RESUMO
Compared with traditional internal fixation devices, bone adhesives are expected to exhibit remarkable advantages, such as improved fixation of comminuted fractures and maintained spatial location of fractured scattered bone pieces in treating bone injuries. In this review, different bone adhesives are summarized from the aspects of bone tissue engineering, and the applications of bone adhesives are emphasized. The concepts of "liquid scaffold" and "liquid plate" are proposed to summarize two different research directions of bone adhesives. Furthermore, significant advances of bone adhesives in recent years in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity are discussed. We conclude this topic by providing perspectives on the state-of-the-art research progress and future development trends of bone adhesives. We hope this review will provide a comprehensive summary of bone adhesives and inspire more extensive and in-depth research on this subject.
Assuntos
Consolidação da Fratura/efeitos dos fármacos , Fraturas Ósseas/tratamento farmacológico , Substâncias Macromoleculares/farmacologia , Adesivos Teciduais/farmacologia , Animais , Regeneração Óssea/efeitos dos fármacos , Osso e Ossos/efeitos dos fármacos , Linhagem Celular Tumoral , Humanos , Substâncias Macromoleculares/química , Osseointegração/efeitos dos fármacos , Adesivos Teciduais/química , Engenharia Tecidual , Alicerces Teciduais/químicaRESUMO
The present study was designed to investigate the in vivo drug release and antibacterial properties of a novel mesoporous hydroxyapatite/chitosan (mesoHA-CS) composite loaded with vancomycin (VCM). VCM-mesoHA/CS composite was prepared via a freeze-drying method. The successful loading of VCM in the composite scaffold was verified by FT IR analyses. SEM observation revealed the mesoporous structure of the VCM-mesoHA/CS composite with the pore size of 50-100 µm. Medicated composites were then implanted into the muscular pockets of extremity in rabbits. The results demonstrated that local VCM concentration in muscle tissue could maintain higher than the minimum inhibitory concentration at the site of implantation for long time (i.e. 4 weeks). As a result, the number of viable methicillin-resistant Staphylococcus aureus (MRSA) on mesoHA/CS could be significantly suppressed after the VCM-mesoHA/CS implantation. These results indicated that the mesoHA/CS composite may be promising scaffold as drug storage and release vehicle applied for local antibacterial drug release and bone repair.