RESUMO
Diabetes mellitus (DM) is a well known complication of interferon therapy for chronic hepatitis C virus (HCV) infection, but resolution of interferon-induced DM was rarely reported. In HIV and HCV co-infected patients, only two cases of incident DM during interferon therapy were reported and both cases required permanent insulin treatment. We report the first case of HIV/HCV co-infected patient who developed diabetic ketoacidosis during treatment for chronic HCV infection with complete resolution of DM after treatment cessation. Review of reported cases indicates that pancreatic autoantibodies and human leukocyte antigen haplotypes may predict the outcome of interferon-induced diabetes.
Assuntos
Antivirais/efeitos adversos , Diabetes Mellitus Tipo 2/induzido quimicamente , Infecções por HIV/complicações , HIV-1 , Hepatite C Crônica/tratamento farmacológico , Interferon-alfa/efeitos adversos , Polietilenoglicóis/efeitos adversos , Adulto , Autoanticorpos/sangue , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/imunologia , Antígenos HLA-D/genética , Haplótipos , Hepatite C Crônica/complicações , Humanos , Interferon alfa-2 , Masculino , Pâncreas/imunologia , Proteínas Recombinantes , Remissão EspontâneaRESUMO
Brain abscesses are occasionally associated with a dental source of infection. An unusual case of frontal lobe abscess in a nonimmunocompromised child infected with multidrug-resistant Capnocytophaga ochracea is described and confirms the pathogenic potential of this organism to cause human disease in the central nervous system.
Assuntos
Abscesso Encefálico/microbiologia , Capnocytophaga/isolamento & purificação , Farmacorresistência Bacteriana Múltipla , Lobo Frontal/microbiologia , Infecções por Bactérias Gram-Negativas/microbiologia , Antibacterianos/farmacologia , Abscesso Encefálico/diagnóstico por imagem , Capnocytophaga/classificação , Capnocytophaga/efeitos dos fármacos , Capnocytophaga/genética , Criança , Lobo Frontal/diagnóstico por imagem , Infecções por Bactérias Gram-Negativas/diagnóstico por imagem , Humanos , Masculino , Testes de Sensibilidade Microbiana , RadiografiaRESUMO
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 x 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis.