RESUMO
Responsive polymers undergo reversible or irreversible physical or chemical modifications in response to a change in environment or stimulus, e.g., temperature, pH, light, and magnetic or electric fields. Polymeric nanoparticles (NPs), which constitute a diverse set of morphologies, including micelles, vesicles, and core-shell geometries, have been successfully prepared from responsive polymers and have shown great promise in applications ranging from drug delivery to catalysis. In this review, we summarize pH, thermo-, photo-, and enzymatic responsiveness for a selection of polymers. We then discuss the formation of NPs made from responsive polymers. Finally, we highlight how NPs and other nanomaterials are enabling a wide range of smart applications with improved efficiency, as well as improved sustainability and recyclability of polymeric systems.
Assuntos
Nanopartículas/química , Polímeros/química , Técnicas Biossensoriais/instrumentação , Técnicas Biossensoriais/métodos , Catálise , Portadores de Fármacos/química , Enzimas/metabolismo , Concentração de Íons de Hidrogênio , Luz , Micelas , TemperaturaRESUMO
We studied the directed assembly of soft nanoparticles through rapid micromixing of polymers in solution with a nonsolvent. Both experiments and computer simulations were performed to elucidate the underlying physics and to investigate the role of various process parameters. In particular, we discovered that no external stabilizing agents or charged end groups are required to keep the colloids separated from each other when water is used as the nonsolvent. Furthermore, the size of the nanoparticles can be reliably tuned through the mixing rate and the ratio between polymer solution and nonsolvent. Our results demonstrate that this mechanism is highly promising for the mass fabrication of uniformly sized colloidal particles, using a wide variety of polymeric feed materials.