RESUMO
Stroke is one of the most serious problems that seriously affect people's health and brings huge economic burden to society. The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In recent years, nano drug delivery system has developed rapidly and applied to treat ischemic stroke. Here, we report the synthesis and functionalization of monodisperse hollow structured MnO2 (H-MnO2). The highly monodisperse H-MnO2 with uniform morphology was obtained by in situ growing MnO2 on solid silica nanoparticles and subsequently removing the silica core. After successive modification of poly ethylene glycol(PEG), we further verified their protective effect on ischemic stroke in our study.
Assuntos
Infarto da Artéria Cerebral Média/tratamento farmacológico , Compostos de Manganês/química , Sistemas de Liberação de Fármacos por Nanopartículas/química , Óxidos/química , Polietilenoglicóis/química , Dióxido de Silício/química , Animais , Apoptose/efeitos dos fármacos , Comportamento Animal , Modelos Animais de Doenças , Liberação Controlada de Fármacos , Humanos , Masculino , Teste do Labirinto Aquático de Morris , Sistemas de Liberação de Fármacos por Nanopartículas/administração & dosagem , Sistemas de Liberação de Fármacos por Nanopartículas/efeitos adversos , Ratos , Ratos Sprague-Dawley , Propriedades de SuperfícieRESUMO
Primary bone lymphoma (PBL) is a rare primary extranodal lymphoma. It can occur in many parts of the body but rarely in the maxilla. We describe a case of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging revealed solitary osseous lytic lesion with intense uptake in the maxilla, suggesting a primary skeletal malignancy. The subsequent histopathologic examination confirmed the diagnosis of high-grade B-cell lymphoma (HGBL).
Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Fluordesoxiglucose F18 , Linfoma/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Neoplasias Ósseas/patologia , Feminino , Humanos , Linfoma/patologia , Maxila , Pessoa de Meia-IdadeRESUMO
High excimer-state emission in the H-type aggregate of a novel asymmetric perylene bisimide derivative, 6, with triethyleneglycol chains and lactose functionalization was achieved in water. Furthermore, its application for enhancing the visualization of transfer latent fingerprints from glass slides to the poly(vinylidene fluoride) (PVDF) membrane was explored, which showed clear images of the latent fingerprint in daylight and under 365â nm ultraviolet illumination.
Assuntos
Dermatoglifia , Imidas/química , Perileno/análogos & derivados , Fluorescência , Vidro/química , Humanos , Perileno/química , Polivinil/químicaRESUMO
A novel water-soluble fluorescent glycodendrimer based on perylene bisimides is synthesized, which exhibits high fluorescence quantum yield of 54%. While the binding interactions of PBI-Man with Concanavalin A (Con A) are studied by fluorescence spectra and CD spectra, which show strong binding affinity for Con A with the binding constant of 3.8 × 10(7) m(-1) for monomeric mannose, nearly four orders of magnitude higher affinity than the monovalent mannose ligand. Furthermore, the fluorescence imaging of macrophage cell with PBI-Man is investigated, and shows selectively binding interaction with the mannose receptor-medicated cell entry. Moreover, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) activities of PBI-Man show that PBI-Man as a biocompatible agent is noncytotoxic to living cells.
Assuntos
Materiais Biocompatíveis/síntese química , Técnicas Biossensoriais , Concanavalina A/química , Dendrímeros/síntese química , Fluorescência , Imidas/síntese química , Imagem Molecular , Perileno/análogos & derivados , Animais , Materiais Biocompatíveis/química , Sobrevivência Celular , Dicroísmo Circular , Dendrímeros/química , Imidas/química , Macrófagos/citologia , Camundongos , Conformação Molecular , Estrutura Molecular , Perileno/síntese química , Perileno/química , Espectrometria de FluorescênciaRESUMO
Transarterial radioembolization with radionuclide-labeled microspheres is successfully used in hepatocellular carcinoma (HCC) treatment, but the non-biodegradability and rapid settlement of the microsphere material are associated with unsatisfied distribution and unable for multiple administrations. In this study, a novel biodegradable chitosan-collagen composite microsphere (CCM) with ideal settlement rate is prepared. The Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) results indicate CCMs have desirable shapes with diameters around 10 µm, and considerable biodegradability within 12 weeks. These CCMs are successfully radiolabeled with 131 I and processed efficiency of 70.4 MBq mg-1 of microspheres as well as favorable stability in vitro. Then, 131 I-CCMs are injected into rats with orthotopic HCC via the hepatic artery which effectively improves the median overall survival from 19 to 44 days (p < 0.05). Single photon emission computed tomography (SPECT/CT) imaging and immunohistochemical analysis indicate well-localized biodistribution and consistent stability of 131 I-CCMs in the liver over 28 days. Magnetic resonance imaging (MRI) and gross specimens monitoring confirm the inhibited tumor growth after 131 I-CCMs treatment. In conclusion, these biodegradable 131 I-CCMs exhibit optimal radiolabeling efficiency, stability, and favorably radioembolization effect for orthotopic HCC in a rodent model, suggesting potential for interventional cancer therapy.