RESUMO
The typical antipsychotics chlorpromazine (CPZ) and trifluoperazine (TFP) increase the mean molecular area (mma) of acidic, but not neutral, glycerophospholipids in monolayers at pH 7.36 measured by the Langmuir technique. The atypical antipsychotic olanzapine (OLP(1)) is structurally similar to TFP. We have therefore studied the effects of OLP on glycerophospholipid monolayers and in comparison with CPZ. Olanzapine (10 microM, in subphase, pH 7.36) influenced the isotherms (surface pressure versus mma) in monolayers of the neutral dipalmitoyl phosphatidylcholine (DPPC) and the acidic dipalmitoyl phosphatidylserine (DPPS) or 1-palmitoyl-2-oleoylphosphatidylserine (POPS) in the increasing order of mma: DPPSAssuntos
Benzodiazepinas/farmacologia
, Glicerofosfolipídeos/química
, Membranas Artificiais
, Psicotrópicos/farmacologia
, 1,2-Dipalmitoilfosfatidilcolina/química
, Concentração de Íons de Hidrogênio
, Olanzapina
, Fosfatidilserinas/química
, Promazina/química
, Promazina/farmacologia
, Propriedades de Superfície/efeitos dos fármacos
, Temperatura