Is THP-1 viability affected by the crystallinity of nanostructured carbonated hydroxyapatites?

In daily clinical practice, there is a notable variety of synthetic bone substitute, with various resorption rates, different chemical and structural characteristics that influence on bone regeneration and are not suitable for every clinical use. New biomaterials based on nanotechnology have been developed to be bioabsorbable as new bone is formed. This study intends to evaluate THP-1 cell viability when exposed to extracts of unsintered nanostructured carbonated hydroxyapatite (cHA) microspheres processed at 5 and 37°C compared to sintered hydroxyapatite processed at 90°C. cHA shows, in previous studies, biocompatibility, and better bioabsorption rates, consequently, improve the deposition of new bone and tissue repair. The results demonstrated that the tested biomaterials did not activate inflammatory role through THP-1 cells and did not affect activated macrophages independently of their crystallinities, suggesting their safety and biocompatibility. These results are of fundamental importance for the advancement of research on smart materials, especially in what controls the effect of nanostructured cHA microspheres in the biological environment, seems to be a promising biomaterial in clinical application on regenerative medicine.

MORDIDA CRUZADA ANTERIOR: POSSIBILIDADES DE TRATAMENTO NA DENTIÇÃO DECÍDUA E MISTA / ANTERIOR CROSSBITE: TREATMENT POSSIBILITIES IN DECIDUOUS AND MIXED DENTITION

A mordida cruzada anterior (MCA) refere-se a uma maloclusão cuja relação vestíbulo-lingual entre incisivos superiores e inferiores é anormal, com sobressaliência negativa. Esta alteração pode promover comprometimento da estética dento-facial e das funções do sistema estomatognático. A MCA pode ser classificada em 3 tipos: Dentária (MCAD), Funcional (MCAF) e esquelética (MCAE). O objetivo deste trabalho foi, por meio de uma revisão de literatura, apresentar as diferentes possibilidades de tratamento da MCA nas dentições decídua e mista. O tratamento da MCAD tem como objetivo a correção das inclinações anormais dos elementos envolvidos. O tratamento da MCAF pode ser realizado por movimentação dentária pelas pistas diretas preconizadas por Planas. A abordagem da MCAE tem como objetivo a correção esquelética e dependerá do grau de displasia óssea e da idade de início do tratamento. Concluiu- se que a MCA deve ser tratada tão logo seja diagnosticada, por meio das diferentes formas de tratamento apresentadas, de acordo com a etiologia e apresentação clínica. Todos os tratamentos propostos apresentam altos índices de sucesso se corretamente planejados e executados.

Anterior crossbite (MCA) refers to a malocclusion whose vestibular- lingual relationship between upper and lower incisors is abnormal, with a negative overjet. This alteration may promote impairment of dento-facial aesthetics and functions of the stomatognathic system. The MCA can be classified into 3 types: Dental (MCAD), Functional (MCAF) and skeletal (MCAE). The objective of this literature review was to present the different possibilities of MCA treatment in the deciduous and mixed dentitions. The treatment of MCAD aims at correcting the abnormal inclinations of the involved elements. The treatment of MCAF can be performed with composite as an inclined plane tracks recommended by Planas. The MCAE approach aims at skeletal correction and depends on the degree of bone dysplasia and the age at which treatment begins. According this study, we can conclude that the MCA should be treated as soon as diagnosed, by the different forms of treatment presented, according to etiology and clinical presentation. All the proposed treatments may have high success rates if correctly planned and executed.