The effect of incorporating various reinforcement materials on flexural strength and impact strength of polymethylmethacrylate: A meta-analysis.

Polymethylmethacrylate (PMMA) is a widely used denture base material with a major drawback of inferior mechanical properties. In the existing published reports, most studies indicate the superiority of the incorporation of various reinforcement materials in PMMA in terms of the flexural strength (FS) and impact strength (IS), whereas none shows the compilation and comparison of all. The present meta-analysis aims at synthesizing all the available data. The purpose of this study was to systematically review the existing reports to compare and evaluate the effect of various reinforcement materials on FS and IS of heat-cured acrylic resin (PMMA) by combining the available evidence in a meta-analysis. A search strategy was adopted using PubMed, ScienceDirect, Ebscohost, Google Scholar, and Cochrane Central Register of Controlled Trials in February 2018 to screen research studies. These studies were screened against predetermined criteria for eligibility for meta-analysis. In the present meta-analysis, twenty articles were included. Out of 15 data available on reinforcement, 14 showed better results for IS of reinforced PMMA resin as compared to their respective control group. Out of the 25 available data, 11 showed better results for FS of reinforced PMMA resin when compared to their respective control group. The homogeneity test of meta-analysis confirmed acceptable heterogeneity among 15 reinforcement techniques of IS (i 2 = 95.8%) and 25 reinforcement techniques of FS (i 2 = 96.2%). A random-effects model and fixed-effects model were used for analysis. The present meta-analysis showed that reinforcement of PMMA can significantly increase FS and IS. Hence, it can be incorporated in clinical practice.

Preparation of functional and reactive nanosilver nanogels using oxidized carboxymethyl cellulose.

The designing of functional and reactive nanosilver has been carried out by in-situ reduction of silver nitrate using oxidized carboxymethyl cellulose (OCMC). The reduction process is also accompanied by the stabilization of nanoparticles using the OCMC polymer chain, leading to the formation of a structure where nanosilver is entrapped within OCMC gel. The silver nanogels characterized using transmission electron microscopy (TEM) are found to be ∼22 nm. By virtue of the presence of dialdehyde functionality around the silver nanogels, they have the ability to react with a polymer having a complementary functional group. The nanogels have exhibited prominent antimicrobial activity against both gram-negative and gram-positive bacteria. It has been observed that a 0.3 mM concentration of silver nanogel is active in inhibiting bacterial growth. The antibacterial activity of the synthesized Ag nanogels was dose-dependent, with 99.9 % of E. coli and S. aureus destroyed within 5 h at a concentration of 0.4 mM Ag nanogels. The nanogels disrupted the bacterial cell wall and generated reactive oxygen species inside the cell, which resulted in cell death. This investigation provides a very interesting application as a coating for biomedical implants and devices.

Bioactive Khadi Cotton Fabric by Functional Designing and Immobilization of Nanosilver Nanogels.

The antimicrobial finishing is the most suitable alternative for designing medical textiles for biomedical applications. The present investigation aims at the preparation of skin-contacting khadi cotton fabric that would prevent microbial infection and offer excellent skin compatibility. A simple approach has been followed for the preparation of bioactive nanogels for antimicrobial finishing of the khadi cotton fabric. Bioactive nanogels were synthesized by using aloe vera (AV) as a reducing agent for silver ions in the presence of polyvinyl alcohol (PVA). PVA stabilizes the growth of silver nanoparticles, which is influenced by the variation in the reaction time and the temperature. Nanogels were characterized by transmission electron microscopy and scanning electron microscopy analyses. The nanogels exhibited strong antimicrobial behavior against both Staphylococcus aureus and Escherichia coli, as confirmed by the colony count method. Almost 100% antibacterial behavior was observed for the nanosilver content of 10 mM. The nanogel-finished khadi fabric showed bactericidal properties against both S. aureus and E. coli. The nanogel-finished fabric exhibited high hydrophilicity allowing complete water droplet penetration within 10 s as compared to 136 s in virgin fabric. Moreover, the skin irritation study of the fabric on male Swiss albino mice did not show any appearance of dermal toxicity. These results demonstrated that the bioactive finished khadi fabric is appropriate as skin contacting material in human health care.