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Nat Prod Res ; 29(15): 1406-13, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25605432

RESUMO

A new myrsinol-type diterpene polyester, 14-deoxo-3ß-O-propinoyl-2α,5α,7ß,15ß-tetra-O-acetyl-14α-O-benzoyl-myrsinol (1), and its known analogue, 14-deoxo-3ß-O-prorionyl-5α,15ß-di-O-acetyl-7ß-O-nicotinoyl-myrsinol-14ß-acetate (2), together with a monoterpenoid, pubinernoid A (3), two indole alkaloids, neoechinulin A (4) and dihydroxyisoechinulin A (5), two benzene derivatives, siringin (6) and (3-methoxyphenyl) acetic acid (7), were isolated from the 70% acetone extract of the aerial parts of Euphorbia dracunculoides Lam. Their structures were elucidated on the basis of spectroscopic evidence and comparison with literature reports. The absolute configuration of 1 was deduced by comparing experimental and calculated ECD spectra. Among them, compounds 4 and 5 were first obtained from the plant source. In addition, the (13)C NMR data of compound 2 was reported for the first time.


Assuntos
Diterpenos/química , Euphorbia/química , Componentes Aéreos da Planta/química , Poliésteres/química , Linhagem Celular Tumoral/efeitos dos fármacos , Diterpenos/isolamento & purificação , Humanos , Estrutura Molecular , Poliésteres/isolamento & purificação
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