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1.
Intern Med ; 61(14): 2209-2213, 2022 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-34980800

RESUMO

Pure red cell aplasia (PRCA) associated with erythropoiesis-stimulating agents (ESAs), which were first reported in 1998, usually occurs with subcutaneous administration of epoetin alfa (Eprex®). Improvements in ESA storage, handling, and administration methods have reduced the PRCA incidence. Continuous erythropoietin receptor activator (CERA) is a third-generation ESA that is rarely reported to induce PRCA. We herein report a case of CERA-induced PRCA presenting with positive anti-erythropoietin (EPO) and anti-CERA antibodies, which was successfully treated with prednisolone. Clinicians should be aware of the possibility of antibody-mediated PRCA induced by an ESA in CKD patients with anemia with reticulocytopenia and low serum EPO levels.


Assuntos
Anemia , Hematínicos , Aplasia Pura de Série Vermelha , Anemia/etiologia , Anticorpos , Epoetina alfa/efeitos adversos , Eritropoetina , Humanos , Polietilenoglicóis , Prednisolona/uso terapêutico , Proteínas Recombinantes/efeitos adversos , Aplasia Pura de Série Vermelha/induzido quimicamente
2.
Int J Environ Res Public Health ; 11(12): 12611-22, 2014 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-25489996

RESUMO

The present cohort study examined how lifestyle, household environment, and caries activity test score of Japanese children at age 1.5 years affected their dental caries incidence at age 3. Inclusion criteria were 1.5-year-old children with no dental caries. Dental examinations were performed for 33,655 children who participated in routine dental examinations at 1.5 years of age, and the exam was repeated approximately 21 months later (at age 3) at the Kobe City Public Health Center in Japan. After excluding 622 children who had caries at age 1.5 and 1831 children with missing lifestyle and household environment data in the questionnaires, the final data analysis was performed on a total of 31,202 children (16,052 boys, 15,150 girls).The multivariate logistic regression analysis indicated a strong association of the consumption of sugar-sweetened beverages/snacks, less frequent tooth brushing by the parents, lack of fluoride varnish, family history of smoking, with the risk of developing dental caries. A child's late bedtime is also one of the major risk factors for dental caries development. Further investigation is needed to examine whether the short duration or the irregularity of the sleep-wake cycle would affect early childhood oral health and whether there is a relationship between late bedtime and late night snack intake.


Assuntos
Cárie Dentária/epidemiologia , Características da Família , Estilo de Vida , Pré-Escolar , Cárie Dentária/etiologia , Meio Ambiente , Feminino , Humanos , Incidência , Lactente , Japão/epidemiologia , Estudos Longitudinais , Masculino
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