & purificação , Streptococcus sobrinus/efeitos dos fármacos , Streptococcus sobrinus/isolamento & purificação , Resultado do Tratamento , Adulto Jovem
2.
Clin Trials ; 5(4): 336-46, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18697848

RESUMO

BACKGROUND: Recruitment and retention in clinical trials of minorities is low, particularly in rural underserved populations. This has slowed progress in addressing racial/ethnic disparities in oral health. PURPOSE: To describe factors associated with successful recruitment, and identify predictors of continued retention of pregnant women attending a community health center into a randomized controlled clinical trial to prevent early childhood caries. METHODS: The Mothers and Youth Access (MAYA) Trial recruited women in the second trimester of pregnancy. At baseline, consenting women completed an oral health questionnaire and received a dental exam and oral health counseling. Four months postpartum, women returned with their babies for randomization with follow up at 9-, 12-, 18-, 24-, 30-, and 36-month postpartum visits. To assess predictors of retention, data about respondents' demographics, and oral health-related knowledge, attitudes, and behaviors were obtained by questionnaire and analyzed by logistic and discrete time-to-event regression analyses. RESULTS: Of 556 predominantly Mexican-American women recruited at baseline, 195 (35%) were excluded after baseline for not meeting inclusion criteria; 361 (65%) continued to randomization. Factors such as race/ethnicity, annual household income, household composition, oral health-related knowledge and behaviors significantly related to retention until randomization. In multivariable models, women reporting a higher annual household income were less likely to be lost to attrition before randomization (odds ratio = 0.73, 95% confidence interval (CI) 0.60-0.89); while Mexican/Mexican-American women were less likely to be lost beyond randomization (hazard ratio = 0.53, 95% CI 0.26-1.08). LIMITATIONS: Factors not measured at baseline may have been important in predicting attrition. The MAYA Trial is expected to finish by November 2008; therefore, complete results for total retention may differ from those reported here. CONCLUSIONS: Recruitment and retention efforts for pregnant Hispanic women should place heavy emphasis on culture as ethnicity remained the only borderline significant predictor in postrandomization retention.


Assuntos
Centros Comunitários de Saúde , Americanos Mexicanos/estatística & dados numéricos , Seleção de Pacientes , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Serviços de Saúde Rural , Adolescente , Adulto , Pré-Escolar , Características Culturais , Coleta de Dados , Demografia , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Lactente , Recém-Nascido , Gravidez , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA