UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent.

The Food and Drug Administration recently cleared silver diamine fluoride for reducing tooth sensitivity. Clinical trials document arrest and prevention of dental caries by silver diamine fluoride. This off-label use is now permissible and appropriate under U.S. law. A CDT code was approved for caries arresting medicaments for 2016 to facilitate documentation and billing. We present a systematic review, clinical indications, clinical protocol and consent procedure to guide application for caries arrest treatment.

Topical iodine and fluoride varnish combined is more effective than fluoride varnish alone for protecting erupting first permanent molars: a retrospective cohort study.

OBJECTIVE: This communication examines the combined effect of topical polyvinylpyrollidone (PVP)-iodine plus fluoride varnish in the prevention of tooth decay in erupting first permanent molars in an ongoing public health program. METHODS: The evaluation employed a retrospective cohort design with two groups of children 60-83 months. Cohort 1 (2004-05) received three times per school year topical fluoride varnish, and Cohort 2 (2008-09) received topical application of 10 percent PVP-iodine followed at each visit with topical fluoride varnish. The children were examined clinically at the beginning and end of the school year. RESULTS: The proportion of children with caries-free first permanent molars in Cohort 2 (PVP-iodine plus fluoride varnish) was 0.883 and was greater than that in Cohort 1 (varnish), which was 0.785 (Chi-square = 1.000E1, df 1, P < 0.002). CONCLUSIONS: This evaluation of an ongoing dental public health program adds evidence that topical antiseptics applied at the same time as fluoride varnish are more effective than varnish alone. Randomized trials are needed.

Expanded studies of the pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.

Previous work described the pharmacokinetics and clinical effects of multidose sublingual triazolam (Halcion; Pharmacia & Upjohn Co, Kalamazoo, Mich). This laboratory study evaluated the hypothesis that incremental dosing of triazolam produces dose-dependent central nervous system depression that is profound and long lasting. Forty-nine healthy adults between the ages of 21 and 39 years, not receiving dental treatment, were randomly assigned to placebo (n = 12) or 1 of 3 triazolam groups (0.25-mg single dose, n = 12; 0.5 mg divided between 2 equal doses for 60 minutes, n = 12; or 0.75 mg divided among 3 doses for 90 minutes, n = 13). Plasma triazolam concentrations were determined. Bispectral index (BIS) and the Observer Assessment of Alertness/Sedation scale were used to assess sedation. Plasma triazolam concentrations increased with time in all subjects, with Tmax and Cmax both increasing dose dependently. Compared with placebo, all dosing paradigms produced dose-dependent BIS suppression and sedation. The single dose of 0.25 mg reached its peak BIS suppression at 90 (81 +/- 7) minutes and sedation at 120 (3.6 +/- 0.5) minutes and returned to baseline before 360 minutes. In contrast, incremental dosing of 0.5 and 0.75 mg produced profound and long-lasting BIS suppression and sedation that did not plateau until either 180 or 210 minutes as measured by the BIS index (67 +/- 14 and 60 +/- 16 at 0.5 and 0.75 mg, respectively) and 150 minutes as measured by the Observer Assessment of Alertness/Sedation scale (3.2 +/- 1.0 and 2.7 +/- 0.4 at 0.5 and 0.75 mg, respectively). These data more fully characterize the effects of incremental dosing with sublingual triazolam and provide additional insight for discharge safety recommendations.

Fluorides and Other Preventive Strategies for Tooth Decay.

We focus on scalable public health interventions that prevent and delay the development of caries and enhance resistance to dental caries lesions. These interventions should occur throughout the life cycle, and need to be age appropriate. Mitigating disease transmission and enhancing resistance are achieved through use of various fluorides, sugar substitutes, mechanical barriers such as pit-and-fissure sealants, and antimicrobials. A key aspect is counseling and other behavioral interventions that are designed to promote use of disease transmission-inhibiting and tooth resistance-enhancing agents. Advocacy for public water fluoridation and sugar taxes is an appropriate dental public health activity.

The Effect of New Oral Care Technologies on the Need for Dentists in 2040.

This article addresses changes in technology of oral self-care or professional care that may increase or decrease the demand for dentists by 2040. The focus is on dental caries, periodontitis, and temporomandibular joint disorders (TMD), as the first two are the main areas of current practice and because TMD is an area for growth. To address this question, the authors examined the scientific literature and government registries to identify recent or soon-to-be-available technologies. They also examined the state of translational efficiency, dissemination, and adoption of advances into dental practice. The pipeline of applicable technology is limited. Nevertheless, between now and 2040, emerging technologies will continue to reduce the need for training more dentists, while no technologies are emerging that will significantly increase the need. Technology in dentistry is adopted slowly as is true in other medical specialties. If a breakthrough product did appear, the results of industry-sponsored trials would be viewed skeptically by the profession, and considerable time would be required to establish the applicability of the findings to the broader population. Greater integration of dentistry into preventive medicine, with dentists offering point-of-service medical testing for systemic disease as suggested by the American Dental Association (ADA), would require a paradigm shift, can occur only over a lengthy period, and is unlikely to impact this assessment. This article was written as part of the project "Advancing Dental Education in the 21st Century."

Costs and Resource Use Among Child Patients Receiving Silver Nitrate/Fluoride Varnish Caries Arrest.

PURPOSE: The purpose of this study was to assess the impact of silver nitrate/fluoride varnish (SN/FV) on care costs. METHODS: A retrospective matched cohort study, using Oregon Medicaid claims (January 1, 2012 to December 31, 2014) for patients younger than 21 years old, compared patients treated with SN/FV to matched patients not treated with SN/FV. The number of services and costs were compared using student's t test and generalized estimating equation (GEE) regression models. RESULTS: Patients treated with SN/FV (n equals 4,612) and matched patients treated conventionally (n equals 13,498) averaged 28±7 (SD) months of continuous eligibility based on initial treatment date. The number of first-year services and total services over an average of 28 months were higher for patients treated with SN/FV (10.6 versus 6.7 in year one; 19.3 versus 8.8 overall; P<0.0001). Excluding diagnostic/preventive services, costs were higher in patients treated conventionally than patients treated with SN/FV in the first year. Overall costs were similar ($698 versus $707; P=.52). The average number of services was 58 percent higher (95 percent confidence interval [CI] 1.54 to 1.63) for patients treated with SN/FV, but costs remained similar. CONCLUSION: Patients treated with silver nitrate/fluoride varnish accrued a greater number of services and higher total costs over approximately 28 months but lower treatment costs than patients treated conventionally.

Topical iodine and fluoride varnish effectiveness in the primary dentition: a quasi-experimental study.

PURPOSE: Combining fluorides with antimicrobials may be of value because fluorides alone do not provide complete protection. The purpose of this quasi-experimental study was to compare the effectiveness of combined topical treatment with 10% polyvinyl-pyrollidone iodine (PVP-I) and 5% sodium fluoride varnish (FV) with FV alone. METHODS: One hundred seventy-two 12- to 30-month-old children received either combined or single therapy in Majuro, Republic of the Marshall Islands, between June 2008 and March 2009. The children received a mean of 2.5 treatments in the PVP-I combined group (range=2-3) and 2.8 treatments in the FV group (range=2-4) and were then examined. RESULTS: The percentage of children with any new decayed primary teeth was 41% (n=81) in the PVP-I combined group and 54% (n=90) in the FV group. Multivariate log-binomial regression was used to compare the rate of any new decay between groups, controlling for the number of teeth at baseline and the number of treatment visits. The risk ratio for treatment is 0.69 (95% confidence interval [CI]=0.51-0.94). No adverse effects were observed. CONCLUSION: Combined treatment with 10% polyvinylpyrollidone iodine and 5% sodium fluoride varnish reduced the rate of new tooth decay by 31% over fluoride varnish alone.

Dental manpower development in the Pacific: case study in the Republic of the Marshall Islands.

This case study reports the ongoing progress and results of a manpower development program to expand indigenous dental personnel at four levels in the Republic of the Marshall Islands. The program was designed to: 1) increase the number of Marshallese students who successfully complete dentistry training; 2) recruit and train a group of Marshallese high school graduates in dental assisting for service in new preventive outreach programs within the community; 3) enhance the dental training of health assistants providing primary medical care to outer islands away from the main population centers of Majuro and Ebeye; and 4) provide in-service training on tooth decay prevention for Head Start teachers. The program resulted in the training of one Marshallese dentist and two Marshallese dental therapist, 16 primary care health aides who received oral health training for work in the outer island dispensaries, and 200 Head Start and kindergarten teachers who completed in-service training in oral health. Additional expertise was shared with other United States Affiliated Pacific Islands (USAPI) to enhance the dental workforce throughout the Pacific.