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J Nanosci Nanotechnol ; 18(4): 2294-2303, 2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29442895

RESUMO

This paper presents the results of zeta potential, water contact angle, atomic force microscopy image, in vitro solubility, and content of heavy metals in polylactic acid (PLA)/chitosan (CS) nanoparticles loading nifedipine. In addition, the In Vivo test of the PLA/CS nanoparticles loading nifedipine in the mice is also one of highlights of this work. The Zeta potential result shows that the charged surface of the PLA/CS nanoparticles loading nifedipine is neutral, negative or complex depending on nifedipine content. Nifedipine plays a role in increase of hydrophobic property, swelling degree and regular surface as well as decrease of surface rough of the nanoparticles. The PLA/CS/nifedipine nanoparticles are dissolved in the solutions with pH 6.8, pH 4.5 and pH 1.2. The In Vivo test of PLA/CS nanoparticles loading nifedipine on mice was evaluated by the change in diastolic pressure, systolic pressure, arterial pressure and heart rate. The obtained results confirm that the PLA/CS nanoparticles loading nifedipine is suitable to apply in the treatment of hypertension patients lately.


Assuntos
Bloqueadores dos Canais de Cálcio/administração & dosagem , Quitosana/química , Nanopartículas , Nifedipino/administração & dosagem , Poliésteres/química , Animais , Bloqueadores dos Canais de Cálcio/farmacocinética , Humanos , Camundongos , Nifedipino/farmacocinética , Polímeros
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