Study of Biointegration and Elastic-Strength Properties of a New Xenopericardium-Based Biomaterial for Reconstructive Cardiovascular Surgery.

We analyzed biocompatibility, elastic-strength properties, and biointegration potential of a new biomaterial made of xenopericardium for reconstructive cardiovascular surgery. The biomaterial manufactured by the proposed technology demonstrated high biocompatibility and biointegration potential and its elastic-strength properties 2-4-fold surpassed that of native pericardium. The obtained results attested to good prospects of using the proposed technology for preparing biomaterials for reconstructive cardiovascular surgery.

[Clinical appliance of new biologic glue "Biokley-LAB" in cardiac surgery with artificial circulation]. / Klinicheskoe primenenie novogo biologicheskogo kleia "Bioklei-LAB" pri operatsiiakh na serdtse v usloviiakh iskustvennogo krovoobrashcheniia.

Data on clinical appliance of domestically produced two-component gelatin-resorcin glue "Biokley-LAB" in difficult surgeries on the ascending aorta and aortal valve with artificial circulation demonstrate that this glue is good prophylactic haemostatic remedy which reduces risk of postoperative bleedings.

Improving biocompatibility of heart valve and vascular transplants by their devitalization and repopulation by recipient cells.

Inoculation of cells derived from the aorta of Wistar rats on devitalized porcine aortic walls 2-4-fold reduced their calcinosis after subcutaneous implantation to Wistar rats. Inoculation of Wistar rat bone marrow mesenchymal cells selected by adhesion activity did not reduce tissue calcinosis. The results indicate good prospects of repopulation of devitalized heart valve and vessel transplants by recipient vascular cells for reducing transplant calcinosis and improvement of their biocompatibility.