Secondary hypogonadism following hand, foot, and mouth disease in an adult: a case report and review of literature.

BACKGROUND: Previous reports have described hypogonadism associated with virus infection such as hantavirus, human immunodeficiency virus (HIV) or severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). However, to our best knowledge there has been no case report of secondary hypogonadism following hand, foot, and mouth disease (HFMD). CASE PRESENTATION: A previously healthy 28-year-old man with no history of major physical and psychological trauma, presented with bilateral gynecomastia and erectile dysfunction 2 weeks after HFMD. Laboratory testament showed the level of gonadotropin hormones declined. Imaging examination demonstrated no major abnormal change in pituitary or reproductive system. The diagnosis of hypogonadism was established. Then the patient was ordered to maintain mental health outward of hospital without drug intervention. One month after presentation, his gonadotropin hormone level and sexual desire had recovered, while bilateral gynecomastia and erectile dysfunction symptoms disappeared. CONCLUSIONS: Physicians should notice the possibility for hypogonadism in adult patients with a recent history of HFMD.

[First derivative spetrophotometric direct determination of 2-hydroxy-4-methoxybenzo phenone in polyester resin by computer assistant].

2-hydroxy-4-methoxybenzo phenone (UV-9) is one of general auxiliary reagents used in paint resin and plastics, which can delay the material degradation and ageing of high polymer. Direct determination of high polymer by ultraviolet spectrum has not been reported. We selected an efficient solvent that can dissolve the resin of high polymer, and got an even, transparent and steady mensuration system. The first derivative absorption data of 2-hydroxy-4-methoxybenzo phenone (UV-9) were treated many times with smooth handing by Origin 6.1, a famous data analysis software. At a certain wavelength, the results accord with Beer's law from 1.000 to 20.00 microg x mL(-1), thus UV-9 can be measured directly. Its absorptivity is 5.7 x 10(4) L x mol(-1) x cm(-1). The results of synthetic samples determined by this method showed that the relative standard deviation and the relative error of UV-9 are less than 5.25% and 4.75% respectively, and the UV-9 recovery rate is 98.88%-102.04%.