RESUMO
We describe the case of 26-year-old patient who is apprehensive for any possible sequelae of the deeply impacted teeth. This case shows that separation of the buccal plate can have availability to remove deeply impacted molars with less any possible complications than those of sagittal split osteotomy.
Assuntos
Mandíbula/cirurgia , Dente Molar/cirurgia , Dente Impactado/cirurgia , Adulto , Humanos , Mandíbula/diagnóstico por imagem , Dente Molar/diagnóstico por imagem , Osteotomia/métodos , Radiografia , Dente Impactado/diagnóstico por imagemRESUMO
We performed 114 consecutive primary total hip arthroplasties with a cementless expansion acetabular component in 101 patients for advanced osteonecrosis of the femoral head. The mean age of the patients at surgery was 51 years (36 to 62) and the mean length of follow-up was 110 months (84 to 129). The mean pre-operative Harris hip score of 47 points improved to 93 points at final follow-up. The polyethylene liner was exchanged in two hips during this period and one broken acetabular component was revised. The mean linear wear rate of polyethylene was 0.07 mm/year and peri-acetabular osteolysis was seen in two hips (1.9%). Kaplan-Meier analysis indicated that the survival of the acetabular component without revision was 97.8% (95% confidence interval 0.956 to 1.000) at ten years. Our study has shown that the results of THA with a cementless expansion acetabular component and an alumina-polyethylene bearing surface are good.
Assuntos
Artroplastia de Quadril/métodos , Necrose da Cabeça do Fêmur/cirurgia , Prótese de Quadril , Acetábulo , Adulto , Óxido de Alumínio , Cimentos Ósseos , Feminino , Seguimentos , Articulação do Quadril/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Polietileno , Complicações Pós-Operatórias/diagnóstico por imagem , Desenho de Prótese , Falha de Prótese , Radiografia , Resultado do TratamentoRESUMO
Healthy bone is maintained by the coordinated activities of osteoblast-mediated bone formation and osteoclast-dependent bone resorption. Pathologic conditions such as hormonal imbalance and inflammation cause increased osteoclastogenesis resulting in osteoporosis, rheumatoid arthritis, and periodontitis. Bortezomib is novel antimyeloma agent that has a direct beneficial effect on bone formation. However, the role of bortezomib in osteoclastogenesis and underlying mechanisms remains to be fully comprehended. In the present study, we show that bortezomib directly inhibited the receptor activator of nuclear factor κB ligand (RANKL)- and lipopolysaccharide-dependent osteoclast differentiation. Interestingly, the bortezomib-mediated inhibition of osteoclastogenesis was transient, since the removal of bortezomib from culture completely restored osteoclast differentiation. Bortezomib impeded the induction and nuclear localization of nuclear factor of activated T cells, cytoplasmic 1 and reduced both macrophage colony-stimulating factor- and RANKL-induced extracellular-signal-regulated kinase (ERK) phosphorylation. In a mouse model of periodontitis, bortezomib prevented alveolar bone erosion induced by Porphyromonas gingivalis lipopolysaccharide. These data not only suggest a previously unappreciated mechanism by which bortezomib regulates bone resorption but also propose novel applications of bortezomib beyond its use as an antimyeloma agent.
Assuntos
Processo Alveolar/efeitos dos fármacos , Antineoplásicos/farmacologia , Ácidos Borônicos/farmacologia , Lipopolissacarídeos/farmacologia , Osteoclastos/efeitos dos fármacos , Porphyromonas gingivalis/efeitos dos fármacos , Pirazinas/farmacologia , Animais , Bortezomib , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Porphyromonas gingivalis/patogenicidadeRESUMO
The effects of the C-value (bonded surface area/unbonded surface area) and the volume of the cavity on the volumetric dimensional changes [volumetric setting shrinkage (VSS) and volumetric hygroscopic expansion (VHE)] of a resin-modified glass-ionomer (RMGI) filled in experimental cylindrical cavities were evaluated. The VSS and the VHE rate decreased with increasing C-value. There was a high inverse regression between the cavity C-value and volumetric dimensional changes, but a low regression between cavity volume and volumetric dimensional changes. Therefore, it was thought that greater contraction stress would remain in high C-value cavities than low C-value cavities during the setting process. It was also confirmed that the volumetric dimensional changes of RMGI in cavity were influenced primarily by the cavity C-value.
Assuntos
Colagem Dentária , Adaptação Marginal Dentária , Cimentos de Ionômeros de Vidro/química , Resinas Sintéticas/química , Absorção , Animais , Bovinos , Fenômenos Químicos , Físico-Química , Preparo da Cavidade Dentária , Teste de Materiais , Polímeros/química , Água/químicaRESUMO
PURPOSE: This study investigated the effect of mandibular setback surgery on occlusal force and evaluated the extent to which postsurgical changes in such force can be explained by the type of operation, the duration of maxillo-mandibular fixation (MMF), and the changes in the mechanical advantage of the jaw musculature. MATERIALS AND METHODS: Maximal molar bite force was measured before surgery and at MMF removal, and 3, 6, and 12 months thereafter in 26 patients with mandibular prognothism. To correlate bite force and skeletal change, the cephalometric tracings were measured, tabulated, and statistically analyzed. RESULTS: Mean bite force was 13.7 kg before surgery, 7.6 kg at MMF removal, 14.2 kg at 3 months, 19.7 kg at 6 months, and 26.1 kg at 12 months post-surgery. The bite force was positively correlated with the surgical change in mandibular plane angle and mandibular body length. The recovery of bite force was significantly affected by the type of operation and duration of MMF. CONCLUSIONS: To hasten recovery and increase bite force after orthognathic surgery, long periods of MMF and injury to the masticatory muscles should be avoided.
Assuntos
Força de Mordida , Técnicas de Fixação da Arcada Osseodentária/efeitos adversos , Mandíbula/cirurgia , Osteotomia/métodos , Prognatismo/cirurgia , Adolescente , Adulto , Análise de Variância , Cefalometria , Feminino , Humanos , Imobilização/efeitos adversos , Masculino , Mandíbula/anormalidades , Osteotomia/efeitos adversos , Fatores Sexuais , Estatísticas não ParamétricasRESUMO
The optimum fermentation conditions for the production of cellulose by a newly isolated Acetobacter sp. A9 were determined by shaken cultures. The strain was able to produce cellulose at 25-30 degrees C with a maximum at 30 degrees C. Cellulose production occurred at pH 4.5-7.5 with a maximum at pH 6.5. The improved medium composition was 4% (w/v) glucose, 0.1% (w/v) yeast extract, 0.7% (w/v) polypeptone and 0.8% (w/v) Na(2)HPO(4).12H(2)O. Under these culture conditions, 3.8 g/l cellulose was produced after 7 days of cultivation, although this strain produced only 2.2 g/l in the standard medium. The addition of ethanol to the improved medium enhanced cellulose production: in an improved medium containing 1.4% (v/v) ethanol, cellulose production was 15.2 g/l, which was about four times higher than that without ethanol. Addition of ethanol was found to eliminate the spontaneous mutation of Acetobacter sp. A9.