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1.
Jpn J Antibiot ; 43(12): 2035-68, 1990 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-2086820

RESUMO

To evaluate objectively clinical efficacy, safety and usefulness of cefuroxime axetil (CXM-AX) in acute dental infections (periodontitis, pericoronitis and gnathitis), we carried out a comparison study using cefaclor (CCL) as the control. Both drugs were orally given after meals in a dose level of 250 mg (potency) t.i.d. for 3-7 days. 1. Clinical efficacy rates in all the treated cases were 81.6% (102/125) in the CXM-AX group and 82.5% (104/126) in the CCL group according to the assessment by physicians in charge, and 89.6% (112/125) and 83.3% (105/126), respectively, according to the assessment based on scores. No significant difference was found between the 2 treatment groups. In clinical efficacy (assessment by score) classified by background factors, efficacy rate in the CXM-AX group (90.6%, 58/64) was significantly higher (P less than 0.05) than that in the CCL group (75.0%, 48/64) in cases receiving no surgical treatment on the first day of drug administration. Other background factors than the above (no surgical treatment) factor or scores on the first day of drug administration, however, did not appear to influence clinical efficacies of 2 treatment groups. 2. As for the bacteriological response in all the treated cases, elimination rate in the CXM-AX group was 73.7% (28/38) and that in the CCL group, 78.3% (36/46), without significant difference between the 2 groups. 3. Regarding the safety, no significant difference was found between the 2 treatment groups. Adverse reactions were observed in 1 out of 128 cases (0.8%) in the CXM-AX group and 6 out of 132 cases (4.5%) in the CCL group. Abnormal laboratory test values were noted in 8 out of 86 cases (9.3%) in the CXM-AX group and 5 out of 91 cases (5.5%) in the CCL group. None of these differences between 2 treatment groups was statistically significant. 4. Usefulness rates in all the treated cases were 81.6% (102/125) in the CXM-AX group and 81.7% (103/126) in the CCL group, thus significant difference was observed between the 2 groups. From the above results, CXM-AX is considered to be a useful drug like CCL in the treatment of acute dental infections.


Assuntos
Infecções Bacterianas , Cefuroxima/análogos & derivados , Doenças Maxilomandibulares/tratamento farmacológico , Pericoronite/tratamento farmacológico , Periodontite/tratamento farmacológico , Pró-Fármacos/uso terapêutico , Doença Aguda , Adolescente , Adulto , Idoso , Bactérias/efeitos dos fármacos , Bactérias/isolamento & purificação , Cefaclor/efeitos adversos , Cefaclor/farmacologia , Cefaclor/uso terapêutico , Cefuroxima/efeitos adversos , Cefuroxima/farmacologia , Cefuroxima/uso terapêutico , Método Duplo-Cego , Resistência Microbiana a Medicamentos , Feminino , Humanos , Doenças Maxilomandibulares/microbiologia , Masculino , Pessoa de Meia-Idade , Pericoronite/microbiologia , Periodontite/microbiologia , Pró-Fármacos/efeitos adversos , Pró-Fármacos/farmacologia
2.
Bull Tokyo Dent Coll ; 37(4): 183-7, 1996 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9151574

RESUMO

Based upon the observation that most oral bacteria are negatively charged, we attempted to restrain the development of oral bacteria in saliva by applying a constant electric potential to an electrode. The development of salivary bacteria was clearly restrained by applying 0.74V electric current for 30 min. This restraint was in inverse proportion to the concentration of the suspension of salivary bacteria. The authors hypothesize that the electrochemical restraining was based on electron transfer between the salivary bacteria and the electrode.


Assuntos
Antissepsia/instrumentação , Bactérias/química , Controle de Infecções Dentárias/instrumentação , Saliva/microbiologia , Adulto , Contagem de Colônia Microbiana , Eletroquímica , Eletrodos , Elétrons , Estudos de Avaliação como Assunto , Feminino , Humanos , Troca Iônica , Masculino , Pessoa de Meia-Idade , Saliva/química
3.
Ou Daigaku Shigakushi ; 16(1): 24-30, 1989 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-2640791

RESUMO

The results of peripheral nerve repair have been greatly improved in the last few years following the introduction of micro-surgery and increased application of free autologous nerve transplants. In the field of oral surgery, a rich experience has been made in plastic and reconstructive repair. The inferior alveolar nerve is endangered by a series of mandibular fractures, with fracture lines running along the nerve canal. For plastic repair of the inferior alveolar nerve, we interpose an autologous transplant from the greater auricular nerve.


Assuntos
Fraturas Mandibulares/complicações , Tecido Nervoso/transplante , Traumatismos do Nervo Trigêmeo , Adulto , Humanos , Masculino , Nervo Mandibular/cirurgia , Processo Mastoide/inervação , Regeneração Nervosa
4.
Ou Daigaku Shigakushi ; 16(3): 124-9, 1989 Nov.
Artigo em Japonês | MEDLINE | ID: mdl-2640798

RESUMO

We have experienced epithelial dysplasia and invasive carcinoma of oral cavity, showing punctation and mosaic like atypical vessels confirmed by usual photographing. Case 1: 42-year-old man. After resection of tongue leukoplakia, the punctation appeared in the distal region of resected wound. Pathological findings were epithelial dysplasia, and expansion of capillaries in the stromal papillae were close to the surface. Case 2: 55-year-old woman. Punctation and mosaic like atypical vessels were recognized in the buccal mucosa, extending from the gingival carcinoma. Pathological findings were epithelial dysplasia and carcinoma in situ in punctation, and early invasive carcinoma in mosaic. There were irregularly expanded capillaries in the stromal papillae being close to the surface at both mosaic and punctation area. Although punctation, atypical vessels and mosaic are the colposcopic findings of uterine cervical cancer, these findings may become diagnostic point of early oral cancer.


Assuntos
Neoplasias Gengivais/patologia , Neoplasias da Língua/patologia , Adulto , Capilares/patologia , Feminino , Neoplasias Gengivais/irrigação sanguínea , Humanos , Leucoplasia Oral/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias da Língua/irrigação sanguínea
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