Risk factors in burning mouth syndrome: a case-control study based on patient records.

Burning mouth syndrome (BMS) is a multifactorial condition which is still poorly understood. The aim of this study was to evaluate a group of patients with BMS, as compared to a control group, and to describe related local and systemic factors. Records of patients referred to the Oral Pathology Service at the School of Dentistry over a period of 7 years were considered for the study, within which 32 patients with a diagnosis of BMS were found. A randomized group matched for age and gender was also evaluated for the study. Data were analyzed statistically using the SPSS 12.0 for Windows. Prevalence of BMS was 0.99% (32 BMS patients/3,243 records), considering that females were more commonly affected than were males and that the majority of the individuals were in their sixties. The univariate analysis performed comparing the two groups revealed statistical differences concerning the presence of gastrointestinal diseases (p = 0.003) and urogenital diseases (p = 0.012). The intake of H-2 receptor antagonist and proton pump inhibitor drugs (p = 0.015) also proved to be significant. Logistic regression analysis confirmed that gastrointestinal and urogenital problems were indeed risk factors that were solely associated with BMS. Although a diversity of related factors could be identified, gastrointestinal problems were the most prevalent, suggesting that the management of BMS patients requires attention and an appropriate approach to such disorders.

Carcinoma de células escamosas de boca: relação entre graduação histopatológica e características clínicas da neoplasia / Oral squamous cell carcinoma: relation between histopathologic graduation and clinical features of the neoplasia

As características histopatológicas do carcinoma de células escamosas de boca (CCEB) têm sido utilizadas para previsão do comportamento clínico desta neoplasia. Objetivo: Descrever as características de uma amostra de CCEB e verificar a relação da graduação histopatológica com características do indivíduo e da lesão, procurando identificar associações relacionadas com o comportamento agressivo desta neoplasia. Métodos: O protocolo foi aprovado pelo Comitê de Ética em Pesquisa da UFMG. Todos os casos selecionados foram de CCEB diagnosticados no serviço de Patologia Bucal da Faculdade de Odontologia da UFMG e no serviço de Estomatologia do Hospital Municipal Odilon Behrens. A amostra compreendeu 72 casos de CCEB, sendo 56 homens e 16 mulheres. Os indivíduos foram submetidos a questionários quanto aos seus hábitos tabagista e etilista, tempo de evolução da lesão e sintomatologia. Foram realizados exames clínicos, e os fragmentos tumorais foram revisados e graduados através do método proposto por Bryne et al. (1989). Os dados foram analisados, pelo teste do Qui-quadrado, no software SPSS 12.0 (p menor que 0,05). Resultados: Os tumores foram graduados como 23 bem diferenciados (32%), 23 moderadamente diferenciados (32%) e 26 mal diferenciados (36%). Neoplasias histologicamente mais agressivas foram mais frequentemente localizadas em língua ou assoalho bucal, sem, entretanto diferença estatisticamente significante (p maior que 0,05). A maioria das lesões mal diferenciadas (15 / 71,4%) exibiu metástase regional e o envolvimento linfonodal mostrou associação com tamanho da lesão (p menor que 0,05). Conclusão: Os resultados sugerem que algumas características da neoplasia, tais como, tamanho do tumor, sua localização (língua e/ou assoalho bucal), bem como a ocorrência de metástases para linfonodos locais, podem estar relacionados com a agressividade histológica do CCEB.

The histopathological characteristics of oral squamous cell carcinoma (OSCC) have been used to predict the clinical behavior of this neoplasia. Purpose: The aim of this study was describe the characteristics of an OSCC sample and verify the relation between histological grading and characteristics of the subjects and the tumor, identifying associations with the aggressive behavior of this lesion. Method: The protocol of this study was approved by the Research Ethics Committee from Universidade Federal de Minas Gerais (COEP-UFMG). OSCC cases selected were diagnosed in Oral Diagnosis Service at the Dentistry School of UFMG and in Odilon Behrens Hospital. ). The sample consisted of 72 patients with OSCC, been 56 men and 16 women. The patients were submitted to a questionnaire about tobacco and alcohol habits, evolution time and symptomatology. Clinical examinations were performed and tumor fragments were reviewed and graded in accordance to the criteria proposed by Bryne et al. (1989). The data were analyzed in SPSS (Statistic Package for Social Sciences) 12.0 for Windows (p less than 0,05). Results: Twenty-three tumors were graded histologically as well differentiated (32%), 23 moderately differentiated (32%) and 26 poorly differentiated (36%). Neoplasms histologically more aggressive were often located in tongue and floor of mouth, however, without statistical significance (p greater than 0,05). The majority of the well differentiated lesions (71,4%) exhibited regional metastasis and the lymph node involvement showed association with tumor's size (p less than 0,05). Conclusion: The results suggest that histological aggressiveness could be associated with size and regional dissemination in OSCC and that tumors located in tongue and floor of mouth may exhibit more aggressive behavior.