RESUMO
Introduction: Oral health is a loyal part of general health. As per the World Health Organization (WHO), dental caries is the most widespread noncommunicable disease and is a significant universal public health concern. The main causative organism associated with this disease is Streptococcus mutans (S. mutans). Various synthetic agents like chlorhexidine and fluorides are commercially available to prevent dental caries. However, these have side effects. Presently, research is engaged in the use of plant extracts to develop an effective and biocompatible material that may be used safely in the oral cavity. Methodology: Four plants were collected-Emblica officinalis, Vitis vinifera seeds, Psidium guajava (P. guajava) Linn leaves, and Acacia nilotica (A. nilotica), and extracts were prepared individually. These extracts were subjected to phytochemical analysis, and bacterial growth and fermentation were assessed. Result: The level of significance was set at p < 0.05. All the plant extracts inhibited S. mutans growth at all serial dilutions except P. guajava Linn and A. nilotica showing 55 CFU/mL and 5 CFU/mL, respectively in 1/1000 dilution only. The phytochemical analysis confirmed that all four plant extracts had alkaloids, carbohydrates, tannins, and flavonoids. Steroids and proteins are present in P. guajava Linn. Proanthocyanidins were present in Vitis vinifera. Saponins and Anthraquinones were present in A. nilotica exclusively. Conclusion: All the extracts were effective against S. mutans. These could be tried as herbal alternatives to conventional adjuncts. However, these results must be additionally evaluated for toxicity in animal models, and effectiveness must be assessed using in vivo studies on human subjects. How to cite this article: Kripalani KB, Thomas NA, Thimmaiah C, et al. Comparative Evaluation of the Phytochemical Analysis and Efficacy of Four Plant-derived Extracts against Streptococcus mutans: An In Vitro Study. Int J Clin Pediatr Dent 2023;16(S-3):S258-S262.
RESUMO
BACKGROUND AND AIMS: Bone loss around dental implants is generally measured by monitoring changes in marginal bone level using radiographs. After the first year of implantation, an implant should have <0.2 mm annual loss of marginal bone level to satisfy the criteria of success. However, the success rate of dental implants depends on the amount of the crestal bone around the implants. The main aim of this study was to evaluate and compare the crestal bone loss around implants placed with particulate ß-Tricalcium Phosphate Bone Graft and platelet concentrates. METHODS: 50 individuals received hundred dental implants. Each individual received one dental implant in the edentulous site filled with ß-Tricalcium Phosphate Bone Graft along (ß-TCP) with Platelet- Rich Plasma (PRP) (Group A) and another in edentulous site filled only with ß-Tricalcium Phosphate Bone Graft (Group B) in the posterior edentulous region. All the 100 implants were prosthetically loaded after a healing period of three months. Crestal bone loss was measured on mesial, distal, buccal and lingual side of each implant using periapical radiographs 3 months, 6 months and 9 months after implant placement. RESULTS: The average crestal bone loss 9 months after the implants placement in Group A and Group B was 2.75 mm and 2.23 mm respectively, the value being statistically significant (P < 0.05). In both Group A and Group B, the average crestal bone loss was maximum on the lingual side followed by buccal, distal and mesial sides. CONCLUSION: ß-TCP is a promising biomaterial for clinical situations requiring bone augmentation. However, the addition of PRP results in decreased bone loss around the dental implants.
RESUMO
AIMS AND OBJECTIVES: Dental implants have emerged as new treatment modality for the majority of patients and are expected to play a significant role in oral rehabilitation in the future. The present study was conducted to assess various factors affecting the survival rate of dental implants. MATERIALS AND METHODS: The present retrospective study was conducted in the Department of Prosthodontics. In this study, 5200 patients with dental implants which were placed during June 2008-April 2015 were included. Exclusion criteria were patients with hormonal imbalance, patients with chronic infectious disease, patients receiving immunosuppressive therapy, pregnant women, drug and alcohol addicts, and patients with severe periodontal diseases. Parameters such as name, age, gender, length of implant, diameter of implant, location of implant, and bone quality were recorded. Data were tabulated and statistically evaluated with IBM SPSS Statistics for Windows, Version 20.0., IBM Corp., Armonk, NY, USA. RESULTS: Out of 5200 patients, 2800 were males and 2400 females. Maximum implants failures (55) were seen in age group above 60 years of age (males - 550, females -700). Age group <40 years (males - 750, females - 550) showed 20 failed implants. Age group 41-60 years (males - 1500, females - 1150) showed 45 failed implants. The difference was nonsignificant (P = 0.21). Maximum implant failure was seen in implants with length >11.5 mm (40/700) followed by implants with <10 mm (20/1650) and 10-11.5 mm (60/2850). The difference was significant (P < 0.05). Maximum implants failure (30/1000) was seen in implants with diameter <3.75 mm followed by implants with diameter >4.5 mm (16/1600) and implants with diameter 3.75-4.5 mm (50/2600). The Chi-square test showed significant results (P < 0.05). Mandibular posterior showed 3.3% implants failure, maxillary posterior revealed 2.2%, maxillary anterior showed 2.1%, and mandibular anterior showed 1% failure rate; this difference was significant (P < 0.05). Type I bone showed 0.3% implant failure, Type II showed 1.95%, Type III showed 3%, and Type IV revealed 0.8% failure rate; this difference was significant (P < 0.05). CONCLUSION: Age, length of implant, diameter of implant, bone quality, and region of implant are factors determining the survival rate of implants. We found that implant above 11.5 mm length, and with diameter <3.75 mm, placed in the mandibular posterior region, in Type III bone showed maximum failures.