RESUMO
As a first step in the development of novel liver-specific contrast agents using ethosomes for computed tomography (CT) imaging applications, we entrapped iodine within ethosomes, which are phospholipid vesicular carriers containing relatively high alcohol concentrations, synthesized using several types of alcohol, such as methanol, ethanol, and propanol. The iodine containing ethosomes that were prepared using methanol showed the smallest vesicle size (392 nm) and the highest CT density (1107 HU). The incorporation of cholesterol into the ethosomal contrast agents improved the stability of the ethosomes but made the vesicle size large. The ethosomal contrast agents were taken up well by macrophage cells and showed no cellular toxicity. The results demonstrated that ethosomes containing iodine, as prepared in this study, have potential as contrast agents for applications in CT imaging.
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Meios de Contraste/síntese química , Lipossomos/síntese química , Fígado/metabolismo , Ácidos Tri-Iodobenzoicos/administração & dosagem , Animais , Etanol , Macrófagos/metabolismo , Camundongos , Microscopia Eletrônica de Transmissão , Fosfolipídeos , Tomografia Computadorizada por Raios XRESUMO
Photopolymerization kinetics affects the curing time, degree of conversion, polymerization shrinkage, and mechanical properties of composites. The aim of this study was to compare three methods (temperature, heat flow, and polymerization shrinkage) for photopolymerization kinetics measurement of composites. The photopolymerization kinetics of four composites (2 packable and 2 flowable) were measured with an LED light for 20 s (radiant emittance: 2,100 mW/cm2). For the two packable composites, photopolymerization kinetics was measured with varying the radiant emittance and exposure time. For each measurement method, peak times were determined as the time when maximum temperature rise, heat flow, and shrinkage rate occurred, respectively. The photopolymerization kinetics differed among the measurement methods. The photopolymerization kinetics of composites changed as the radiant emittance and composite type varied. In clinical practice and research on the composite restoration, the kinetics should be considered comprehensively with the complementary use of various measurement methods.
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Resinas Compostas , Temperatura Alta , Temperatura , Cinética , Polimerização , Teste de MateriaisRESUMO
BACKGROUND: In 2016 we reported promising midterm outcomes of bicuspid pulmonary valve replacement using 0.1-mm polytetrafluoroethylene (PTFE) membrane. This follow-up study analyzes long-term outcomes and risk factors for reintervention and structural valve deterioration (SVD). METHODS: We performed a retrospective review of the original 119 patients who underwent PTFE bicuspid pulmonary valve replacement. Median patient age was 16.9 years (range, 0.4-57.1). Reintervention was defined as any surgical or percutaneous catheter procedure on the PTFE valve. SVD was defined as development of a peak pressure gradient ≥ 50 mm Hg or at least a moderate amount of pulmonary regurgitation on follow-up echocardiography. RESULTS: The median follow-up duration was 9.5 years. The survival rate was 96.5% at 5 and 10 years, with 2 early and 2 late mortalities. Freedom from reintervention was 90.0% at 5 years and 63.3% at 10 years. Freedom from SVD was 92.8% at 5 years and 51.1% at 10 years, with regurgitation the predominant mode (64.6%). Freedom from both reintervention and SVD at 5 and 10 years were 89.1% and 49.5%, respectively. Multivariable analysis identified smaller valve diameter (hazard ratio, 0.82; P < .001) and more than trivial pulmonary regurgitation at discharge (hazard ratio, 5.81; P < .001) as risk factors for reintervention or SVD. CONCLUSIONS: Long-term results of the PTFE bicuspid pulmonary valve replacement were acceptable. However, improvements may be needed to reduce technical error and improve durability. Smaller valve diameter and more than trivial pulmonary regurgitation at discharge were risk factors for reintervention or SVD, warranting careful follow-up for timely reintervention.
Assuntos
Implante de Prótese de Valva Cardíaca , Próteses Valvulares Cardíacas , Insuficiência da Valva Pulmonar , Valva Pulmonar , Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Valva Pulmonar/cirurgia , Seguimentos , Insuficiência da Valva Pulmonar/cirurgia , Politetrafluoretileno , Implante de Prótese de Valva Cardíaca/métodos , Estudos Retrospectivos , Resultado do Tratamento , Valva Aórtica/cirurgiaRESUMO
AIM: This study aimed to identify the optimal toothpaste for removing coffee-induced stains while also evaluating its impact on tooth enamel through roughness and abraded depth parameters, providing a comprehensive understanding of their effects. MATERIALS AND METHODS: Three whitening toothpastes and 2 conventional toothpastes were prepared for a simulated brushing procedure on coffee-stained bovine enamel tooth specimens. Using a toothbrushing machine, up to 10,000 brushstrokes were completed, while spectrophotometric readings were taken at designated intervals. A mixed-effects model for statistical analysis determined the effects of toothpaste and brushing on colour change, roughness, and abraded depth. RESULTS: Whitening toothpastes significantly deviated from the control (P < .001, P < .001, and P < .003, respectively), whereas the conventional toothpaste did not exhibit a significant contrast (P < .081). Regarding colour restoration following coffee staining, whitening toothpastes showed higher restoration than conventional toothpastes. Surface roughness and abraded depth parameters increased with accumulated brushing. CONCLUSIONS: Sodium hexametaphosphate-containing toothpaste demonstrated the highest efficacy in removing coffee-induced stains and restoring tooth colour. Nevertheless, this stronger whitening effect was associated with increased abrasion. While conventional toothpastes exhibited some whitening effects, the most substantial improvement in lightness was consistently observed with whitening toothpastes. CLINICAL RELEVANCE: Understanding how whitening toothpaste affects enamel integrity is crucial for refining formulations and advancing dental care. This knowledge lays the groundwork for more effective oral care products and improved whitening procedures, ultimately enhancing the overall quality of dental treatments.
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This study investigated the effect of translucency and absorbance of conventional (FiltekTM-Z350-XT) and bulk-fill (Tetric®-N-Ceram) composites on temperature change during photopolymerization, using a non-contact infrared sensor. Three shades from each composite were selected to prepare disk-shaped specimens (n=3), which then photopolymerized with LED-light for 20 s. A second light exposure was performed on the photopolymerized specimens. The first peak temperature rise during composite photopolymerization (ΔTtotal), second peak temperature rise by the light (ΔTlight), and net peak temperature rise by composite curing heat (ΔTcomposite) were obtained from the temperature change vs. time curve. The changes in ΔTtotal and ΔTlight with varying the composite shade were greater than those in ΔTcomposite. The conventional composite showed higher ΔTtotal and ΔTlight than bulk-fill composite. ΔTtotal and ΔTlight increased as translucency parameter decreased, and absorbance increased. The potential risk for heat-induced pulpal damage should be considered when selecting a composite shade, especially for deep cavities.
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Resinas Compostas , Temperatura Alta , Temperatura , Teste de MateriaisRESUMO
In this study, a novel method for simulating human teeth was developed, with which the effect of radiant emittance of an LED curing light on the cuspal deflection was investigated. A mesio-occluso-distal (MOD) cavity was replicated using a heat-pressed ceramic and lost wax technique, and the cuspal compliance and cuspal deflection of the replicated ceramic teeth and extracted human teeth were evaluated. The replicated ceramic teeth were restored using a nano bulk-fill composite and photopolymerized using three different protocols. Data were analyzed with t-test and one-way ANOVA (α=0.05). The cuspal compliance and cuspal deflection of the replicated ceramic teeth and extracted human teeth were similar. Cuspal deflections did not differ significantly among the tested photopolymerization protocols. Thus, the replicated ceramic teeth were an effective simulation of human teeth. During bulk-fill composite restoration of the MOD cavity, cuspal deflection was not affected by changing the radiant emittance of the LED light.
Assuntos
Cárie Dentária , Infiltração Dentária , Humanos , Resinas Compostas , Restauração Dentária Permanente/métodos , Dente Pré-Molar , Preparo da Cavidade Dentária , Coroa do DenteRESUMO
This study investigated transmittance changes during photo-polymerization of composites in real-time. The transmittance changes of one conventional micro-hybrid, three conventional nano-hybrid, and four bulk-fill composites were measured before, during, and after photo-polymerization, and the maximum rate of transmittance change was compared with that of polymerization shrinkage. A significant difference in transmittance of composite between before and after photo-polymerization was observed. The transmittance of composites except for one bulk-fill composite increased during photo-polymerization. There was a correlation between the maximum rate of transmittance change and the maximum rate of polymerization shrinkage. The transmittance analysis of composites gives very important information to know for the final aesthetic restoration and allows to evaluate polymerization kinetics.
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Resinas Compostas , Estética Dentária , Polimerização , Teste de Materiais , CinéticaRESUMO
BACKGROUND/PURPOSE: Cuspal deflections in composite restoration have been investigated with considering wall compliance of human tooth cavity and light-curing protocol. The purpose of this study was to investigate effects of mold wall compliance and radiant emittance of LED light on the wall deflection of simulated aluminum mold cavities restored with a bulk-fill composite. MATERIALS AND METHODS: Sixty aluminum molds simulating a class II mesio-occluso-distal (MOD) cavity (6â¯Wâ¯×â¯8â¯Lâ¯×â¯4 D mm; W, width; L, length; D, Depth) were prepared and allocated to three groups with varying mold wall thicknesses of 1, 2, and 3â¯mm. The molds were bulk-filled with a bulk-fill composite and photo-cured. Four light-curing protocols were used: three duty ratios/exposure times: 100%/20â¯s, 50%/40â¯s, or an increasing mode (0â¯ââ¯100%)/40â¯s with a pulse width modulated (PWM) LED curing light and one 20â¯s exposure time with a commercial LED light. RESULTS: Mean mold wall deflection at 2000â¯s decreased with increasing mold wall thickness (1, 2, and 3â¯mm) (pâ¯<â¯0.05). Wall deflections with 1- and 2-mm-thick molds exhibited no statistically significant differences among light-curing protocols (pâ¯>â¯0.05). However, in the 3-mm-thick mold, wall deflections with low radiant emittance were significantly lower than those with high radiant emittance (pâ¯<â¯0.05). CONCLUSION: In composite restoration of class II MOD cavities, lowering the radiant emittance of LED light can reduce the mold wall deflection only in low compliance cavities.
RESUMO
The aim was to investigate effects of compliance and radiant emittance on cuspal deflection. A mesio-occluso-distal cavity was replicated using a flowable composite and steel rods with different diameters. To investigate the effect of cuspal compliance on deflection, the replicated tooth and extracted human tooth cavities were bulk-filled with a micro-hybrid composite. The replicated cavities with 2.0-mm-diameter steel rods were restored with bulk-filling of the micro-hybrid or a nano bulk-fill composite and photo-cured with four protocols. The cuspal deflection was the highest in the replicated tooth without steel rod, followed by with 1.0-, 1.5-, and 2.0-mm steel rods, and significantly lower in the human tooth. Cuspal deflections showed no significant differences among light-curing protocols, and that in the micro-hybrid composite were higher than the nano bulk-fill composite. To reduce cuspal deflection of a high compliance cavity, selecting the proper composite based on physical properties is more important than light-curing protocol.
Assuntos
Preparo da Cavidade Dentária , Restauração Dentária Permanente , Resinas Compostas , Materiais Dentários , Humanos , Coroa do DenteRESUMO
OBJECTIVES: The purpose of this study was to develop a new device that can improve the effect of desensitizer using shockwaves and to verify its efficacy. METHODS: A micro-shockwave generator was developed using a piezoelectric actuator (PIA-1000, piezosystem jena GmbH, Jena, Germany), an Arduino Uno microcontroller (Arduino, Torino, Italy), and a high voltage pulser (HVP-1000, piezosystem jena GmbH) at 700â¯V (400 A) and 100⯵s. The occlusal surfaces of 20 extracted human upper and lower third molars without caries or restoration were reduced to expose the occlusal dentin, and the prepared occlusal surfaces were acid-etched with 32% phosphoric acid to remove the smear layer. The tooth specimens were connected to a fluid flow measurement instrument (nanoFlow, IB SYSTEMS, Seoul, Korea), permeability through dentin via dentinal fluid flow (DFF) was measured for 300â¯s, and the average DFF rate (Baseline DFF rate) was calculated. A desensitizer (SuperSeal, Phoenix Dental, Fenton, MI, USA) was applied to the acid-etched occlusal dentin surface of 10 randomly selected tooth specimens, left for 10â¯s, and rubbed with a microbrush for 30â¯s (Group 1). For the remaining teeth, the desensitizer was applied, and a shockwave (100⯵m stroke, 10,000â¯G) was applied for 10â¯s (2 shots/s) and rubbed with a microbrush for 30â¯s (Group 2). After desensitizer application, subsequent DFF was measured for 600â¯s, and the average DFF rate was calculated (post-application DFF rate). DFF was continuously measured in real-time at 25⯱â¯0.5â¯â under a hydrostatic pressure of 25â¯cm. The percentage reduction in DFF rate after desensitizer application (with or without shockwave) was calculated with respect to baseline DFF rate. Data were analyzed with independent t-test (αâ¯=â¯0.05). RESULTS: For all tooth specimens, DFF rate decreased after desensitizer application irrespective of the presence of shockwaves. The percentage reduction in DFF rate of SuperSeal with shockwave (Group 2) was 42.8⯱â¯19.0%, which was significantly higher than the 26.2⯱â¯13.6% of the SuperSeal only group (Group 1) (pâ¯<â¯0.05). SIGNIFICANCE: Measurement of DFF change in real-time shows that shockwaves can help reduce dentin permeability beyond that SuperSeal dentin desensitizer produced alone.
Assuntos
Sensibilidade da Dentina , Camada de Esfregaço , Dentina , Permeabilidade da Dentina , Sensibilidade da Dentina/tratamento farmacológico , Humanos , Microscopia Eletrônica de VarreduraRESUMO
Oral biofilms coat all surfaces in the oral cavity including the exposed dentin surface. This study aimed to investigate biofilm removal by acid etching procedures and the effects of the residual biofilm on dentin surfaces on composite-dentin adhesion. Dentin discs were assigned to five groups: no biofilm formation (C); biofilm formation and no surface treatment (BF); biofilm formation and acid etching (BF-E); biofilm formation and acid etching followed by chlorhexidine soaking (BF-EC); and biofilm formation and rubbing with pumice, followed by acid etching (BF-RE). Biofilms were formed on saliva-precoated dentin discs by soaking the discs in Streptococcus mutans (S. mutans) suspension. Biofilm removal from the dentin surface was evaluated quantitatively and qualitatively by confocal laser scanning microscopy and scanning electron microscopy, respectively. To compare the bond strength of the biofilm-coated dentin discs with the surface treatments, specimens were assigned to four groups: no biofilm formation and acid etching (C-E); BF-E; BF-EC; and BF-RE. Assessments of the micro-shear bond strength and subsequent failure modes were performed. BF-E and BF-EC did not remove the biofilm, whereas BF-RE partially removed the biofilm attached to the dentin (p < 0.05). The bond strength of BF-RE was significantly higher than those of BF-E and BF-EC, but lower than that of C-E (p < 0.05). In conclusion, mechanical biofilm removal is recommended before etching procedures to enhance adhesion to the biofilm-coated dentin.
RESUMO
This paper reports an amphiphilic solution can be used as a new continuous phase to generate double droplet emulsions (water/oil/IPA) with neither surface treatment nor surfactant in PDMS microfluidic chip. The affinity of various amphiphilic solutions in the microchannel was influenced by the polarity ratio and the size of molecules. The polarity ratio of isopropyl alcohol (IPA) was closest to that of the recovered PDMS surface and the chain length of IPA was also suitable for high affinity. IPA showed the highest affinity for the recovered PDMS and was selected as the continuous phase to form oil droplets in a PDMS microchannel. With this new continuous phase solution, IPA, we could successfully generate not only oil droplets but also double emulsions in the PDMS microfluidic chips.
Assuntos
Dimetilpolisiloxanos/química , Emulsões/química , Técnicas Analíticas Microfluídicas/métodos , Óleo Mineral/química , Tensoativos/química , Água/química , 2-Propanol/química , Técnicas Analíticas Microfluídicas/instrumentação , Tamanho da Partícula , Propriedades de SuperfícieRESUMO
OBJECTIVE: The purpose of this study was to investigate the effects of the radiant emittance and cure time of pulse width modulation (PWM)-controlled LED light on the temperature change of composite and dentin. METHODS: Class I cavities (M-D 6mm, B-L 4mm, Depth 2.5mm) were prepared on 30 extracted human molars and vertically sectioned to expose the mesial side of the cavity and tooth. Cavities were filled with Bulk Fill Posterior Restorative (BFP, 3M ESPE) and cured with an LED light. The duty ratio (% of time the light is on) and cure time of the LED light were controlled using an Arduino UNO microcontroller (PWM) as follows (6 groups, n=5): 10%/100 s, 30%/33.3s, 50%/20s, 100%/10s, Increase mode (0â100%)/20s, and Decrease mode (100â0%)/20s. All measurements were performed at 100Hz PWM with the constant total radiant exposure. Thermograms of the specimens were recorded using an infrared thermal camera (VarioCamhr head 700, InfraTec GmbH) for a pre-cure time of 20s, cure time, and a post-cure time of 100s at room temperature of 30±0.5°C. Temperature change data on the composite and dentin surfaces were collected at incremental distances of 0.625mm and 1mm from the top of the cavity to the pulp. Data were statistically analyzed using two-way ANOVA and Tukey's post-hoc test at α=0.05. RESULTS: A rapid temperature increase occurred within the cavity during light curing. The maximum temperature rises (ΔTmax) were observed at 0.625mm apical from the top and middle of the cavity. The ΔTmax ranged from 7.62 to 16.74°C at 0.625mm apical from the top, 4.83 to 11.39°C at the floor of the cavity, and 3.16 to 8.09°C in the dentin 1mm beneath the cavity base. The ΔTmax of composite and dentin increased and the time to reach ΔT=5°C decreased with increasing duty ratio at constant radiant exposure. In the Increase mode, ΔTmax was lower than that of 50%/20s mode. The ΔTmax in the Decrease mode was similar to that of 100%/10s mode. SIGNIFICANCE: The PWM-LED curing light system controlled by a microcontroller provided a useful tool of varying the radiant emittance and cure time with constant radiant exposure to evaluate temperature change of composite and dentin. These result will be helpful to determine proper curing modes with varying radiant emittance of the LED curing light for decreasing temperature change of composite and dentin. At constant radiant exposure and cure times, the Increase mode showed lower and slower temperature rises than the 50%/20s and Decrease mode. Within the limitations of this in vitro study, when radiant exposure is constant, a curing light with lower radiant emittance can induce relatively low thermal transfer, thereby decreasing the risk of pulpal damage.
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Lâmpadas de Polimerização Dentária , Cárie Dentária , Resinas Compostas , Dentina , Humanos , TemperaturaRESUMO
OBJECTIVES: The purpose of this study was to investigate the effects of radiant emittance and cure time of pulse width modulation (PWM)-controlled LED light on polymerization shrinkage/stress kinetics and surface hardness of dental composites. METHODS: A conventional (Filtek Z250) and a bulk-fill (Filtek Bulk Fill Posterior; BFP) composite were investigated. The duty ratio (% of time the light is on) and cure time of the LED light were controlled using an Arduino UNO microcontroller (PWM) as follows: 10%/100s, 20%/50s, 30%/33.3s, 40%/25s, 50%/20s, 100%/10s, Increase mode (0â100%)/20s, and Decrease mode (100â0%)/20s at 50Hz. The radiant exposure of each group was constant. Polymerization shrinkage/stress and Vickers hardness (HV) of composites were measured for each curing condition (n=5). Peak shrinkage/stress rate (Rsh/Rst) and time at peak shrinkage/stress rate (Tsh/Tst) were also determined. RESULTS: There was no significant difference in polymerization shrinkage or HV of composites with varying duty ratio. However, polymerization shrinkage stress, Rsh, and Rst increased and Tsh and Tst decreased with increasing duty ratio. The polymerization shrinkage stress and Rst of the Increase mode group were similar to those of the 50% duty ratio group, and the Tst of the Increase mode was delayed. The polymerization shrinkage/stress kinetics of the Decrease mode group were comparable to those of the 100% duty ratio group. Under the same light curing conditions, polymerization shrinkage/stress, Rsh, Rst, and HV of Z250 were higher than those of BFP, and the Tsh and Tst of Z250 were shorter than those of BFP. SIGNIFICANCE: With constant radiant exposure, evaluation of polymerization shrinkage/stress kinetics and their relationships could be performed by a PWM-controlled LED curing light. These results will be helpful to determine proper curing modes with varying radiant emittance of the LED curing light for decreasing polymerization shrinkage stress of dental composites. Within the limitations of this in vitro study, when radiant exposure is constant, polymerization shrinkage stress with low initial radiant emittance can be reduced compared to that with high initial radiant emittance.
Assuntos
Resinas Compostas/química , Cura Luminosa de Adesivos Dentários/métodos , Lâmpadas de Polimerização Dentária , Materiais Dentários/química , Desenho de Equipamento , Dureza , Teste de Materiais , Polimerização , Propriedades de Superfície , Fatores de TempoRESUMO
OBJECTIVES: We evaluated the outcomes of patients who underwent extracardiac Fontan circulation procedures (ECFP) and received 16-mm polytetrafluoroethylene conduits. METHODS: From June 1997 to May 2015, among the 408 patients who underwent ECFP, 66 patients (Group S) also received 16-mm polytetrafluoroethylene conduits. To compare this patient cohort with similarly sized patients who received larger conduits, a matched cohort (66 patients, Group L) was selected according to age and body weight. RESULTS: The mean age, body weight and Nakata index at ECFP in Groups S and L were 2.9 ± 1.2 and 3.1 ± 1.2 years (P = 0.243), 13.0 ± 2.4 and 13.0 ± 2.3 kg (P = 0.101), 175.3 ± 59.0 and 236.1 ± 75.1 mm2/m2 (P = 0.005), respectively. The mean follow-up periods for Groups S and L were 7.8 ± 6.0 and 9.1 ± 4.9 years (P = 0.150), respectively. The conduit size of Group L was 19.2 ± 1.4 mm (P < 0.001). There was no significant difference in mortality between the groups (P = 0.109). The freedom from reoperation was 94.0 ± 3.4% in Group S and 79.3 ± 5.7% in Group L after 10 years (P = 0.070). Late-occurring morbidities included protein-losing enteropathy (2 in Group S, 4 in Group L; P = 0.491) and thromboembolism (0 in Group S, 4 in Group L; P = 0.206). There was a significant difference in conduit-related events between the groups (1 in Group S, 5 in Group L; P = 0.031). In a paired cohort from the 2 groups including patients who were followed-up for more than 10 years (15 patients from each group), the body mass index was 51.0 ± 33.2% in Group S and 30.3 ± 34.2% in Group L. The decreases in the conduit cross-sectional areas for the paired patients in Group S (n = 20) and Group L (n = 20) were 14.9 ± 19.7% and 24.5 ± 15.5% (P = 0.076), respectively. Coarse liver parenchyma was detected in 9 of 23 (39.1%) patients from Group S and in 7 of 18 (38.8%) patients from Group L upon ultrasonography. CONCLUSIONS: The 16-mm polytetrafluoroethylene conduit for ECFP showed acceptable outcomes and good haemodynamic status in small-sized patients. According to our results, small patients do not require large conduits to accommodate their growth potential.
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Técnica de Fontan/instrumentação , Cardiopatias Congênitas/cirurgia , Politetrafluoretileno , Próteses e Implantes , Tamanho Corporal , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Estimativa de Kaplan-Meier , Modelos Logísticos , Masculino , Análise por Pareamento , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Resultado do TratamentoRESUMO
OBJECTIVE: Extracardiac conduit Fontan procedure has some theoretical advantages over other types of Fontan procedures, such as optimized flow dynamics, a lower frequency of arrhythmias, and technical ease of procedure. However, lack of growth potential and thrombogenicity of the artificial conduit is the main concern and can possibly lead to reoperation for the conduit stenosis. In this study, we investigated the change and the status of the Gore-Tex graft used in extracardiac conduit Fontan procedure. METHODS: Between 1996 and 2005, 154 patients underwent extracardiac conduit Fontan procedure using Gore-Tex graft. Among these, 46 patients underwent cardiac catheterization during follow-up period. We measured the internal diameter of the conduit and inferior vena cava angiographically. RESULTS: Mean follow-up duration was 36.1+/-19.7 months. The conduit diameter used was 16 mm in 10 patients, 18 mm in 16, 20 mm in 14, 22 mm in 4, and 24 mm in 2 patients. The mean conduit-to-inferior vena cava cross-sectional area ratio was 1.25+/-0.33. According to the conduit size used, this ratio was 1.03+/-0.17 for 16 mm conduits, 1.33+/-0.37 for 18 mm, 1.33+/-0.36 for 20 mm, 1.28+/-0.26 for 22 mm, and 1.05+/-0.06 for 24 mm conduits (p<0.05, 16 mm vs 18 mm and 20 mm). The mean percent decrease of the conduit cross-sectional area was 14.3+/-8.5%, and this did not differ significantly according to the conduit size (p=0.82). Follow-up duration and the percent decrease of the conduit cross-sectional area did not show significant correlation (r=0.22, p=0.14). There was no reoperation due to conduit stenosis. CONCLUSIONS: During midterm follow-up of about 3 years, the conduit cross-sectional area decreased by 14%, and this did not differ according to the conduit size used. The extent of decrease of the conduit cross-sectional area remained stable irrespective of the follow-up duration. Sixteen millimeters conduit showed no evidence of clinically significant stenosis, but careful follow-up is warranted because of the possible conduit stenosis relative to the patients' somatic growth.
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Prótese Vascular , Técnica de Fontan/instrumentação , Cardiopatias Congênitas/cirurgia , Politetrafluoretileno , Adolescente , Adulto , Implante de Prótese Vascular/métodos , Criança , Pré-Escolar , Feminino , Técnica de Fontan/métodos , Ventrículos do Coração/anormalidades , Ventrículos do Coração/cirurgia , Humanos , Masculino , Desenho de Prótese , Estudos RetrospectivosRESUMO
OBJECTIVE: The placement of a modified Blalock-Taussig shunt in patients suffering from pulmonary coarctation can result in the aggravation of uneven pulmonary blood flow. This may subsequently obviate the possibility of future performance of the Fontan procedure. The objective of this study was to evaluate mid-term results in patients with pulmonary coarctation who had undergone the placement of a modified Blalock-Taussig shunt, coupled with a pulmonary artery angioplasty. METHODS: We retrospectively reviewed the records of 13 patients who had undergone the placement of a modified Blalock-Taussig shunt, coupled with concomitant pulmonary angioplasty, between September 1998 and August 2002. All patients received follow-up angiographic evaluations. RESULTS: On the ipsilateral side of the modified Blalock-Taussig shunt, we observed a significant increase in the pulmonary artery index during a mean follow-up period of 11+/-5 months (preoperative 82+/-37 mm2/m2, follow-up 129+/-57, p=0.03). On the contralateral side, we also observed a significant increase in the pulmonary artery index (preoperative 90+/-56 mm2/m2, follow-up 137+/-56, p=0.047). There was one late death. During the follow-up period (mean 23+/-18 months), 10 patients received either a bidirectional or total cavopulmonary shunt and five of these patients underwent extracardiac Fontan operations. CONCLUSIONS: Our study demonstrated that the placement of a modified Blalock-Taussig shunt, with concomitant pulmonary artery angioplasty, constitutes a good initial surgical strategy in cases of univentricular heart with pulmonary coarctation.
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Arteriopatias Oclusivas/cirurgia , Cardiopatias Congênitas/cirurgia , Artéria Pulmonar/cirurgia , Anastomose Cirúrgica/instrumentação , Angioplastia/métodos , Arteriopatias Oclusivas/fisiopatologia , Procedimentos Cirúrgicos Cardíacos/instrumentação , Desenho de Equipamento , Cardiopatias Congênitas/patologia , Cardiopatias Congênitas/fisiopatologia , Ventrículos do Coração/anormalidades , Humanos , Lactente , Recém-Nascido , Politetrafluoretileno , Artéria Pulmonar/patologia , Artéria Pulmonar/fisiopatologia , Circulação Pulmonar/fisiologia , Reoperação , Estudos Retrospectivos , Resultado do TratamentoRESUMO
BACKGROUND: Durability of bioprosthetic valves in the pulmonary position is suboptimal. The objective of this study was to evaluate midterm outcomes of hand-sewn polytetrafluoroethylene (PTFE) bicuspid pulmonary valve replacement. METHODS: A retrospective review of 119 patients who underwent bicuspid pulmonary valve replacement using 0.1-mm PTFE membrane between June 2009 and May 2014 was performed. Reintervention was defined as any surgical or percutaneous catheter procedure on the PTFE pulmonary valve. Structural valve deterioration (SVD) was defined as development of a peak pressure gradient equal to or greater than 50 mm Hg or at least a moderate amount of pulmonary regurgitation on follow-up echocardiography. RESULTS: The median age at pulmonary valve replacement was 16.9 years (range 5 months to 57.1 years). Fundamental diagnoses were tetralogy of Fallot (n = 71), pulmonary atresia with ventricular septal defect (n = 21), double-outlet right ventricle (n = 13), and others (n = 14). The median valve size was 26 mm (range 12 to 30 mm). Two hospital deaths (1.7%) occurred, from ventricular dysfunction and infective endocarditis. At discharge, no patient showed significant pulmonary regurgitation or stenosis. Follow-up completeness was 94.0%, and the median duration of follow-up was 2.6 years (range 0.1 to 5.2 years). One late death occurred, the result of infective endocarditis involving the PTFE pulmonary valve. Actuarial survival was 97.1% ± 1.6% at 5 years. One patient underwent excision of the PTFE pulmonary valve because of infective endocarditis. Freedom from pulmonary valve reoperation was 99.1% ± 0.9% at 5 years. Ten patients developed SVD during follow-up, and 6 of them underwent an interventional catheter procedure. Freedom from pulmonary valve reintervention and SVD at 5 years was 90.7% ± 3.4% and 86.5% ± 4.0%, respectively. CONCLUSIONS: Midterm outcomes of hand-sewn PTFE bicuspid pulmonary valve replacement were acceptable. Long-term follow-up of this cohort is mandatory to determine the durability of this valve.
Assuntos
Cardiopatias Congênitas/cirurgia , Implante de Prótese de Valva Cardíaca/métodos , Valva Mitral/anormalidades , Politetrafluoretileno , Valva Pulmonar/cirurgia , Adolescente , Adulto , Criança , Pré-Escolar , Ecocardiografia , Feminino , Seguimentos , Cardiopatias Congênitas/diagnóstico , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Valva Mitral/cirurgia , Valva Pulmonar/anormalidades , Valva Pulmonar/diagnóstico por imagem , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Adulto JovemRESUMO
OBJECTIVES: The durability of bioprosthetic valves in the pulmonary position is suboptimal. The objectives of this study were to evaluate the early results of polytetrafluoroethylene (PTFE) bicuspid pulmonary valve (PV) implantation and to better define the function of this valve by magnetic resonance imaging (MRI). METHODS: Fifty-six patients who underwent PTFE bicuspid PV implantation between June 2009 and August 2011 were retrospectively analysed. The median age was 17.5 years and median valve size was 26 mm. Fundamental diagnoses were tetralogy of Fallot (n = 38), pulmonary atresia with ventricular septal defect (n = 8), double outlet right ventricle (n = 7) and absent PV syndrome (n = 3). Thirty-two patients with pulmonary regurgitation (PR) underwent MRI preoperatively and 22 of them underwent follow-up MRI at a median of 6.7 months postoperatively. RESULTS: There was one early death. Postoperative echocardiography (n = 53) showed no or trivial PR in 49 patients and mild PR in 4. Median follow-up duration was 15.2 months. There was no late death or reoperation. Follow-up echocardiography (n = 41) performed at a median of 7.5 months postoperatively showed no or trivial PR in 33 patients and mild PR in 8 patients. Follow-up MRI showed a significant reduction in right ventricular volumes and improvement in biventricular function. The median PR fraction of this valve was 10%. CONCLUSIONS: Early results of bicuspid PV implantation using PTFE membrane were satisfactory. PTFE bicuspid PV demonstrated excellent performance for the short term as evidenced by echocardiography and MRI. Long-term follow-up is mandatory to determine the durability of this valve.
Assuntos
Próteses Valvulares Cardíacas , Imageamento por Ressonância Magnética/métodos , Politetrafluoretileno , Implantação de Prótese/instrumentação , Implantação de Prótese/métodos , Valva Pulmonar/cirurgia , Adolescente , Adulto , Criança , Pré-Escolar , Bases de Dados Factuais , Feminino , Humanos , Masculino , Membranas Artificiais , Valva Pulmonar/patologia , Valva Pulmonar/fisiologia , Estudos Retrospectivos , Tetralogia de FallotRESUMO
Here, we report our experience with pulmonary valve (PV) repair using neoleaflet implantation in children and adolescents. Between April 2005 and May 2009, 20 patients underwent late PV repair with neoleaflet implantation for pulmonary regurgitation (PR) after reconstruction of the right ventricular outflow tract at <18 years of age. In patients with sufficient remaining native PV leaflets, the neoleaflet was implanted with a polytetrafluoroethylene membrane or fresh autologous pericardium to coapt with the remaining native PV leaflets. The median age at operation was 13 years (2-18 years). The median follow-up duration was 12 months (2-51 months). There was no early or late death. During follow-up, no significant PR was observed, but significant pulmonary stenosis (PS) developed in two patients who had a combined PS. The indexed right ventricular end diastolic dimension decreased during follow-up. At the latest follow-up, all patients were in New York Heart Association functional class I or II. PV repair with neoleaflet implantation can be performed safely and the outcome is satisfactory in the short-term, but attention must be paid in cases with combined PS. Longer follow-up should be carried out to investigate the changes in leaflet mobility and function, and pulmonary annular growth.