Optical interconnection for a polymeric PLC device using simple positional alignment.

This study proposes a simple cost-effective method of optical interconnection between a planar lightwave circuit (PLC) device chip and an optical fiber. It was conducted to minimize and overcome the coupling loss caused by lateral offset which is due to the process tolerance and the dimensional limitation existing between PLC device chips and fiber array blocks with groove structures. A PLC device chip and a fiber array block were simultaneously fabricated in a series of polymer replication processes using the original master. The dimensions (i.e., width and thickness) of the under-clad of the PLC device chip were identical to those of the fiber array block. The PLC device chip and optical fiber were aligned by simple positional control for the vertical direction of the PLC device chip under a particular condition. The insertion loss of the proposed 1 x 2 multimode optical splitter device interconnection was 4.0 dB at 850 nm and the coupling loss was below 0.1 dB compared with single-fiber based active alignment.

Nanostructured multifunctional surface with antireflective and antimicrobial characteristics.

Functional polymeric films with antireflective and hydrophobic properties have been widely used for electronic device displays. However, the design of such functional films with an antimicrobial characteristic has been a challenge. We designed a nanostructured surface using a rigorous coupled-wave analysis to obtain a period of 300 nm and an aspect ratio of 3.0 on a flat poly(methyl methacrylate) film. The fabricated nanostructure was hydrophobic and exhibited the desired optical characteristics with a reflectance of less than 0.5% over the visible wavelength range. Furthermore, the nanoimprinted polymer film exhibited antimicrobial characteristics and low adhesion when compared with the corresponding flat surface. The results suggest that the nanostructured surface designed in this study is multifunctional and should be suitable for the production of protective optical and hygienic polymer films for the displays of portable electronic devices.

In line NIR quantification of film thickness on pharmaceutical pellets during a fluid bed coating process.

Along with the risk-based approach, process analytical technology (PAT) has emerged as one of the key elements to fully implement QbD (quality-by-design). Near-infrared (NIR) spectroscopy has been extensively applied as an in-line/on-line analytical tool in biomedical and chemical industries. In this study, the film thickness on pharmaceutical pellets was examined for quantification using in-line NIR spectroscopy during a fluid-bed coating process. A precise monitoring of coating thickness and its prediction with a suitable control strategy is crucial to the quality assurance of solid dosage forms including dissolution characteristics. Pellets of a test formulation were manufactured and coated in a fluid-bed by spraying a hydroxypropyl methylcellulose (HPMC) coating solution. NIR spectra were acquired via a fiber-optic probe during the coating process, followed by multivariate analysis utilizing partial least squares (PLS) calibration models. The actual coating thickness of pellets was measured by two separate methods, confocal laser scanning microscopy (CLSM) and laser diffraction particle size analysis (LD-PSA). Both characterization methods gave superb correlation results, and all determination coefficient (R(2)) values exceeded 0.995. In addition, a prediction coating experiment for 70min demonstrated that the end-point can be accurately designated via NIR in-line monitoring with appropriate calibration models. In conclusion, our approach combining in-line NIR monitoring with CLSM and LD-PSA can be applied as an effective PAT tool for fluid-bed pellet coating processes.