1.
Bioorg Med Chem Lett
; 17(24): 6841-6, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17980586
RESUMO
A series of 6-bicycloaryloxynicotinamides were identified as opioid receptor antagonists at mu, kappa, and delta receptors. Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors.