RESUMO
Chemically switched friction nano-fibrillar surfaces (SiNWAs-PSPMA & SiNWAs-PMAA arrays) can be constructed by finely decorating ordered Si nanowire arrays with responsive polymer brushes. As expected, these surfaces sense humidity or pH smartly and show reversible friction switching, based on swelling and shrinking of the polymer brushes, which is successfully monitored by AFM in liquid media.
Assuntos
Materiais Biomiméticos/química , Nanotecnologia/métodos , Adesividade , Animais , Eletrólitos , Fricção , Umidade , Concentração de Íons de Hidrogênio , Lagartos , Nanopartículas Metálicas/química , Microscopia de Força Atômica , Nanofibras/química , Nanofios , Polímeros/química , Silício/química , Propriedades de SuperfícieRESUMO
MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.
Assuntos
Antineoplásicos/administração & dosagem , Dissulfetos/química , Portadores de Fármacos/química , Molibdênio/química , Nanoestruturas/química , Fototerapia/métodos , Polietilenoglicóis/química , Animais , Antineoplásicos/farmacocinética , Camptotecina/administração & dosagem , Camptotecina/análogos & derivados , Camptotecina/farmacocinética , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Clorofilídeos , Terapia Combinada , Dissulfetos/efeitos adversos , Dissulfetos/síntese química , Doxorrubicina/administração & dosagem , Doxorrubicina/farmacocinética , Portadores de Fármacos/efeitos adversos , Feminino , Células HeLa , Humanos , Irinotecano , Células KB , Neoplasias Mamárias Experimentais/terapia , Camundongos , Camundongos Endogâmicos BALB C , Molibdênio/efeitos adversos , Nanoestruturas/efeitos adversos , Projetos Piloto , Polietilenoglicóis/efeitos adversos , Polietilenoglicóis/síntese química , Porfirinas/administração & dosagem , Porfirinas/farmacocinética , Radiossensibilizantes/administração & dosagem , Radiossensibilizantes/farmacocinéticaRESUMO
Organic electronics have gained widespread attention due to their flexibility, lightness, and low-cost potential. It is attractive due to the possibility of large-scale roll-to-roll processing. However, organic electronics require additional development before they can be made commercially available and fully integrated into everyday life. To achieve feasibility for commercial use, these devices must be biocompatible and flexible while maintaining high performance. In this study, biocompatible silk fibroin (SF) was integrated with a mesh of silver nanowires (AgNWs) to build up flexible organic solar cells with maximum power conversion efficiency of up to 6.62%. The AgNW/SF substrate exhibits a conductivity of â¼11.0 Ω/sq and transmittance of â¼80% in the visible light range. These substrates retained their conductivity, even after being bent and unbent 200 times; this surprising ability was attributed to its embedded structure and the properties of the specific SF materials used. To contrast, indium tin oxide on synthetic plastic substrate lost its conductivity after the much less rigid bending. These lightweight and silk-based organic solar cells pave the way for future biocompatible interfaces between wearable electronics and human skin.
Assuntos
Materiais Biocompatíveis/química , Fibroínas/química , Nanofios/química , Energia Solar , Eletrônica , Humanos , Seda/química , Prata/química , Compostos de Estanho/químicaRESUMO
Single- or few-layered transitional metal dichalcogenides, as a new genus of two-dimensional nanomaterials, have attracted tremendous attention in recent years, owing to their various intriguing properties. In this study, chemically exfoliated MoS2 nanosheets are modified with lipoic acid-terminated polyethylene glycol (LA-PEG), obtaining PEGylated MoS2 (MoS2-PEG) with high stability in physiological solutions and no obvious toxicity. Taking advantage of its ultra-high surface area, the obtained MoS2-PEG is able to load a photodynamic agent, chlorin e6 (Ce6), by physical adsorption. In vitro experiments reveal that Ce6 after being loaded on MoS2-PEG shows remarkably increased cellular uptake and thus significantly enhanced photodynamic therapeutic efficiency. Utilizing the strong, near-infrared (NIR) absorbance of the MoS2 nanosheets, we further demonstrate photothermally enhanced photodynamic therapy using Ce6-loaded MoS2-PEG for synergistic cancer killing, in both in vitro cellular and in vivo animal experiments. Our study presents a new type of multifunctional nanocarrier for the delivery of photodynamic therapy, which, if combined with photothermal therapy, appears to be an effective therapeutic approach for cancer treatment.
Assuntos
Dissulfetos/uso terapêutico , Nanopartículas Metálicas/uso terapêutico , Molibdênio/uso terapêutico , Nanocápsulas/química , Neoplasias Experimentais/terapia , Fotoquimioterapia/métodos , Polietilenoglicóis/química , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Clorofilídeos , Materiais Revestidos Biocompatíveis/síntese química , Terapia Combinada/métodos , Difusão , Dissulfetos/química , Humanos , Luz , Nanopartículas Metálicas/química , Molibdênio/química , Nanocápsulas/administração & dosagem , Nanocápsulas/ultraestrutura , Neoplasias Experimentais/patologia , Fármacos Fotossensibilizantes/administração & dosagem , Fármacos Fotossensibilizantes/química , Fototerapia/métodos , Porfirinas/administração & dosagem , Porfirinas/química , Resultado do TratamentoRESUMO
A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.