[Effect of surgically induced bilateral cleft alveolar on maxillary growth in dogs].

OBJECTIVE: To establish an animal model of bilateral alveolar cleft and to determine the effect of cleft on maxillary growth. METHODS: Eight dogs (12 weeks old) were divided into unoperated control groups (n = 4) and the model group (n = 4). The model dogs were operated to establish a bilateral alveolar cleft. All the dogs were killed and the craniofacial morphology on clean skull was analyzed by the direct detection and CT. RESULTS: The length, the foreside width, and the foreside height of the maxillary in the model group were shrunken compared with those of the control group (P < 0.05). CONCLUSION: The alveolar cleft plays an important role in the maxillary aberration.

[Maxillofacial deformity caused by cancrum oris: a case report].

Cancrum oris is a kind of gangrenous disease happening on the maxillofacial region. It is characterized by developing rapidly, high lethality and deforming rate. This article reported a case of maxillofacial deformity caused by cancrum oris, and discussed based on relevant literatures.

[An investigation of restoration of alveolar cleft with engineered bone].

OBJECTIVE: To investigate restoration of alveolar cleft with engineered bone constructed by sponge collagen protein combined bone mesenchymal stem cells (BMSC). METHODS: Twelve dogs were divided into 4 groups, the third incisor and alveolar bone with periosteum in bilateral maxilla were removed to form alveolar cleft model. The BMSCs were isolated from dog bone marrow. After being cultured and induced, the BMSCs were seeded in sponge collagen protein and cultured for 48 hours. The composites of BMSCs and collagen were implanted into the defect of alveolar cleft. After 12 weeks' feeding, those dogs were sacrificed. Three-dimensional CT and histological examination were used to observe the progress of bone formation. RESULTS: The defects healed at 12 weeks after being implant BMSCs-collagen composites, the width of engineered bone is resembled with positive control, but the height is less than positive control. CONCLUSIONS: The engineered bone can restore the defect of alveolar bone effectively, it can be used clinically to treat alveolar cleft.