RESUMO
Crohn's disease can involve any part of the gastrointestinal tract. Although good conservative treatment is given as soon as possible, most patients with this disease will eventually require surgery. We encountered a case of Crohn's disease associated with anemia which we treated with laparoscopic-assisted ileectomy. The postoperative course was satisfactory. The most important characteristic of Crohn's disease, fat wrapping and extending over the serosal surface toward the antimesenteric border, was observed in the ileum, distinguishing the disease and pinpointing the lesion accurately. This surgical method has an advantage over open surgery in that the recovery time is shorter and incisions are smaller, allowing easier surgery in the future, shortening the patient's hospital stay, and improving the patient's quality of life.
Assuntos
Anemia/cirurgia , Doença de Crohn/cirurgia , Hemorragia Gastrointestinal/cirurgia , Íleo/cirurgia , Laparoscopia , Adulto , Anemia/sangue , Anemia/patologia , Doença Crônica , Doenças do Colo/sangue , Doenças do Colo/patologia , Doenças do Colo/cirurgia , Colonoscopia , Doença de Crohn/sangue , Doença de Crohn/patologia , Diagnóstico Diferencial , Hemorragia Gastrointestinal/sangue , Hemorragia Gastrointestinal/patologia , Granuloma de Células Gigantes/sangue , Granuloma de Células Gigantes/patologia , Granuloma de Células Gigantes/cirurgia , Humanos , Íleo/patologia , Obstrução Intestinal/sangue , Obstrução Intestinal/patologia , Obstrução Intestinal/cirurgia , Tempo de Internação , Masculino , Qualidade de Vida , Fatores de RiscoRESUMO
Blood group-related glycans determining ABO and Lewis blood groups are known to function as attachment factors for most of the norovirus (NoV) strains. To identify binding specificity of each NoV, recombinant norovirus-like particles (VLPs) and human saliva samples with different ABO, Lewis phenotypes and secretor status have been commonly applied. When binding specificities of VLPs prepared from 16 different genotypes of NoVs in GI and GII genogroups were characterized in samples of human gastric mucosa compared to human saliva based on blood group phenotypes, considerable differences were observed for several strains. Novel binding specificities determined by an ELISA using preparations from human gastric mucosa were also ascertained by immunohistochemical analyses using human jejunal mucosa, widely believed to be susceptible to NoV infection. Further, A, B and O(H) blood group substances prepared from porcine and squid tissues were found to be effective for preventing ABO blood group-specific binding of VLPs to both saliva and mucosa samples. Therefore, these blood group substances might have potential for the prevention and treatment of NoV infection.