Multi-Stimuli-Responsive and Cell Membrane Camouflaged Aggregation-Induced Emission Nanogels for Precise Chemo-photothermal Synergistic Therapy of Tumors.

Targeted and controllable drug release at lesion sites with the aid of visual navigation in real-time is of great significance for precise theranostics of cancers. Benefiting from the marvelous features (e.g., bright emission and phototheranostic effects in aggregates) of aggregation-induced emission (AIE) materials, constructing AIE-based multifunctional nanocarriers that act as all-arounders to integrate multimodalities for precise theranostics is highly desirable. Here, an intelligent nanoplatform (P-TN-Dox@CM) with homologous targeting, controllable drug release, and in vivo dual-modal imaging for precise chemo-photothermal synergistic therapy is proposed. AIE photothermic agent (TN) and anticancer drug (Dox) are encapsulated in thermo-/pH-responsive nanogels (PNA), and the tumor cell membranes are camouflaged onto the surface of nanogels. Active targeting can be realized through homologous effects derived from source tumor cell membranes, which advantageously elevates the specific drug delivery to tumor sites. After being engulfed into tumor cells, the nanogels exhibit a burst drug release at low pH. The near-infrared (NIR) photoinduced local hyperthermia can activate severe cytotoxicity and further accelerate drug release, thus generating enhanced synergistic chemo-photothermal therapy to thoroughly eradicate tumors. Moreover, P-TN-Dox@CM nanogels could achieve NIR-fluorescence/photothermal dual-modal imaging to monitor the dynamic distribution of therapeutics in real-time. This work highlights the great potential of smart P-TN-Dox@CM nanogels as a versatile nanoplatform to integrate multimodalities for precise chemo-photothermal synergistic therapy in combating cancers.

[Influence of mandibulotomy approaches on oral function following radical resection of tongue carcinoma].

OBJECTIVE: This study aimed to compare the influences of postoperative oral function in patients with median or paramedian mandibulotomy during the radical resection of tongue carcinoma and to provide evidence for the choice of osteotomy location for mandibulotomy. METHODS: The clinical data of 126 patients who underwent combined radical neck dissection with mandibulectomy and glossectomy followed by simultaneous reconstruction were analyzed retrospectively. The patients were divided into two groups according to the position of mandibulotomy: median mandibulotomy group (median group, n=60) and paramedian mandibulotomy group (paramedian group, n=66). The fourth edition of the University of Washington Quality of Life Questionnaire (UW-QOL) was used to compare the differences in oral functions, such as swallowing, mastication, and speech, between the two groups during regular follow-up. SPSS 24.0 software package was used for statistical analysis, and P<0.05 was considered statistically significant. RESULTS: Six months after the operation, no significant differences in swallowing, mastication, and speech functions were found between the median and paramedian groups. However, the swallowing and speech functions in the paramedian group were better than those in the median group 1 year after the operation (P<0.05), whereas no statistical difference in mastication function was observed between the two groups. CONCLUSIONS: Evaluation of the postoperative oral function results showed that paramedian mandibulotomy was a better surgical approach than median mandibulotomy. Paramedian mandibulotomy is worth prioritizing in the radical resection of tongue carcinoma.

[Photosynthetic capacity and water use efficiency of tropical montane rainforest seedlings or saplings in Hainan Island].

By using a Li-6400 portable photosynthesis system, this paper measured the maximal photosynthetic capacity (P(max)) and water use efficiency (WUE) of the seedlings or saplings of 150 species of tropical montane rainforest in Hainan Island. The results showed that among the test 150 species, Quercus bambusifolia (Fagaceae) had the highest P(max) (13.27 micromol x m(-2) x s(-1)) and Macaranga denticulate (Euphorbiaceae) had the highest WUE (5.99 mmol x mol(-1)), while Decaspermum cambodianum (Myrtaceae) had the lowest P(max) (1.35 micromol x m(-2) x s(-1)) and Sapium discolor (Euphorbiaceae) had the lowest WUE (2.4 mmol x mol(-1)). The average P(max) was the highest in Moraceae but the lowest in Myrtaceae, and the average WUE was the highest in Symplocaceae but the lowest in Moraceae. However, there were no significant differences (P > 0.05) among the families. No significant differences (P > 0.05) in P(max) and WUE were also observed among arbors and shrubs. The P(max) value increased significantly (P < 0.05) with the widening of families' geographical distribution range, in the order of narrow distribution families < medium distribution families < wide distribution families, while no significant differences were existed among their WUE (P > 0.05). The P(max) value also increased with the widening of species' geographical distribution range, in the order of endemic species in Hainan Island < tropical species < tropical-subtropical species < tropical-subtropical-temperate species, but WUE was opposite to P(max), namely, in the order of endemic species in Hainan Island > tropical-subtropical species > tropical species > tropical-subtropical-temperate species.