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J Chromatogr Sci ; 61(2): 195-202, 2023 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-35543326

RESUMO

A new molecularly imprinted polymers (MIPs) have been prepared for the high selective extraction of lamotrigine (LTG), a widely used antiepileptic drug, in human serum. The MIPs were polymerized by bulk polymerization using our synthesized compound, 2-(4-vinylphenyl) quinolin-4-carboxylic acid, as functional monomer, which achieved better adsorption specificity than universal MIPs. Then, the molecularly imprinted solid phase extraction (MISPE) based on this material was coupled with high-performance liquid chromatography (HPLC) for the detection of LTG in human serum. The results of method validation showed that the developed method presented a good precision and accuracy, and the linearity was in the range of 1.50-40.00 mg/mL with the limit of quantitation (LOQ) at 0.20 mg/mL. The recovery ranged from 80.8% to 83.8% with RSD ranges from 5.5% to 11.1%. The validated method was successfully used to determine the concentration of LTG in human simulate serum samples.


Assuntos
Impressão Molecular , Polímeros Molecularmente Impressos , Humanos , Lamotrigina , Anticonvulsivantes , Impressão Molecular/métodos , Polímeros/química , Extração em Fase Sólida/métodos , Cromatografia Líquida de Alta Pressão/métodos , Adsorção
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