RESUMO
To prepare one electroactive and biodegradable biomaterial for biomedical application, a new synthetic strategy was developed to synthesize a novel electrically conductive biodegradable polyphosphazene polymer containing parent aniline pentamer (PAP) and glycine ethyl ester (GEE) as side chains by a nucleophilic substitution reaction. The electrical conductivity of the polymer is approximately 2 x 10(-5) S cm(-1) in the semiconducting region upon preliminarily protonic-doped experiment. The degradation and RSC96 Schwann cells experiments in vitro prove that the polymer is biodegradable and beneficial to the cell adhesion and proliferation. The as-synthesized polymer also shows good solubility in common organic solvent and good film-forming properties. This new type of polymer has potential applications as scaffolds for neuronal and cardiovascular tissue engineering or other biomedical devices that require electroactivity.
Assuntos
Implantes Absorvíveis , Materiais Biocompatíveis/química , Compostos Organofosforados/química , Polímeros/química , Células de Schwann/citologia , Células de Schwann/fisiologia , Engenharia Tecidual/métodos , Adesão Celular , Técnicas de Cultura de Células/métodos , Proliferação de Células , Células Cultivadas , Condutividade ElétricaRESUMO
The static friction behavior between a porous bioceramic material and an intestinal mucus film was investigated in order to develop a new intestine robotic endoscope. Here, the friction couple is porous beta-tricalcium phosphate (beta-TCP) and an artificial intestine mucus film. The effect of pore size of the beta-TCP material on the friction behavior is investigated. The results illustrated that in this friction system there is a relatively small normal force upon the intestinal mucus film of the intestine wall during locomotion. The maximum static friction force in this friction couple varies with the pore size of the porous beta-TCP material.
Assuntos
Materiais Biocompatíveis/química , Materiais Biomiméticos/química , Fosfatos de Cálcio/química , Cerâmica/química , Mucosa Intestinal/fisiologia , Modelos Biológicos , Animais , Simulação por Computador , Fricção , Humanos , Teste de Materiais , Membranas/fisiologia , Porosidade , Estresse MecânicoRESUMO
OBJECTIVE: To investigate the applicability of PDLLA/nano-HA compound plates used in internal fixation of mandibular fractures. METHODS: Rabbit mandibular fracture model was used in this study. Clinical observation, the amount of callus, histological observation were studied and compared with PDLLA plates. RESULTS: All fractures were fixed rigidly. There was 1 animal experienced local inflammation and then forming fistula in the side of PDLLA plate at postoperative 2 and 3 weeks. No side-effects were found in the side of compound plates. During the early stage of bone healing, the quality of callus in the side of compound plates was apparently more than that in the other side, and histological study showed that the osteoblasts and fibroblasts were more active in the side of compound plate in the early healing stage. CONCLUSIONS: PDLLA/nano-HA compound plate has a proper degradation time. Compared with PDLLA plates, it is more effective and safer when used in mandibular fracture.