RESUMO
In this work, a label-free nonenzymatic photoelectrochemical (PEC) sensor is successfully developed for the detection of a typical pollutant, microcystin-LR (MC-LR), based on a visible-light-responsive alloy oxide, with highly ordered and vertically aligned Ti-Fe-O nanotubes (NTs) as substrates. Ti-Fe-O NTs consisting mainly of TiO2 and atomically doped Fe2O3 are in situ prepared on a Ti-Fe alloy by electrochemical anodic oxidation. Using a simple electrochemical deposition technique, reduced graphene oxide (RGO) could be grown onto Ti-Fe-O NTs, exhibiting significant bifunctions. It not only provides an ideal microenvironment for functionalization of molecularly imprinted polymers (MIPs) on the surface but also serves as the PEC signal amplification element because of its outstanding conductivity for photons and electrons. The designed MIP/RGO/Ti-Fe-O NT PEC sensor exhibits high sensitivity toward MC-LR with a limit of detection as low as 10 pM. High selectivity toward MC-LR is also proven for the sensor. A promising detection platform not only for MC-LR but also for other pollutants has therefore been provided.
Assuntos
Técnicas Eletroquímicas/métodos , Grafite/química , Toxinas Marinhas/análise , Microcistinas/análise , Polímeros Molecularmente Impressos/química , Poluentes Químicos da Água/análise , Técnicas Eletroquímicas/instrumentação , Eletrodos , Ferro/química , Limite de Detecção , Nanotubos/química , Processos Fotoquímicos , Reprodutibilidade dos Testes , Rios/química , Titânio/químicaRESUMO
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention). These facilely synthesized molecular nanoprobes showed great clinical translation potential as a versatile theranostic agent.