RESUMO
Aim: To realize the transit and release of cancer drug exactly as well as high drug loading ratio, we reported a biocompatible and temperature responsive controlled drug delivery system based on 3D mesoporous structured Au networks. Materials & methods: Here, we filled the hollow interiors of Au networks with a phase-change material so that the drug release was easily regulated by controlling the temperature only. Results: Thanks to the high near-infrared reflectance absorbance and mesoporous structure, the Au-PEG + lauric acid/doxorubicin system showed a strong photothermal conversion efficiency, high drug-loading ratio (54.2% for doxorubicin) and controlled drug release. Conclusion: This system revealed great advantages in photothermal therapy and chemotherapy, offering an obvious synergistic effect in cancer treatment.
Assuntos
Antineoplásicos/química , Doxorrubicina/química , Portadores de Fármacos/química , Ouro/química , Nanopartículas Metálicas/química , Animais , Antineoplásicos/farmacologia , Linhagem Celular Tumoral , Terapia Combinada/métodos , Doxorrubicina/farmacologia , Liberação Controlada de Fármacos , Hipertermia Induzida , Ácidos Láuricos/química , Luz , Camundongos , Processos Fotoquímicos , Fototerapia/métodos , Polietilenoglicóis/química , Porosidade , Propriedades de SuperfícieRESUMO
A hierarchical nanoparticle strategy to simultaneously gain super Raman signal amplification, high uniformity, and reproducibility is presented. Using hollow Au-Ag alloy nanourchins, an ultrahigh sensitivity, e.g., down to 1 fM concentrations for DEHP molecule is obtained. A small standard deviation of <10% is achieved by simply dropping and evaporating sub-100 nm nanourchins onto a substrate.