Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
PLoS One ; 12(10): e0187032, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29073254

RESUMO

INTRODUCTION: This study aimed to determine the effect of combining positive airway pressure (PAP) therapy and mandibular advancement device (MAD) in patients with severe obstructive sleep apnea (OSA) who were pressure intolerant for PAP and were unresponsive to MAD. METHODS: This retrospective study reviewed the medical records of severe OSA patients with apnea-hypopnea index (AHI) ≥ 30/hr who were diagnosed between October 1, 2008 and June 30, 2014. Patients were initially treated with 2 weeks of PAP, and those who were intolerant to high-pressure PAP (≥15 cm H2O) were switched to 12 weeks of MAD, which is a monobloc designed at 75% of maximum protrusion. Patients who had high residual AHI (≥15/hr) on MAD underwent 12 weeks of combination therapy (CT) with MAD and CPAP and were enrolled in the present study. Enrolled subjects who completed the 12-week CT were followed-up until June 30, 2016. RESULTS: A total of 14 male patients were included. All three treatments effectively reduced AHI, oxygen desaturation index (ODI), and total sleep time with SpO2 <90% (% TST-SpO2<90%) compared to pretreatment values. The residual AHI and ODI on CT was lower than that on MAD or PAP. The residual % TST-SpO2<90% was lower than that on MAD and similar to that on PAP. The therapeutic pressure on CT was on average 9.2 cm H2O lower than that on PAP. For the 11 patients who completed CT, only CT reduced ESS compared to pretreatment value. No treatment had significant impact on % slow wave sleep or overnight change of blood pressure. For patients who completed CT, the average usage was 5.9±1.7 hr/night at 12th week and 6.4±1.5 hr/night at a median follow-up of 36.5-months. CONCLUSIONS: Combining MAD and CPAP showed additive effects on reducing AHI and ODI, and lowered the therapeutic pressures.


Assuntos
Pressão Positiva Contínua nas Vias Aéreas , Avanço Mandibular/instrumentação , Apneia Obstrutiva do Sono/terapia , Pressão Sanguínea , Terapia Combinada , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Estudos Retrospectivos , Apneia Obstrutiva do Sono/diagnóstico por imagem , Apneia Obstrutiva do Sono/fisiopatologia , Tomografia Computadorizada por Raios X , Falha de Tratamento
2.
Dalton Trans ; 44(26): 11763-73, 2015 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-26050624

RESUMO

Previous studies on the ring-opening polymerization of ε-caprolactone using structurally related aluminum complexes as pre-catalysts showed inconsistent trends in the total conversion time. We propose that an induction period for Al complexes for conversion to real catalytic species, Al alkoxide, should be considered because the total conversion time consists of both an induction period and polymer propagation time. Herein, the polymerization rate of a series of Al complexes bearing ketimine ligands was investigated. The catalytic results indicated complexes with more steric hindrance with an electron-withdrawing group on the ligands, or the fact that less chelating ligands demonstrated greater propagation activity. The opposite trend for these structural effects was observed on the measurement of induction periods. These features on ligands of aluminum complexes are responsible for facilitating the conversion process to Al alkoxides. The overall catalytic performance should consider both the induction period and the propagation time.


Assuntos
Compostos de Alumínio/química , Caproatos/química , Lactonas/química , Poliésteres/síntese química , Polimerização , Catálise , Iminas/química , Modelos Moleculares , Nitrilas/química
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA